Sentences with phrase «of adipocytes in»

In her study, «Biological Behavior of Adipocytes in Adolescents on Depot Medroxyprogesterone Acetate (DMPA): Is It Related to Weight Gain?

Feeding the HF diet markedly induced hypertrophy of the adipocytes in the epididymal white adipose tissue compared with the control group.

Not exact matches

Differences in release of insulin and other pancreatic and gut hormones have also been observed between breastfed and formula - fed infants, with formula feeding leading to higher plasma levels of insulin which in turn would stimulate fat deposition and early development of adipocytes, the cells that store fat (18).

After 2 years as a resident at the University of Chicago Hospitals, Sargis went to work with Matthew Brady, an endocrinologist in the University of Chicago's Pritzker School of Medicine, studying the development of adipocytes, the cells that store fat.

Sargis has been working in Brady's lab for 2 years now, exploring how environmental pollutants influence the molecular programming of adipocytes.

When macrophages are stimulated with an endotoxin, they produce a factor or factors, termed cachectin, that inhibits the activity of fat - producing (lipogenic) enzymes in cultured adipocytes.

A team led by Antonia Sassmann - Schweda of the Max - Planck - Institute for Heart and Lung Research and colleagues generated mice lacking TAK1 specifically in adipocytes.

Adipocytes do indeed secrete more CCL7 in the case of obesity.

This phenomenon is more frequent in obese patients, in whom the size and number of PPAT adipocyte cells are higher.

An individual's tendency to be pear or apple - shaped may in part be set by the ability of their thigh fat cells to recruit more adipocytes.

The research team from the Department of Biochemistry and Molecular Biology headed by Professor Susanne Mandrup are publishing a paper entitled «Browning of human adipocytes requires KLF11 and reprogramming of PPAR super-enhancers» in the January 1 edition of the scientific journal Genes & Development that describes their results from working with «brite» fat cells.

UCP - 1 is found in mitochondria of adipocytes and plays roles in converting energy into heat, that is, fat burning.

In humans, most are white adipose tissues, and the adipocytes contain a large quantity of neutral fat.

The tissue, called the stroma, includes fat cells, or adipocytes, that provide padding; fibroblasts, which make the framework for tissue; pericytes in blood vessels, which are contractile cells that help regulate blood pressure; as well as myoepithelial cells comprising the outer layer of the ductal system through which milk flows.

«The idea is that when fat cells (adipocytes) interact with environmental agents — in this case, bacterial toxins — they then trigger a chronic inflammatory process,» says Patrick Schlievert, Ph.D., UI professor and head of microbiology and co-senior author of a new study published in the journal PLOS ONE.

The accumulation of adipose tissue macrophages in direct proportion to adipocyte size and body mass may explain the coordinated increase in expression of genes encoding macrophage markers observed in our microarray expression data.

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

The expression rates of three macrophage - specific genes (Emr1, Cd68, and Csf1) that correlated with body mass in our microarray studies, an adipocyte - specific gene (Acrp30), and proinflammatory genes (Tnfa, Nos2, Il6) were determined by quantitative RT - PCR.

That adipocytes express receptors for several proinflammatory molecules (e.g., TNF - α, IL - 6) supports models in which adipocytes were both the source and target of proinflammatory signals.

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice

The close relationship between adipocyte size and the abundance of macrophages in adipose tissue suggests that the influence of adipocyte size on adipocyte function may be conveyed through a paracrine pathway involving adipose tissue macrophages.

Additionally, I am applying similar strategy to create the in vitro model of the inflammation in adipose tissue using iPS - derived adipocytes.

Obesity is accompanied by ectopic lipid deposition in multiple tissues, including the skeleton, where infiltration of adipocytes into the bone marrow niche may negatively impact bone formation (7, 8).

These data demonstrate that variations in continuous quantitative traits such as body mass, adipocyte size, and BMI are correlated with quantitative variations in the expression of genes.

Although the slopes corresponding to adipocyte cross-sectional area for the subcutaneous depot were smaller than (and fell outside the 95 % confidence intervals of) the slopes for the mesenteric and perigonadal depots, this difference was entirely attributable to the fact that the data from three B6.V Lepob / ob mice fell below the line relating adipocyte area to macrophage content in the other animals (Table 1).

