Signs that can be indicative
of ocular irritation include redness of the eyes, squinting, ocular discharge / tearing, and / or rubbing at the eyes.
Entropion is a conformational defect resulting in «in - rolling» of one or more of the eyelids, which
causes ocular irritation.
Formulated without parabens, phthalates, petrochemicals, bismuth, talc, synthetic fragrances, or synthetic dyes, this advanced formula has been clinically tested
for ocular irritation.
Thus, the study by Berdoulay et al concluded that topical tacrolimus may represent an alternative treatment for canine KCS patients receiving CsA when irritation prevents the use of CsA (the primary side effect of topical CsA administration is
ocular irritation) or when there is an inadequate response to CsA.
Adverse reactions of
ocular irritation and corneal ulceration have been reported in association with such use.