Not exact matches
Ophthalmologists at 10 sites nationwide tested the ring
in a phase 2 clinical trial on patients with glaucoma or
ocular hypertension.
«Because PGAs are a first line of treatment for glaucoma, these results provide physicians with one reason to reconsider when they should be added
in new patients, particularly those where the aim is to prevent glaucoma such as
in ocular hypertension patients or glaucoma suspects,» Dr. Pasquale said.
During this time, I have been actively engaged
in clinical studies of participants that have been diagnosed with glaucoma or high - risk
ocular hypertension, as well as
in laboratory - based studies on experimental glaucoma models
in rodents and non-human primates.
The published paper concluded that» «molecular alterations detected
in the
ocular hypertensive human retina as opposed to previously detected alterations
in human donor retinas with clinically manifest glaucoma suggest that proteome alterations determine the individual threshold to tolerate the
ocular hypertension - induced tissue stress or convert to glaucomatous neurodegeneration when intrinsic adaptive / protective responses are overwhelmed.»
The idea that mucins might be present
in this lining layer and play a role
in ocular hypertension has not been previously considered.
Ocular hypertension is a condition
in which the measured eye pressure is consistently greater than «normal.»
Summary: All forms of glaucoma have
in common optic nerve degeneration characterized by typical visual field defects, and are usually associated with elevated intraocular pressure, also known as
ocular hypertension (OH).
Retinal ganglion cell loss
in a rat
ocular hypertension model is sectorial and involves early optic nerve axon loss.
Blood pressure should also be carefully assessed
in any cat with chronic kidney disease, hyperthyroidism, heart disease,
in cats with sudden onset blindness, or
in cats with other
ocular or neurological signs that might suggest underlying
hypertension.
In the absence of blood pressure measurement devices, a thorough
ocular (eye) examination may enable a diagnosis of
hypertension to be made and can be used to monitor progress once treatment has been started.
The most common postoperative complications
in this study were: postoperative
ocular hypertension 22.9 %; corneal lipid opacity 19.0 %, uveitis 16.2 %, intraocular hemorrhage 12.3 % (intraocular hemorrhage, a common cause of an undesirable outcome, was 494.5 times more likely
in Boston terriers and 174.4 times more likely
in Poodles), retinal detachment 8.4 % (more common
in Boston terriers, poodles, the Bichon Frise, and Shih Tzu) and glaucoma 6.7 %.
The incidence of postoperative
ocular hypertension (POH), postoperative glaucoma and blindness have recently been reported to be significantly higher
in Labrador Retrievers (probabilities of postoperative blindness
in Labradors were 5 %, 9 %, 15 % and 27 % at weeks 4, 26, 52 and 104, respectively) versus non-Labradors (ref.
Cats with advanced secondary
hypertension will typically exhibit problems associated with the systems that are affected by the condition: the
ocular system (sudden blindness or retinal hemorrhaging); the renal system (poor appetite, weight loss, increased drinking and urination); the neurologic system (seizures, disorientation); and the cardiovascular system (difficulty
in breathing).
- Low body temperature - Poor body condition, showing weight loss - Excessive skin tenting and dry gums showing dehydration - Unkempt hair coat - Sharp or bad breath, possibly with ulcers
in the mouth - Pale gums - Evidence of
ocular hemorrhage or blindness associated with high blood pressure (
hypertension)
(b)
In Alcon Canada Inc. v. Apotex Inc. 2014 FC 699 Justice Kane again focussed on Alcon's patent claims which referred only to «Use of a therapeutically effective amount of a compound... for the treatment of glaucoma and
ocular hypertension.»