Sentences with phrase «of heterozygosity»

Khiabanian H, Hirshfield KM, Goldfinger M, Bird S, Stein M, Aisner J, Toppmeyer D, Wong S, Chan N, Dhar K, Gheeya J, Vig H, Hadigol M, Pavlick D, Ansari S, Ali S, Xia B, Rodriguez - Rodriguez L, Ganesan S. Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High - Depth, Tumor - Only Sequencing Data.

ASHG 2008: In - Common Loss of Heterozygosity in 3 Carcinomas May Guide Treatment Medscape Medical News - Nov 20, 2008

Some draft assemblies of the C. krusei genome had been produced prior to these researchers» work, but they were fragmented, a problem caused by a large amount of heterozygosity.

The evolutionarily enigmatic gray whale (Eschrichtius robustus) is placed among rorquals, and the blue whale genome shows a high degree of heterozygosity.

Demonstration of loss of heterozygosity by single - nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection.

Some 22 patients with a homozygous recessive variant were also noted to have one or more regions of «absence of heterozygosity» in their genomes.

362/11: 15 Insights, mechansims, and fundamental significance of copy - neutral loss of heterozygosity detected in oncology samples.

Ryan's group used a mouse model of embryonic homologous deletion of p53, while Kimmelman's group used a loss of heterozygosity mouse model of p53 (closer to human tumors).

The 50K array was used when the rate of heterozygosity was calculated for US Shar - Pei separately and for a reference group of 24 other breeds.

Contrasting effects of heterozygosity on survival and hookworm resistance in California sea lion pups.

Researchers from BGI reported the most complete haploid - resolved diploid genome (HDG) sequence based on de novo assembly with NGS technology and the pipeline developed lays the foundation for de novo assembly of genomes with high levels of heterozygosity.

Often, we know this in advance, either because the parents know they're related, or a SNP array revealed less than the expected amount of heterozygosity (variability between chromosomes).

A common feature is the extensive loss of heterozygosity, which represents an essential source of inter-individual variation in this mainly asexual species.

In oncology terms, this double - hit status is called «loss of heterozygosity,» or LOH, to signify that both versions (one from mom, one from dad) of the normal BRCA gene have been hobbled.

And they found that yeast has suffered from a loss of heterozygosity, in which there are two distinct alleles of a given gene present.

Some notable conclusions from the authors include: diploids are the most fit ploidy; copy number variation (CNV) is the most prevalent type of variation; most single nucleotide polymorphisms (SNPs) are very rare alleles in the population; extensive loss of heterozygosity is observed among many strains.

Thus, tumors with loss of heterozygosity (LOH) at 9p21 - the chromosomal location of p16 - should have a high frequency of intragenic mutations in the other allele that block gene function.

It is well known that the genomes of tumor show extensive loss of heterozygosity (LOH).

Previous studies reported that there is a reduction or loss of expression of the APC protein in 40.7 % of primary human breast cancers (Ho et al., 1999), and it appears to be more often due to promoter methylation (36 - 54 %) and loss of heterozygosity (LOH)(23 %) than to somatically acquired APC mutations in human breast cancers (Sarrio et al., 2003, Jin et al., 2001, Banerji et al., 2012, 2012).

In a study that assessed the relationship of coefficients of inbreeding, and genomic microsatellite typing, to inherited disorders, the authors found «no clear correlation between the level of heterozygosity and the incidence or severity of the disease» [33].