Natesan S, Wrice NL, Baer DG, et al., Debrided Skin as a Source
of Autologous Stem Cells for Wound Repair.
Not exact matches
«If we win, the entire regulatory structure for
autologous cell processing, with or without culture, will be rewritten such that any physician using good practices and treating patients responsibly can use
stem cells as part
of his or her medical practice,» he says.
The study, «Lenalidomide (LEN) maintenance (MNTC) after high - dose melphalan and
autologous stem cell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, Jun
cell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA)
of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma
Cell Dyscrasia oral abstract session Friday, Jun
Cell Dyscrasia oral abstract session Friday, June 3.
«Lenalidomide maintenance following
autologous stem cell transplant can now be considered a standard
of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator
of the U.S. study, CALGB (Alliance) 100104.
Results from a clinical trial investigating a new T
cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer
cells demonstrated a clinical response in 80 percent
of multiple myeloma patients with advanced disease after undergoing
autologous stem cell transplants (ASCT).
In particular, they allege that news
of the investigations, which came to light this past April, cost them millions
of dollars by derailing a deal to sell their
stem cell company,
Autologous / Progenital, and took them out
of the running for lucrative faculty positions.
«Previous studies have shown that a threshold percentage
of limbal
stem cells (which are responsible for replenishing the cornea) is required for successful corneal
autologous therapy,» says co-first author Tom Bongiorno, a graduate student in bioengineering at Georgia Tech.
The treatment in the current study, called
autologous hematopoietic
stem cell transplantation (AHSCT), was given to patients with advanced forms
of the disease that had failed to respond to other medications.
Pattern
of employment and associated factors in long - term lymphoma survivors 10 years after high - dose chemotherapy with
autologous stem cell transplantation.
«
Autologous stem cell transplant should be standard care for HIV - associated lymphoma: Multicenter, Phase II trial suggests autologous transplant should be standard of care for HIV patients with relapsed / treatment - resistant lympho
Autologous stem cell transplant should be standard care for HIV - associated lymphoma: Multicenter, Phase II trial suggests
autologous transplant should be standard of care for HIV patients with relapsed / treatment - resistant lympho
autologous transplant should be standard
of care for HIV patients with relapsed / treatment - resistant lymphoma.»
However, these problems associated with histocompatibility may be solved using
autologous donor adult
stem cells, therapeutic cloning,
stem cell banks or more recently by reprogramming
of somatic
cells with defined factors (e.g. induced pluripotent
stem cells).
Although many immunosuppressive strategies have failed, the recent use
of autologous hematopoietic
stem and progenitor
cell (HSPC) transplantation has shown therapeutic promise.
Based on our data,
autologous stem cell transplant should be considered the standard
of care for patients with HIV - related lymphomas for the same indications and under the same circumstances that we would use it in patients without HIV infection.»
In addition, transgenic
autologous hematopoietic
stem cells can be successfully transplanted in HIV - infected individuals [18] and several phase I adoptive transfer trials
of CD4 + T
cells treated with R5 - ZFNs in HIV infected individuals are currently underway.
However, coreceptor - specific ZFNs represent a novel therapeutic approach to recapitulate this success via
autologous transplantation
of gene - modified hematopoietic
stem cells and mature CD4 + T
cells.
Vision Loss after Intravitreal Injection
of Autologous «
Stem Cells» for AMD.
In close collaboration with universities and physicians world - wide, our comprehensive investigational
stem cell treatments employ well - targeted combinations
of allogeneic human umbilical cord
stem cells,
autologous bone marrow
stem cells, and
autologous adipose
stem cells for the diseases listed below.
In a previous study by the same group 78,
autologous culture - expanded MSC were infused to breast cancer patients to investigate whether MSC would enhance the engraftment
of peripheral blood
stem cells after myeloablative therapy.
Ed Field currently is the Chief Operating Officer
of Cytomedix, Inc. (OTCBB: CMXI), a US - based company that is developing and commercializing
autologous regenerative biotherapies that promote healing by harnessing the innate regenerative capacity
of platelets and adult
stem cells.
For the first time, researchers demonstrate long term success
of a
cell replacement therapy using
autologous induced pluripotent
stem cell derivatives
In 2016, the Food and Drug Administration (FDA), the branch
of government charged with regulating cellular therapies, took action to address these issues, proposing revised guidelines that could change how
stem cells, especially
autologous stem cells, are regulated.
Biological markers
of Mesenchymal Stromal
Cells as Predictors
of response to
Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study.
Around 5 - 10 %
of patients with solid tumors who are treated with chemotherapy, radiation or
autologous stem cell transplantation develop treatment - related MDS or AML.
In this study, Peterson and colleagues have tried to recapitulate aspects
of Brown's treatment using gene editing and
autologous stem cell transplant.
The US Food and Drug Administration (FDA) has granted Priority Review designation for tisagenlecleucel (Kymriah), formerly known as CTL019, for treatment
of adult patients with relapsed or refractory diffuse large B -
cell lymphoma (DLBCL) who are ineligible for, or have relapsed after,
autologous stem cell transplant.
