Effect of Alpha - lipoic Acid on the Progression
of Endothelial Cell Damage and Albuminuria in Patients with Diabetes Mellitus: An Exploratory Study Diabetes Res Clin Pract 2001 (Jun); 52 (3): 175 — 183 Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus.
In this prospective, open and non-randomized study, the effect of alpha - lipoic acid on the progression
of endothelial cell damage and the course of diabetic nephropathy, as assessed by measurement of plasma thrombomodulin and urinary albumin concentration (UAC), was evaluated in 84 patients with diabetes mellitus over 18 months.
Not exact matches
Researchers from the UNC School
of Medicine have discovered that
cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into
endothelial cells, which generate blood vessels to supply oxygen and nutrients to the injured regions
of the heart, thus greatly reducing the
damage done following heart attack.
Professor Takao Hamakubo's group at the Department
of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), have shown that PTX3 forms strong bonds with histones and partially unfolds, leading to a disordered coaggregation
of histone and PTX3 and protecting human
endothelial cells from
damage.
The force
of that blood flow helps keep the
cells that line the blood vessels, called
endothelial cells, healthy; when blood flow is disrupted, such as during surgical procedures or a stroke, the vessels start to leak, which can cause a host
of inflammatory responses that lead to
cell damage and disease.
If we understand the special features
of insulin resistance in
endothelial cells, we may be able to find more effective treatments against artery
damage and cardiovascular disease in people with diabetes.»
We will combine methods from the fields
of immunology, developmental biology and angiogenesis to understand in vivo the development and lineage - specific function (s)
of resident macrophages, thereby opening new venues
of research into the interaction between macrophages and
endothelial cells in response to tissue
damage.
Additionally, there was no
damage to the
endothelial cells of untargeted organs.
At the same time, the protein Vascular
Endothelial Growth Factor (VEGF) stimulates blood supply for the
damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the
damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem
Cell Factor (SCF) stimulates your native inactive stem
cells to become activated and assist in the repair
of the
damaged tissue.
Researchers at the University
of Palermo in Italy found that the betalains contained in prickly pears appears to protect the
endothelial cell walls
of blood vessels from oxidative
damage by free radicals.
/ consuming Animal proteins cause numerous proteins as it is not designed for us / may be designed to grow that animal at a rate much faster than we are designed for / and also feeds the growth
of Cancer
cells /
damages the
Endothelial cells / ala Dr. Esselstyn and others.