Sentences with phrase «of epigenomics»

This fascinating field of epigenomics examines how genes are modified without changing the DNA sequence — that is, how a gene for obesity, for instance, is modified by eating nonstarchy vegetables versus cupcakes.

But there is a developing school of research, the study of epigenomics, that seeks to help explain how the interaction of our genes and environment causes disease.

In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.

Variations in methylation between healthy and ailing tissues «might give us a better understanding of what goes wrong» in some diseases, says Alexander Olek of Epigenomics, a biotech start - up in Berlin.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

Ecker discovered that a kind of epigenomic regulation found first in plants are also present in mammalian brain cells.

Not exact matches

DURECT Corp. is a biopharmaceutical company focused on two areas of active drug development: New therapeutics based on its proprietary drug delivery platforms and new chemical entities derived from its epigenomic regulator program.

This study opens new avenues of research aiming at integrating genomic and epigenomic data together with environmental exposures in order to elucidate the physio - pathological mechanisms underlying asthma and to promote the development of new therapies.

In 2008 the National Institutes of Health launched the $ 190 - million Roadmap Epigenomics Project with the goal of cataloguing the epigenetic marks in the major human cell types and tissues.

«However, there is emerging evidence that epigenomic changes such as DNA methylation and histone modifications, which affect the ways in which genes are transcribed and translated into proteins, are important features of these processes,» he continues.

The crew of researchers involved in the Roadmap Epigenomics Project premiered their findings in more than 20 scientific papers published in February (SN: 3/21/15, p. 6).

He is now an associate professor at Weill and director of its WorldQuant Initiative for Quantitative Prediction, as well as leader of the U.S. Food and Drug Administration's SEQC2 Epigenomics Quality Control Working Group.

Epigenomics offers insights into the complex, multilayered system of genome regulation.

Dr Simone Ottonello, from the University of Parma, Italy says: «If extended to black truffles from different geographic areas, epigenomic analyses, such as the one described in this work, may shed light on the relationships between DNA methylation and transposon - mediated genome shaping, intraspecific variability and commercially relevant organoleptic traits such as aroma and color»

Residing in large numbers outside the nucleus of every cell, mitochondria contain their own DNA, with unique features that «may require a reassessment of some of our core assumptions about human genetics and evolutionary theory,» concludes Wallace, director of the Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia.

Epigenomic profiling of complex tissues obscures regulatory elements that distinguish one cell type from another, researchers report.

The overall goal of the TGen study was to look at genomic and epigenomic events to understand the causes of breast cancer brain metastatic lesions, and identify potential new therapeutic targets.

The study, Integrated Genomic and Epigenomic Analysis of Breast Cancer Brain Metastasis, published Jan. 29, is the first of its kind to incorporate all of those avenues of inquiry in the study of this disease.

The maps and discoveries made after examining them are being published February 18 in more than 20 scientific papers in Nature and affiliated journals by a large consortium of researchers involved with the Roadmap Epigenomics Project.

To truly understand the complexities of their biology requires a combination of genomic, epigenomic, and functional analysis.

Techniques have been developed over the last decade to allow for «epigenomics,» the genome - wide characterization of methylation patterns.

The result is an epigenomic road map that links diseases and traits (red dots) with the locations in the body (white dots) of the switches most correlated with those features; thicker lines correspond to more robust links.

The Epigenomics Roadmap, the ENCODE Project, and other functional genomics initiatives are just so vital as we expand our search for phenotypically - relevant variants outside of the coding regions.

Next, the authors turned to their other epigenomic profiling datasets — DNA accessibility (DNAse - Seq), methlation (bisulfite sequencing), and RNA transcription (RNA - Seq) to examine and compare the properties of these chromatin states.

Moreover, the regional susceptibility and tolerance to a particular mutation type is a mixture of various genomic and epigenomic features and selective pressures [64].

The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

John Greally, faculty scholar for epigenomics At Albert Einstein College of Medicine tweeted:

Reference Marks et al., The Transcriptional and Epigenomic Foundations of Ground State Pluripotency, Cell (2012), doi: 10.1016 / j.cell.2012.03.026 Read a review of this paper: Guenther MG and Young RA (2012).

Masafumi now leads his own group at the University of Tsukuba in Japan, with a focus on genomics and epigenomics of clinical samples.

He is the author of over 160 research papers, inventor of 24 patents and patent applications, founder of 4 biotech companies (Genom Analytik GmbH, Biopsytec GmbH and Epigenomics AG, Integragen SA).

Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.

The Translational Genomics and Epigenomics Laboratory is part of the Olivia Newton - John Cancer Research Institute.

Researchers are building a database of DNA sequence, functional and epigenomic information, and clinical data from studies on type 2 diabetes and its macro - and microvascular complications, and creating analytic tools to analyze these data.

Omics techniques employed in our group range from whole genome sequencing and epigenomic techniques, to single cell / single strand DNA sequencing (Strand - seq; see Figure 1), the latter of which enables haplotype - resolved studies of genetic variation and genome instability.

The SEMM organizes international events for the promotion of research and dissemination of results in relatively broad scientific areas such as Molecular Oncology, Molecular Medicine, Epigenomics, and Biomedical Humanities.

IHEC aims to provide researchers with a comprehensive epigenomic analysis of healthy and abnormal cells, and the new studies constitute major strides toward that goal.

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

«The McMurdo Dry Valleys in Antarctica are the closest terrestrial analog we have to what's happening on other planets,» says David Goerlitz, director of operations for the Genomics and Epigenomics Shared Resource at Georgetown University Medical Center.

Once finished, however, an epigenomic map could also prove useful in determining which individuals are at risk for certain diseases and encouraging the kind of lifestyle changes that can prevent the wrong genes from switching on or off.

The Vijayanand lab has developed a number of genomics (transcriptomic, single - cell and epigenomic) and immunological assays to enable research with small numbers of cells and small - volume clinical samples.

The Cancer Genome Atlas Research Network (2013) Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia.

Research Focus: I am involved in the analysis of transcriptomic and epigenomic data in various types of human immune cells and in different diseases.

Epigenomic analysis of primary human T cells reveals novel enhancers associated with Th2 memory differentiation and asthma susceptibility.

Our objective is to generate a resource that facilitates research into human immune - related diseases by creating a comprehensive database of cell type - and allele - specific epigenomic and transcriptomic data for the immunology community.

The Cancer Genome Atlas is using genomic, transcriptomic, and epigenomic measurements of cancer cells, coupled with computational approaches and rich clinical data, to understand the dysfunctions that underline the onset, progression, and spread of cancer.

His primary research interests are bioinformatics, computational biology, machine learning, and integrative analysis of high throughput sequencing data with an emphasis on regulatory genomics and epigenomics.

She is Chair of the Scientific and Medical Advisory Board and serves on the Board of Trustees of The United Mitochondrial Disease Foundation (UMDF); founding member of the CHOP Center for Mitochondrial and Epigenomic Medicine (CMEM); CHOP - site PI of the North American Mitochondrial Disease Consortium (NAMDC); member of the Mitochondrial Medicine Society (MMS), Society for Pediatric Research (SPR), Society for Inherited Metabolic Disease (SIMD), American Society of Human Genetics (ASHG), and American College of Medical Genetics and Genomics (ACMGG); and elected member of the University of Pennsylvania John Morgan Society (JMS), Interurban Clinical Club (ICC), and American Society of Clinical Investigators (ASCI).

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

16) Lockwood WW †, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna J, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL (2012) Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.