Sentences with phrase «of brain tumor cells»

Authored and submitted a paper for publication, «The Behavior of Brain Tumor Cells Extracted From the Pineal Gland Under Spectrum Shifts of UV Light»

Not exact matches

These CAR - T cells were able to penetrate the blood - brain barrier, one of the major hurdles in treating brain tumors.

Triple negative patients usually have shorter survival time after diagnosis of brain metastasis, suggesting that these tumor cells adapt much more readily once they've moved to the brain.

So far, researchers with the Allen Institute for Brain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve cells, or neurons, taken from the brains of 36 patients as they underwent surgery for conditions such as brain tumors or epilBrain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve cells, or neurons, taken from the brains of 36 patients as they underwent surgery for conditions such as brain tumors or epilbrain tumors or epilepsy.

In many patients diagnosed with LUAD, tumors cells have already spread to the brain, leading to decreased quality of life and low survival rates.

«Few drugs have the capacity to cross the tumor blood - brain barrier and specifically target tumor cells,» says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC — James.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

«This drug was able to re-activate the disabled microglia,» says Sarkar, «thus restoring the body's natural defense mechanisms and restricting the growth of brain tumor initiating cells.»

DIPGs are known as one of the most challenging tumors to treat because cancer cells are intimately intermingled with normal brain cells in a part of the brain that can not be surgically resected.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Because it treats the whole brain, the therapy is thought to control the spread of tumors by treating both identifiable and hidden cancerous cells.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

Reducing STK17A also interfered with tumor cells» ability to move around and invade other areas of the brain.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

But following the removal of the primary tumor, micrometastatic cells learn to communicate with cells in their new microenvironment in the brain — cells which are, at first, hostile to them.

We found that the inflammation unfortunately gets hijacked by tumor cells that are able to grow faster and penetrate deeper because the blood vessels in the brain are more permeable than in any other part of the body.

Published in Molecular Neurobiology, the study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime - Morawek, Lecturer in Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cCells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cellscells.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

Dr. Del Maestro adds, «Yong and colleagues at the University of Calgary have begun to unravel the complex interaction of the microglia with the brain tumor cells, resulting not only in furthering our understanding, but providing a new concept and drug which can now be immediately assessed in clinical trials.»

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

Nagoya University - led research team shows in mice the potential of a special immune cell that targets a key protein in tumor growth that helps stop brain cancer.

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

A preclinical study shows that an experimental nanotechnology drug called SapC - DOPS crosses the tumor blood - brain barrier, targets brain - tumor cells and retards growth of tumor blood vessels.

The researchers took this discovery and, in an animal model, identified a drug that is able to re-activate those immune cells and reduce brain tumor growth, thereby increasing the lifespan of mice two to three times.

If we can boost the immune system and allow microglia to do their job and control brain tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

«We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain, and other organs.

Interphone compared surveyed cell phone use in 6,420 people with brain tumors to that of 7,658 healthy people in 13 developed countries — Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden and the U.K. — to try to determine whether people with brain tumors had used their cell phones more than healthy people, an association that might suggest that cell phones caused the tumors.

The cells in such a brain tumor can display very different characteristics, such as varying cell size or number of cell nuclei.

Scientists at Barrow Neurological Institute have recently made discoveries about use of a new technology for imaging brain tumors in the operating room — a finding that could have important implications for identifying and locating invading cells at the edge of a brain tumor.

Images of the tumor cells are immediately created on an LCD screen observed as the surgeon scans the instrument across the tumor or brain surface.

There is plenty of anecdotal evidence out there claiming a link between cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the brain cancer (malignant glioma) that killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent cell phone use, based on the fact that the tumor developed on the side of the head against which he held his phone.

A team of researchers in northern Europe, however, has now combed through three decades of cancer registries and found no increase in the rate of brain tumors in the five to 10 years following widespread cell phone adoption in that region.

«Long term and frequent use of cell phones which receive and emit radio frequency may be associated with an increased risk of brain tumors,» Herberman told lawmakers.

His research largely focuses on new means to incorporate imaging methods to view cells of brain tumors with a hand held instrument that a neurosurgeon can use to visualize the individual cells during the progress of the operation.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

Subsequent surgery on vaccinated patients has shown that the T cells are finding and killing tumor cells in the brain, but not enough of them.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

Physical pushes and pulls on a cell, not just genes, determine whether it will become part of a bone, a brain — or a deadly tumor

The idea has been controversial, but three papers published today report evidence that in certain brain, skin, and intestinal tumors, cancer stem cells are the source of tumor growth.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

A molecule that helps cells stick together is significantly over-produced in two very different diseases — rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study.

Now he and his team are putting cells from human brain tumors into the organoids, which have reached the level of development and complexity of a 20 - week - old human fetus's, to see whether they reprise what happens in patients.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.