Sentences with phrase «observing entorhinal»
«By observing entorhinal - hippocampal neurons based on their birthdate, we realized that these cells were somehow special and very different from the other surrounding cell types, which was instrumental to find out how and to what extent they influenced the assembly of the network.»
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Precise positional modulation was not observed more ventromedially in the entorhinal cortex or upstream in the postrhinal cortex, suggesting that sensory input is transformed into durable allocentric spatial representations internally in the dorsocaudal medial entorhinal cortex.
«In the case of Alzheimer's disease, one of the first cell types affected by the pathology is one that we've observed to play a leading role in the development of the entorhinal - hippocampal network.»
«Immediately after the rat is exposed to the smell there is a burst in activity of 20 Hz waves in a specific connection between an area in the entorhinal cortex, lateral entorhinal cortex (LEC), and an area in the hippocampus, distal CA1 (dCA1), while a similar strong response was not observed in other connections,» Igarashi explains.
In the six subjects, we observed significantly shorter latency (Figure 2A) and shorter excess path length for locations that had been learned during stimulation of the entorhinal region in blocks 1, 2, and 3, than for locations that had been learned without stimulation (latency, z = − 2.20, P = 0.03; excess path length, z = − 2.20, P = 0.03; effect size, [Cohen's] d = 1.74)(Figure 2A and 2C, respectively).
The theta rhythm (3 to 8 Hz) is a large EEG potential recorded from the hippocampus in rodents and humans29, 37 and is thought to aid formation of memories.37 It has been suggested that resetting of the phase of the theta rhythm improves memory performance by allowing the best possible encoding of novel stimuli.38 Stimulation of the perforant pathway in rodents induces resetting of the theta phase and produces favorable conditions for long - term potentiation.9, 39 In four subjects in our study who had contacts implanted in the entorhinal region and ipsilateral hippocampus, we observed theta - phase resetting in the hippocampus during stimulation of the entorhinal region.