Background: Olfactory receptors (ORs) recognize
odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell.
For example, based on the perception of the hundreds of
odorant molecules found in coffee, the piriform cortex would be able to recognize a single odor, that of coffee.
Before it tunnels, the electron distorts
the odorant molecule's electrical field.
Not exact matches
Turin says the strongest tests of his theory so far come from studies in which researchers replace an
odorant atom with an isotope of that atom, which has a slightly different weight and changes the
molecule's frequency of vibration.
Turin's more controversial theory, put forth in 1996 and now the subject of two popular books, holds instead that
odorant receptors sense the way a
molecule's atoms jiggle.
Zwiebel and colleagues scanned the mosquito genome looking for genes similar to those that generate fruit fly
odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain
molecules in the air.
The
odorant receptor
molecules sit on the surface of sensory nerve cells in our nose.
Most scents are composed of many
odorants; a whiff of chocolate, for example, is made up of hundreds of different odor
molecules.
Then, as now, the prevailing notion was that the sensation of different smells is triggered when
molecules called
odorants fit into receptors in our nostrils like three - dimensional puzzle pieces snapping into place.
C. elegans has the ability to distinguish between hundreds of different odors due to a range of
molecules —
odorant receptors — on the surface of a cluster of neurons at the tip of its head.
In principle,
odorant isotopomers provide a possible test of shape vs. vibration mechanisms: replacing, for example, hydrogen with deuterium in an
odorant leaves the ground - state conformation of the
molecule unaltered while doubling atomic mass and so altering the frequency of all its vibrational modes to a greater or lesser extent [11].