Towards the clinical translation
of intra-articular injection
of MSCs, the group
of Kang Sup Yoon at the Seoul National University College
of Medicine, Seoul, Korea report on their a proof -
of concept phase I / II clinical trial intra-articular injection
of autologous adipose tissue derived mesenchymal
stem cells (AD MSCs)[6].
Review
of «Biological markers
of Mesenchymal Stromal
Cells as Predictors
of response to
Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study» from
Stem Cells by Stuart P. Atkinson
His current focus is on the production
of autologous hepatocytes from patient - derived induced pluripotent
stem cells (iPSCs).
The therapy from Trinity Clinic Fukuoka involves 10 intravenously administered doses
of 200 million
autologous adipose tissue - derived mesenchymal
stem cells.
Thus, for the specific example you gave
of using
autologous bone marrow
stem cells injected into the brain, this scenario would indeed require full FDA approval as it does not meet the criteria
of homologous use, as you said.
Patients receive one
of two types
of stem cell - based transplants:
autologous, in which a patient donates and receives back his / her own
stem cells; or allogeneic, in which bone marrow - derived
stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those
of a patient.
I was diagnosed with non-Hodgkin's diffuse B -
cell lymphoma on Aug. 14, 2015, and since then, I have undergone three rounds
of chemotherapy, 22 radiation treatments and an
autologous stem cell transplant.
High - Dose Chemotherapy Plus Transplant Not Recommended for DLBCL: The results
of an Italian study report that treatment
of high - risk diffuse large B -
cell lymphoma (DLBCL) with abbreviated course
of rituximab dose - dense chemotherapy plus high - dose cytarabine, mitoxantrone, and dexamethasone (R - MAD) plus carmustine, etoposide, cytarabine, and melphalan (BEAM) plus
autologous stem cell transplantation compared with a full course
of rituximab dose - dense chemotherapy did not improve overall survival.
That happened right before my
autologous stem cell transplant, after I'd done one more round
of chemotherapy before my
stem cells were harvested.
The technique involves replacing a mutated copy
of the gene with a healthy copy in
stem cells isolated from the patient, which are then transfused back into the body — a process known as
autologous stem cell transplantation.
This is the «show reel»
of Dr Haluk Deda, a Turkish neurosurgeon who is setting up shop in Dubai, where he plans to offer
autologous stem cell transplants to treat chronic spinal cord injuries and ALS, a condition with no known cure that generally leads to death within three to five years
of diagnosis.
Additionally, the head
of a prominent human embryonic
stem cells firm (Geron) has publicly questioned the viability
of commercialized therapeutic applications
of autologous hiPSCs due to the regulatory requirements imposed by the US Food and Drug Administration [7].
Unmatched performance — high transfection efficiency &
cell viability in primary cells Fully scalable — from R&D to the clinic without reoptimization Safe — non-viral cell engineering in closed, sterile, computer - controlled environment Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins, cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - ma
cell viability in primary
cells Fully scalable — from R&D to the clinic without reoptimization Safe — non-viral
cell engineering in closed, sterile, computer - controlled environment Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins, cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - ma
cell engineering in closed, sterile, computer - controlled environment
Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins, cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - ma
Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins,
cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - ma
cell lysates, and small molecules into
autologous or allogenic immune,
stem / progenitor, or somatic
cells Regulatory ease — Master File designation with the CBER Division
of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - marked
Transplants types are categorized by the source
of the donor:
Autologous transplants: Patients receive their own
stem cells.
The strongest challenge to this approach, granting the periodic replenishment
of somatic
stem -
cell pools with
autologous but OncoSENS - ready
stem cells, has been the possible existence
of functions
of TERT (telomerase reverse transcriptase — the catalytic subunit
of telomerase), other than the lengthening
of telomeres itself.
It is an
autologous limbal
stem cell composite graft, prepared from the limbal biopsy excised from the healthy eye
of the patient.
Their research focused on evaluating the safety and efficacy
of autologous bone marrow - derived
stem cell transplantation in individuals with type 2 diabetes with good glycemic control as well, which emerged as an important aspect in the transplantation group as well as in the non-transplanted group.
Two promising new area for Hashimoto's treatment: the use
of the drug low dose naltrexone (LDN) and
autologous stem cell transplants.
The other type
of therapy is
autologous mesenchymal
stem cell transplantation.
One type
of stem cell transplant,
autologous hematopoietic
stem cell transplantation, uses
stems cells from your own bone marrow, or from external umbilical cord blood.
Autologous Adult
Stem Cells are being used to treat many types
of chronic pain and degeneration.
We utilize
autologous adipose tissue for the source
of stem cells.
Title: Transplantation and Tracking
of Autologous Epidermal Neural Crest
Stem Cells into the Spinal Cord
of Dogs with Acute Severe Spinal Cord Injury
Vet -
Stem Regenerative Medicine uses a concentrated form of autologous adipose - derived adult stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs and c
Stem Regenerative Medicine uses a concentrated form
of autologous adipose - derived adult
stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs and c
stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs and cats.
We use
autologous fat derived
stem cells (also called adult
stem cells, mesenchymal
stem cells, stromal vascular fraction
stem cells...) which are from the pet itself so there is little likelihood
of any untoward reaction.