As it turns out,
the octopus genome is almost as large as a human's and actually contains more protein - coding genes: 33,000, compared with fewer than 25,000 in humans.
Instead, the evolution of
the octopus genome was likely driven by the expansion of a few specific gene families, widespread genome shuffling and the appearance of novel genes.
The octopus genome contains 168 protocadherin genes — 10 times more than other invertebrates and more than twice as many as mammals.
The octopus genome contains around 1,800 C2H2 zinc finger transcription factors, the second largest gene family so far discovered in animals (olfactory receptor genes in elephants are the largest at around 2,000).
The octopus genome is enriched in transposons, also known as «jumping genes,» which can rearrange themselves on the genome.
The large size of
the octopus genome was initially attributed to whole genome duplication events during evolution, which can lead to increased genomic diversity and complexity.
They identified more than 33,000 protein - coding genes, placing
the octopus genome at slightly smaller in size, but with more genes, than a human genome.
The octopus genome contains 168 of these special genes, known as protocadherins, twice the amount found in most mammals.
While
the octopus genome resembles those of other marine invertebrates in many respects, it also revealed unexpected features that are key to understanding the origin and function of its unique nervous system.
The octopus genome, however, shows no evidence of such a dramatic event in its evolutionary history.
Prof. Brenner was fascinated with the great sophistication of their nervous system and initiated
the octopus Genome Project as the first of several important genome projects that have become a hallmark of OIST.
Genes that are grouped together on chromosomes in other animals were dispersed in
the octopus genome, likely as a result of transposon activity.
«
The octopus genome makes studies of cephalopod traits much more tractable, and now represents an important point on the tree of life for comparative evolutionary studies,» said Ragsdale, an associate professor in neurobiology and organismal biology and anatomy at the University of Chicago.
The sequencing of
the octopus genome, published in August, offers a surprising answer.
To preserve their RNA - editing powers,
octopus genomes are much more resistant to mutation, the driving force of natural selection.
Not exact matches
The
genome shows that
octopuses have the same small repertoire of neurotransmission genes as lower mollusks.
An international team of scientists has sequenced the
genome of an
octopus, bringing researchers closer to discovering the genes involved in the creature's unusual biology, including its ability to change skin color and texture and a distributed brain that allows its eight arms to move independently.
The researchers also used the
genome to track down the genes involved in adaptive coloration, which allows the
octopus to change its skin color and texture in order to blend into its environment and escape predation.
The
genome could also help uncover the genetic basis for other
octopus innovations, such as their elaborate prehensile arms with suckers used to sense chemicals in the water as well as feel and grasp; their ability to regenerate their limbs; a propulsion system that allows them to jet around underwater; camera - like eyes that are more like humans than other invertebrates; and the fact that they have three hearts to keep blood pumping across their gills.
As many mysteries as the
octopus holds — its comprehensive camouflage, smart suckers, agile brain — its
genome is surely holding many more (including how it can regenerate its arms — suckers, nerves and all).
A team of researchers from the Okinawa Institute of Science and Technology Graduate University (OIST), the University of Chicago, and the University of California, Berkeley have sequenced and analyzed the
genome of an
octopus species, making it the first cephalopod to be decoded.
The results yield a couple of interesting surprises: For starters, Albertin and her colleagues found that the relatively massive
genome of the
octopus (2.7 billion base - pairs for this particular species, compared to around 3 billion in humans) wasn't due to duplication, as some researchers have suggested.
«The
octopus has a large and complex
genome, so this was no trivial task,» study author Caroline Albertin, a graduate student at the University of Chicago, told The Post.
Researchers have produced the first complete
genome sequence for any
octopus, laying out all of the genes that make the species
Octopus bimaculoides what it is.
With no tell - tale signs of whole
genome duplication, the researchers say, the
octopus must have instead duplicated specific regions of its genetic code — and acquired totally novel genes — over the course of its evolution.
The
octopus also appears to have a large number of transposons, or «jumping genes» that are capable of rearranging their position in the
genome.
Scientists stitched together the complex
genome of the California two - spot
octopus, and analyzed 12 different tissues in search of the genes that allow these unique cephalopods to change skin color and control eight arms independently.
«The
octopus basically has a normal invertebrate
genome that's just been completely rearranged, like it's been put into a blender and mixed,» said Caroline Albertin, a graduate student at the University of Chicago and coauthor on the study, in a prepared statement.
To study the genetics of these specialized traits, Ragsdale and his colleagues sequenced the
genome of the California two - spot
octopus (
Octopus bimaculoides) to a high level of coverage (on average, each base pair was sequenced 60 times).
An international team of scientists sequenced the
genome of the California two - spot
octopus — the first cephalopod ever to be fully sequenced — and mapped gene expression profiles in 12 different tissues.
The first whole
genome analysis of an
octopus reveals unique genomic features that likely played a role in the evolution of traits such as large complex nervous systems and adaptive camouflage.
«With a few notable exceptions, the
octopus basically has a normal invertebrate
genome that's just been completely rearranged, like it's been put into a blender and mixed,» said Caroline Albertin, co-lead author and graduate student in the Department of Organismal Biology and Anatomy at the University of Chicago.
Scientists have now analyzed the DNA sequence of the California two - spot
octopus (
Octopus bimaculoides) and found an unusually large
genome.
«It's important for us to know the
genome, because it gives us insights into how the sophisticated cognitive skills of
octopuses evolved,» says neurobiologist Benny Hochner who has studied
octopus neurophysiology for 20 years.