Sentences with phrase «oestrogen receptor»

The phrase "oestrogen receptor" refers to a special protein in our body that can bind with the hormone oestrogen. It acts like a lock and key, allowing oestrogen to influence certain functions in our cells and organs. Overall, the oestrogen receptor helps regulate various processes and functions in the body that are affected by oestrogen. Full definition
«The study shows that long - term use of Tamoxifen does not increase incidence of breast cancer in the opposite breast, but it may increase the proportion of oestrogen receptor negative cancers.
«A better understanding of the biological basis of oestrogen receptor negative breast cancer may lead to more effective preventive interventions and treatments.»
The compound, which is widely prescribed for breast cancer, is known to block oestrogen receptors on many cancer cells, so inhibiting their growth.
His lab hopes to knock out a specific oestrogen receptor in dogs to understand the hormone's effects on fertility.
Because her tumour cells had tested positive for oestrogen receptors, she was also put on tamoxifen, a drug that blocks the supply of the female sex hormone that triggers some breast tumours to grow.
The data included information on the age of diagnosis, region of residence, deprivation, ethnicity, tumour size, grade, oestrogen receptor status (ER), Herceptin receptor status (HER2), and whether or not the cancer had spread to the lymph nodes.
It doesn't just bind to the main oestrogen receptor, but also to poorly understood variants of it, and has an anti-androgen effect.
One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.
«When we treat people with this inhibitor we want to know if we block metastases, and if we increase the response to anti-oestrogen because we induced the expression of oestrogen receptors,» Normand says.
The studies identified genetic regions specifically associated with either oestrogen - receptor positive or oestrogen receptor negative breast cancer, underscoring the fact that these are biologically distinct cancers that develop differently.
Breast Cancer Care comment on claims that long - term use of Tamoxifen may increase proportion of oestrogen receptor (ER) negative cancers which develop in the opposite breast
Comment on research published in Cancer Research which claims that long - term use of Tamoxifen may increase the proportion of oestrogen receptor (ER) negative cancers which develop in the opposite breast.
By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.
Because of a quirk of evolution, these plant chemicals are close enough to the natural hormone's shape to bind to the oestrogen receptors on cells in the human body.
«This means that tamoxifen, which is probably the best therapy for breast cancer available, is not working solely through blocking the oestrogen receptors, which everyone thought it did.
Anthony Colletta, leader of the team, says studies had shown that women benefited from taking tamoxifen even if their breast cancer cells had no oestrogen receptors.
«We used different groups of mice, in which either the oestrogen receptor or RANKL was inactivated in hematopoietic cells or in mesenchymal cells, to be able to identify the target cells of the hormone.
She was introduced to genetics research during two paid summer placements — one on genetic variants in oestrogen receptors, the other on the role of a gene called FasL in the rejection of corneal grafts — and those experiences affirmed her interest in the discipline.
Laboratory studies show that, at the right dose, BPA can act as a hormone mimic, binding not only to oestrogen receptors but to other related receptors, too.
Previous large - scale genetics studies have implicated 14 of the 110 genes as playing a role in breast cancer risk, such as the oestrogen receptor gene ESR1, showing that Capture Hi - C is an effective tool for picking up risk genes.
Unlike other cancers, TNBC cells lack three surface receptors normally targeted in treatment, one of them an oestrogen receptor.
Normand and his Matrix Microenvironment & Metastasis laboratory are working on converting TNBC to a subtype of cancer that expresses the oestrogen receptor so it can be targeted by existing anti-oestrogen drugs.
A comprehensive PowerPoint which reviews how Oestrogen triggers gene expression through the oestrogen receptor.
Three Presentations, a double - sided worksheet on epigenetics and a fun class quiz which cover the following topics: Transcription Factors and the Oestrogen Receptor, DNA methylation and Histone Acetylation (epigenetics), RNA interference, as well as how these are implicated in cancers.
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