Sentences with phrase «of apolipoprotein»

A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late - life moderated by the environment

Intake of flaxseeds has also been shown to decrease the ratio of LDL - to - HDL cholesterol in several human studies and to increase the level of apolipoprotein A1, which is the major protein found in HDL cholesterol (the «good» cholesterol).

ApoE - 4, a particular allele of the apolipoprotein apoE, is a known risk factor.

Increased amyloid β - peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late - onset Alzheimer disease.

Our laboratory focuses on the structure and function of apolipoprotein (apo) E, including its critical role in cholesterol homeostasis, atherosclerosis and neurodegenerative disorders such as Alzheimer's disease and traumatic brain injury.

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

Led by Michael Holzer at the Institute of Experimental and Clinical Pharmacology, the research team went on to determine that «prolonged freezing at -20 °C or -70 °C led to a shedding of apolipoprotein - AI from HDL and to the formation of large protein - poor particles, indicating that HDL is irreversibly disrupted.»

E-Scape Bio is now developing small - molecule drugs that target the primary genetic cause of Alzheimer's disease by correcting adverse effects of the apolipoprotein E4 (apoE4) gene.

These NIH - funded studies investigate the role of Apolipoprotein F (ApoF) in regulating cholesterol transport.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

Understanding the Role of Apolipoprotein E in Microglia Edoardo Marcora, PhD Icahn School of Medicine at Mount Sinai (New York, NY)

Using a small fragment of apolipoprotein B as a guide, Brian Spencer, a postdoctoral fellow in the Verma lab and the study's lead author, successfully shepherded the enzyme glucocerebrosidase into the brains of adult mice.

The goal of this project is to elucidate the functional role of apolipoprotein E (APOE) in microglia, the resident immune cells of the brain.

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction.

Dr. Huang studies the origin and development of Alzheimer's disease, focusing on the pathological role of apolipoprotein E4 (apoE4)-- the major genetic risk factor for Alzheimer's.

So, the researchers attached a fragment of apolipoprotein B to glucocerebroside, hoping that it would transport the enzyme into the brain.

Expression of apolipoprotein E mRNA in the epithelium and interstitium of the testis and the epididymis.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

A large - scale genetic analysis in PSP patients, however, identified a common tau sequence that increases by 5.5 times a person's chances of developing the disease, making this variant a stronger risk factor for PSP than one copy of the apolipoprotein E-ε4 variant is for Alzheimer's.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

The abnormal composition of apolipoproteins (apo) in the lipoprotein fractions from the patient (P) is compared with the compositions of his mother (M) and a normolipidemic control participant (C).

Not exact matches

Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL - cholesterol, and apolipoprotein - B in young men and women

Apolipoprotein E is a protein that is important in the repair and recovery of brain cells that have been damaged due to concussion.

HDL with a small proinflammatory protein called apolipoprotein C - III (apoC - III) on its surface may nearly double the risk of heart disease in healthy men and women, according to Frank Sacks, professor of cardiovascular disease prevention at the Harvard School of Public Health and senior author on a paper in the April Journal of the American Heart Association.

In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

In «Greater Cognitive Deficits with Sleep - Disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis,» researchers report that study participants carrying the apolipoprotein?

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

«Approximately 15 percent of the human population carries apolipoprotein APOE4.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

With the same diet pattern, levels of LDL cholesterol and apolipoprotein B (a secondary end point) increased, with no changes in HDL cholesterol or triglyceride level or blood pressure.»

Instead, a blood protein known as apolipoprotein B (apoB) is a truer indicator of the threat to our arteries, the doctors say.

Until recently, only one gene variant, Apolipoprotein E-e4 (APOE - e4), had been confirmed as a significant risk factor gene for the common form of late - onset Alzheimer's disease, which typically occurs after age 60.

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

Nox2 modification of LDL is essential for optimal apolipoprotein B - mediated control of agr type III Staphylococcus aureus quorum - sensing.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid - beta (Aβ) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains.

The editors of JLR will pay close attention to the Spotlight Talks, as the journal is just wrapping up an eight - review series on the major risk factor for Alzheimer's disease, apolipoprotein E, and it's time to get inspired for the next one.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

The interest intensified several years ago with the surprising discovery that an increased risk of Alzheimer's disease was linked to a natural genetic variant of a key fat - transporter molecule called apolipoprotein E, or apoE.

Two renal - risk variants in the apolipoprotein L1 gene (APOL1), termed G1 and G2, are present in a large percentage of African American organ donors and kidney transplant recipients.