In subcutaneous and parametrial adipose tissue, the mean adipocyte size of the FVB / NJ Csf1op / op mice (311 ± 71 μm2) was smaller though not significantly different from that of control FVB / NJ Csf1 + / + mice (476 ± 326 μm2)(P = 0.37).

Average adipocyte cross-sectional area and the percentage of F4 / 80 + cells (macrophages) in adipose tissue depots were determined for each mouse in this study.

In the extremely obese animals, some of these macrophage aggregates completely surrounded adipocytes (Figure 2).

Macrophages in the adipose tissue of lean mice were uniformly small, isolated, and widely dispersed among the adipocytes.

White adipocytes are mainly located in the abdominal and subcutaneous areas of the body and highly adapted to store excess energy.

In mice, both body mass and adipocyte size were strong predictors of the percentage of F4 / 80 + macrophages in the perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue depotIn mice, both body mass and adipocyte size were strong predictors of the percentage of F4 / 80 + macrophages in the perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue depotin the perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue depots.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

The researchers selectively ablated Lsd1 and inactivated its catalytic activity in brown adipocytes, which triggered a profound whitening of brown adipose tissue: The colour of the brown fat cells became paler, their size increased and they started to store energy instead of expending it.

1,25 - dihydroxyvitamin D3 protects against macrophage - induced activation of NF?B and MAPK signalling and chemokine release in human adipocytes.

PPARγ was initially linked to adipocyte (fat cell) differentiation, but we now know that it also regulates genes responsible for lipid uptake, accumulation, and storage of lipids in those cells.

Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3 - L1 Adipocytes.

Prolonged decrease of adipocyte size after rosiglitazone treatment in high - and low - fat - fed rats.

In his study, Wang found that pups born to mother mice fed a triple dose of Vitamin A were born with more fat - burning brown fat cells, and had more small blood vessels in their adipose tissues, providing precursor cells for energy - burning beige adipocytIn his study, Wang found that pups born to mother mice fed a triple dose of Vitamin A were born with more fat - burning brown fat cells, and had more small blood vessels in their adipose tissues, providing precursor cells for energy - burning beige adipocytin their adipose tissues, providing precursor cells for energy - burning beige adipocytes

N - glycosylation is important for efficient trafficking of GLUT4 to its proper compartments in adipocytes (51), suggesting one mechanism by which dysregulation of these genes could contribute to T2D.

(3,18; cf. 19,20) Even in visceral fat, it has recently emerged that the obesity - driven rise in inflammation and insulin resistance is associated with an abnormal accumulation of senescent cells, albeit senescent endothelial cells rather than adipocytes.

In individuals with T2D, this function is frequently perturbed by an impaired response of the adipocytes to insulin resulting in elevated lipid levels in circulation and storage in alternative tissues such as liver, muscle, and pancreas (3In individuals with T2D, this function is frequently perturbed by an impaired response of the adipocytes to insulin resulting in elevated lipid levels in circulation and storage in alternative tissues such as liver, muscle, and pancreas (3in elevated lipid levels in circulation and storage in alternative tissues such as liver, muscle, and pancreas (3in circulation and storage in alternative tissues such as liver, muscle, and pancreas (3in alternative tissues such as liver, muscle, and pancreas (3).

The regulation and activatin of ciliary neurotrophic factor signaling proteins in adipocytes.

Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice.

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

Complete loss of mitochondrial CLPP protease protects mice from diet ‐ induced obesity and insulin ‐ resistance but impairs cold ‐ induced thermogenesis due to a decline in brown adipocyte function.

Our research focuses on hypothalamic mechanisms necessary for regulating body weight and second the role of the adipocyte hormone leptin in promoting breast cancer.

Joslin scientists are actively involved in studying the regulation of the many factors that control the storage, mobilization and utilization of excess energy in adipocytes (fat cells).

In 2016 Schulz was appointed head of the department of «Adipocyte Development and Nutrition «at the DIfE, a partner of the German Center for Diabetes Research (DZD).

After 14 days of hyperleptinemia, adipocytes had become shrunken, fatless, and encased in a thick basement - membrane - like matrix.