These molecular subtypes have recently been confirmed in a comprehensive characterization
of human breast tumors at the genomic, epigenetic, transcriptomic, and proteomic levels (Cancer Genome Atlas Network, 2012).
Not exact matches
The researchers «deserve a lot
of credit» for testing the approach in the mice that spontaneously develop
breast tumors, he says, which more closely mimic how cancer arises in
humans.
Oncologists William Hahn, Robert Weinberg, and colleagues at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part
of the enzyme and inserted it into cultured
human cells from colon, ovary, and
breast tumors.
Researchers have isolated exosomes from
tumors and from blood
of patients with
breast cancer, and from blood
of mice with
human tumors grown after
breast implantation in mice, called ortoxenogratfs.
Compared to a control (left), epalrestat treatment (right) reduces the number
of metastatic
tumors (arrowheads) in the lungs
of mice injected with
human basal - like
breast cancer cells.
«We knew ZMYND11 was a candidate
tumor - suppressor because it's down - regulated in a number
of human cancers, including
breast cancer,» Shi said.
Horvath and Tell's research is the first reported study to compare
breast cancer subtypes and gene expression patterns associated with STAT3 in the
tumors of human patients.
In earlier studies involving animal models and
human cancer cell lines, researchers found that
breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type
of cell that lines the blood vessels), a perivascular macrophage (a type
of immune cell found near blood vessels), and a
tumor cell that produces high levels
of Mena, a protein that enhances a cancer cell's ability to spread.
The title
of the paper is «Bioinformatic analysis reveals a pattern
of STAT3 - associated gene expression specific to basal - like
breast cancers in
human tumors.»
To test this idea, the researchers utilized two mouse models
of human breast cancer metastasis and found dormant disseminated
tumor cells residing upon the membrane microvasculature
of lung, bone marrow and brain tissue.
In this study, the researchers tested the effects
of Olaparib on the
tumors formed by
human breast cancer cells injected into mice.
The resulting «map»
of gene - drug interactions allowed the researchers to accurately predict the responses
of multiple
human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response
of breast and ovarian
tumor cells to common classes
of chemotherapy treatment.
Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth
of human breast cancer cells in lab dishes and
breast cancer
tumors in mice.
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary
tumor samples from 26 different preclinical models and was able to compile one
of the largest databases to show which strains
of mice were best suited to study a particular type
of human breast cancer.
Human breast tumors transplanted into mice are excellent models
of metastatic cancer and are providing insights into how to attack
breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School
of Medicine in St. Louis.
Using cultured cells derived from
human tumors of the
breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other
tumor types.
Humans have an ortholog
of the murine Nrk gene, and considering that the gene expression pattern in
breast tumor in Nrk mutant mice was similar to that in
human luminal B
breast cancer, the findings
of this study may lead to further understanding
of the mechanisms
of human breast cancer suppression and to advances in its diagnosis and therapy.
Additionally, overexpression
of POSTN in
human mammary epithelial and
breast cancer cells resulted in enhanced
tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression
of POSTN resulted in an increase in the number and size
of liver metastases (Bao et al., 2004).
Further research uncovered a broad spectrum
of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification
of CSCs in
human solid
tumors, including brain,
breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).
Now, in Stem Cells Translation Medicine, the group
of Shu Wang at the National University
of Singapore describe the derivation
of EPCs from
human iPSCs, their therapeutic modification, and their ability to inhibit
tumor growth in a mouse
breast cancer model [4].
Unlike previous MRI studies
of tumors in mice, the researchers were able to detect very small naturally occurring cancers, which were excellent models for
human breast cancer; the
tumors the mice developed were «realistic models
of the most frequently detected
human cancers,» the authors wrote.
It has been reported that
human breast CSCs and normal
human mammary stem / progenitor cells showed decreased expression
of miR200c and other miR200 members and that restoring miR200c in
breast CSCs inhibits their ability to expand clonally and form
tumors in vivo [38].
Rudensky's team compared Tregs in normal
human breast tissues with those found in untreated
breast tumors, and found that Tregs in
tumors were capable
of more potent and aggressive immunosuppressive action.
Tags: aspirin, Bezos, bioengineering,
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: This study evaluated the effects
of an antagonistic analog
of growth hormone - releasing hormone, MIA - 602, on
tumor growth, response to doxorubicin, expression
of drug resistance genes, and efflux pump function in
human triple negative
breast cancers.
Introduction: This study evaluated the effects
of an antagonistic analog
of growth hormone - releasing hormone, MIA - 602, on
tumor growth, response to doxorubicin, expression
of drug resistance genes, and efflux pump function in
human triple negative
breast cancers.
Dr. Mack's research has focused primarily on the use
of novel antitumor agents in
human estrogen receptor negative
breast tumor cells, and more recently, on the use
of bioflavonoids in the regulation
of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB-
breast tumor cell proliferation.
These kind
of mice are an extraordinary resource for modeling
human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a
human breast cancer gene) behave more similarly to
human cancer patients than those mice who have had a
tumor physically transplanted in.
Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations
of aluminum in the amount
of those measured in the
human breast are able to transform cultured mammary epithelial cells, allowing them to form
tumors and to metastasize.
And we confirmed that the growth
of the
tumors formed by the
human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those
of the control
tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation
of APC and the Wnt signaling is at least one
of the important pathways targeted by miR - 142 in
human breast cancer cells and BCSCs.
Considering that miR - 142 is highly expressed in
human BCSCs, but weakly expressed or undetectable in the stem / progenitor population
of the mammary epithelial cells, our result suggest that the upregulation
of miR - 142 and its enhancement
of the miR - 150 expression seem to be especially relevant in the
breast tumor progression in vivo.
The most frequent
tumors in
human — cancer
of the colon,
breast, lung, and prostate — all involve mutations in
tumor suppressor genes.
Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative
breast cancer — so called because
tumor cells in this particularly aggressive form
of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and
human epidermal growth factor receptor 2 (HER - 2).
«We not only uncovered the biological pathway stimulating cancer growth, but we found a compound that blocked it, increasing the survival
of mice carrying
human metaplastic
breast tumors,» Chang says.
We know that the lemony aura
of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against
breast tumors, 10 we have a ways to go before we can make such bold claims in
humans.
Studies
of Gluts in
human tumors have shown a significant increase in the abundance
of Glut1 and Glut3 mRNA in cancers
of the esophagus, colon, and pancreas, overexpression
of Glut1 and Glut3 mRNA and Glut1 protein expression in head and neck
tumors and Glut1 protein overexpression in
breast and renal cell carcinomas
As a result,
breast cancer cell growth is blocked One study in mice concluded that flaxseed inhibited the growth
of human estrogen - dependent
breast cancer, and strengthened the
tumor - inhibitory effect
of tamoxifen.
According to another study on mice, the
human equivalent
of just two handfuls
of walnuts a day cut
breast cancer risk in half, and slowed
tumor growth by 50 percent as well.
According to Lise Alschuler, author
of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against
breast cancer, «inhibiting the growth
of human estrogen - dependent
breast cancer cells in mice and strengthening the
tumor - inhibitory effect
of tamoxifen».
They help block the ability
of cancer cells to produce the
tumor invasion enzyme in the first place, in both
human colon cancer cells, and
human breast cancer.
Phytates have been shown to inhibit the growth
of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative
breast cancer cells, voicebox cancer, cervical cancer, prostate cancer, liver
tumors, pancreatic, melanoma, and muscle cancers.
Veterinary oncologists working with a program at the University
of Pennsylvania are treating mammary
tumors in shelter dogs with the hope
of learning about the progression
of breast cancer in
humans.