Sentences with phrase «of human pancreatic cancer»

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

Then, using Mayo Clinic's large panel of human pancreatic cancer biopsies, the scientists found that expression levels of Rac1b were significantly associated with the cancer's prognosis.

This image shows autophagic vesicles containing mutant K - Ras formed in the membrane of human pancreatic cancer cells after exposure to neratinib.

In the current study, Dr. Xu and colleagues gave radiation therapy to a mouse model of human pancreatic cancer to eradicate the bulk tumors, while only the cancer stem cells remained in the residual scars.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

Not exact matches

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.

The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret's lab, builds on a first - of - its - kind human - cell model of pancreatic cancer progression the lab described in 2013.

During lab testing, the compound «markedly inhibited» the growth of three human pancreatic cancer cell lines five days after treatment and induced the death of pancreatic cancer cells.

One of those genes, K - Ras, which was discovered nearly 30 years ago, is mutated in 30 percent of human tumors, including 90 percent of pancreatic cancers, 40 percent of colon cancers, and 20 percent of non-small cell lung cancers.

The study, conducted in mice and including analyses of human cancers, found very high levels of two proteins — dectin - 1 and galectin - 9 — in pancreatic tumors.

In a second group of experiments using human tissue from patients with pancreatic ductal adenocarcinoma, which accounts for more than 90 percent of pancreatic cancers, Zheng and his colleagues also tracked down a link between the abundance of Sema3D in those tissues and the progression of metastatic pancreatic cancer.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Pancreatic cancer is one of the most aggressive human cancers — symptoms do not occur until the cancer is well advanced.

This image shows an expression of the stem cell gene Musashi in human pancreatic cancer.

In humans, pancreatic cancer has the worst survival rate of any major cancer.

Cancer of the pancreas (scientifically known as pancreatic ductal adenocarcinoma or PaCa) is one of the most deadly forms of the disease in humans.

Research from Rutgers Cancer Institute of New Jersey shows that the «first in human» series of vaccine injections given directly into a pancreatic cancer tumor is not only well tolerated, but also suggests an «encouraging» period of stable diCancer Institute of New Jersey shows that the «first in human» series of vaccine injections given directly into a pancreatic cancer tumor is not only well tolerated, but also suggests an «encouraging» period of stable dicancer tumor is not only well tolerated, but also suggests an «encouraging» period of stable disease.

«Based on this research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.

The Carboxyl Tail of Connexin32 Regulates Gap Junction Assembly in Human Prostate and Pancreatic Cancer Cells.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

Since human pancreatic cancer has certain immunological characteristics of the mouse model, a phase 1 clinical trial of AMD3100 in patients with pancreatic cancer will be initiated in 2015.

Published in Human Molecular Genetics Ghiorzo P, Gargiulo S, Pastorino L, Nasti S, Cusano R, Bruno W, Gliori S, Sertoli MR, Burroni A, Savarino V, Gensini F, Sestini R, Queirolo P, Goldstein AM, Scarrà GB.Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma Hum Mol Genet.

The map evaluated mutations in virtually all known human protein - encoding genes, comprised of more than 20,000 genes, in 24 pancreatic cancers and 22 brain cancers.

Powerful inhibition of experimental human pancreatic cancers by receptor targeted cytotoxic LH - RH analog AEZS - 108.

Pancreatic enzymes are a natural part of the human body, which are limited in cancer patients.

Studies in humans have shown that lycopene is protective against a variety of cancers including prostate of course, but also colorectal, breast, lung, endometrial, pancreatic, bladder, cervical and skin cancers.

There is INSUFFICIENT EVIDENCE [1,4,5] about the effectiveness of lycopene supplements in the prevention or treatment of age - related macular degeneration (AMD), asthma, atherosclerosis, benign prostate hyperplasia, cancer (brain, breast, cervical, lung, ovarian, pancreatic, prostate), cataracts, coronary heart disease, diabetes type 2, gingivitis, high blood pressure, hot flashes in menopausal women, human papilloma virus (HPV) infection, inflammation, infertility, kidney disease, mouth sores (oral leukoplakia), or as an anticoagulant (blood thinner) or antioxidant or as sun protection.

The fact that this ongoing rise in pancreatic cancer has occurred along with a rise in human consumption of soybeans does not prove cause and effect.

Phytates have been shown to inhibit the growth of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative breast cancer cells, voicebox cancer, cervical cancer, prostate cancer, liver tumors, pancreatic, melanoma, and muscle cancers.