Sentences with phrase «oestrogen receptor in»

His lab hopes to knock out a specific oestrogen receptor in dogs to understand the hormone's effects on fertility.

Not exact matches

Breast Cancer Care comment on claims that long - term use of Tamoxifen may increase proportion of oestrogen receptor (ER) negative cancers which develop in the opposite breast

«The study shows that long - term use of Tamoxifen does not increase incidence of breast cancer in the opposite breast, but it may increase the proportion of oestrogen receptor negative cancers.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

Because of a quirk of evolution, these plant chemicals are close enough to the natural hormone's shape to bind to the oestrogen receptors on cells in the human body.

Of these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifen.

«We used different groups of mice, in which either the oestrogen receptor or RANKL was inactivated in hematopoietic cells or in mesenchymal cells, to be able to identify the target cells of the hormone.

A lack of oestrogen or the corresponding cell receptors where it can bind results in the overproduction of RANKL, which triggers a variety of pathological bone changes.

One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.

Previous large - scale genetics studies have implicated 14 of the 110 genes as playing a role in breast cancer risk, such as the oestrogen receptor gene ESR1, showing that Capture Hi - C is an effective tool for picking up risk genes.

In addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expressioIn addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expressioin the control of gene expression.

My translational research has focused on trying to find better ways to estimate recurrence risk in patients diagnosed with oestrogen - receptor positive early breast cancer, with the ultimate aim to better personalise our therapies for those patients who have the most to gain from them.

Thesis title: «Predicting the risk of recurrence in oestrogen - receptor positive breast cancer: how precise need we be?»

A role for the androgen metabolite, 5alpha - androstane - 3beta, 17 beta - diol, in modulating oestrogen receptor beta - mediated regulation of hormonal stress reactivity..

The oestrogens that negatively impact on our body either settle in the receptor sites reserved for natural oestrogen production, or can have very damaging effects on the body as the liver attempts to detoxify them.

These are environmental toxins that are absorbed in the blood stream and take up residence in the receptor sites reserved for normal oestrogen activity.

(4) The demonstration of a melatonin receptor in human ovary suggests a direct influence of this hormone on the ovarian function, and possibly oestrogen production.

Three Presentations, a double - sided worksheet on epigenetics and a fun class quiz which cover the following topics: Transcription Factors and the Oestrogen Receptor, DNA methylation and Histone Acetylation (epigenetics), RNA interference, as well as how these are implicated in cancers.