To evaluate
the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil.
Objective To evaluate
the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil.
Structural eye anomalies (in particular, microphthalmia and coloboma), cataracts, intraocular calcifications, and posterior
ocular findings have been reported in infants with presumed and laboratory - confirmed prenatal ZIKV infection; however, posterior findings have been the most prevalent.21,25,28,33,35,36,41 - 43 Case series report chorioretinal atrophy, focal pigmentary mottling of the retina, and optic nerve atrophy / anomalies.28, 34,37,41 - 43,55 Series of 20 or more infants with presumed ZIKV - associated microcephaly report
ocular findings in 24 % to 55 %.28, 33,42 In one study, testing for ZIKV IgM was performed in 24 of 40 infants (60 %) with microcephaly and the results were positive in the cerebrospinal fluid in 100 % of those tested.42 The proportion of infants with ocular lesions did not differ in those with and without testing.42 In that series, first trimester maternal infection and smaller head circumference significantly correlated with the presence of abnormal
ocular findings.42
Active chorioretinitis, a possible precursor of chorioretinal atrophy, has not been reported in infants with congenital ZIKV infection, and the pattern of
ocular findings differs from those in other congenital infections.56 In particular, retinal lesions, including well - defined chorioretinal atrophy and gross pigmentation, generally affecting the macular region, are unique to ZIKV infection (Figure 3).
One reason for their inclusion is that many also have mutations with
ocular findings only.
In addition, it is unknown how often infants born without recognizable abnormalities of ZIKV infection will later develop problems (e.g., cognitive impairment, hearing loss,
ocular findings), as has been seen with other congenital infections, for example, rubella.»
As most studies have only carefully examined infants with presumed or confirmed congenital ZIKV infection who have microcephaly, more studies are needed to understand
ocular findings in those infants with congenital ZIKV infection without microcephaly.
Not exact matches
UNITY BluTech lenses contain two natural blue - filtering properties that are
found in the human eye:
Ocular Lens Pigment and Melanin.
Researchers say the
finding could be harnessed in the future to make an «eye in a dish,» a tool that would be invaluable in coaxing stem cells to develop into
ocular tissues.
They detected little or no MHCI expression in some areas of the brain, but they
found it in several other places, including the visual cortex while the
ocular dominance columns were forming, and in the hippocampus — an area of the brain associated with learning and memory — at all ages.
«The concept of columns in the brain is not entirely new,» observes Hosoya, referring to orientation and
ocular dominance columns
found in the visual cortices of monkeys and cats.
Researchers who observed great white sharks scavenge a whale carcass off the coast of South Africa
found that multiple animals fed beside each other at the same time, displaying relaxed behavior such as a belly - up posture and a lack of
ocular rotation.
Looking at 250 samples in the lab (116 from cotton swabs of the conjunctiva, 114 from cotton swabs of skin under the eye, and 20 contact lenses), researchers
found a higher diversity of bacteria on the
ocular surface than on the skin under the eye or on the contact lenses, which was a surprising result, Dominguez - Bello said.
Additionally the presence of an accessory tear gland allows for even greater tear production and rinsing of the
ocular surface than is
found in primates.
«New
findings show promise for treatment of Graves» disease and other
ocular disorders.»
Researchers
found that survivors were at significantly increased risk of
ocular deficits, blurred vision, hearing loss, and neurologic abnormalities such as difficulty swallowing and sleeping.
The
finding, reported in tomorrow's issue of Science, gives insight into potential treatments for people with
ocular herpes, the principal infectious cause of blindness in developed countries.
The team
found that, unlike control mice, which only undergo
ocular dominance shifts if an eye is closed early in life, mice without Lynx1 still showed these shifts for eye manipulations well into adulthood.
The authors speculate that possible explanations for this
finding is that reflex tearing might help flush PM from the
ocular surface, or that environmental PM10 levels currently in Korea are not high enough to induce adverse effects on the
ocular surface.
In 459 patients with
ocular melanoma at 12 centers in the United States and Canada, the researchers
found the test could successfully classify tumors more than 97 percent of the time.
Each parasite egg and larvae
found was photographed and measured at 40 × and 60 × with a calibrated
ocular micrometer.
These
findings indicate that FHV - 1 causes qualitative tear film abnormalities that may contribute to
ocular discomfort, prolonged healing of ulcers, and persistent inflammation.
Rockstar was also
found to have bladder stones and an
ocular condition called entropion where the eyelid margins roll inward causing irritation to his corneas.
The Canine Eye Registration Foundation regularly evaluates the
ocular diseases commonly
found in each breed.
As certain
ocular problems are
found to be more frequent or believed to have an inherited component to them, it may be advised that affected animals should not be bred.
During a two year period in the early 1980s, 144 Cavaliers were screened for eye problems in Sweden, and 11 cases of congenital
ocular defects were
found.
Currently, her lab is focused on
finding drugs suitable for eliminating mammary cancer and
ocular herpevirus infections in small companion animals, and evaluating the effectiveness of stem cell therapies for treating skin wounds in horses — all of which may also be used in humans and other animals.