Variations include The Good, the Bad and the Whole Grain (Asia Pac J Clin Nutr, 17: 16 - 19) and The Good, the Bad, and the Cell Type - Specific Roles
of Hypoxia Inducible Factor - 1 in Neurons and Astrocytes (The Journal of Neuroscience, 28:1988 - 1993).
A focused oligonucleotide microarray of 1,178 genes, qRT — PCR of selected transcripts, and western analysis
of hypoxia inducible factor - 1α (HIF - 1α) were used to compare retinas from the hypoxic and recovery groups to control animals that were not made hypoxic.
Zuzana Kirsnerova (Baretton, TUD)-- «The role
of Hypoxia Inducible Factors in physiological and pathological angiogenesis» (2006)
Not exact matches
(
hypoxia inducible factor 1 alpha), a protein that acts as a sensor for oxygen and nutrients in many types
of cancer.
Hypoxia -
inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression
of various genes for glucose metabolism under conditions
of low oxygen levels, is the most well documented substrate
of the von Hippel - Lindau (VHL) enzyme.
To enable them to survive, adapt and grow in the low - oxygen or «hypoxic» environments, tumors contain increased levels
of a protein called
Hypoxia -
inducible factor 1 (HIF - 1).
When blood flow and oxygen levels are low, a transcription
factor called
hypoxia -
inducible factor (HIF) triggers the production
of a chemical called VEGF.
Key aspects
of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation
of the O2 - sensing HIF (
hypoxia -
inducible factor) hydroxylase EGL - 9.
Recent studies showed that low oxygen conditions increase levels
of a family
of proteins known as HIFs, or
hypoxia -
inducible factors, that turn on hundreds
of genes, including one called NANOG that instructs cells to become stem cells.
In a series
of cell - based studies, they showed that it both blocked a family
of iron - containing, oxygen - sensing enzymes called
hypoxia -
inducible factor prolyl - hydroxylases (HIF - PHD) and, critically, protected neurons by activating genes that protect them from oxidative stress.
Rastinejad's team then compared the new structures to those
of four other bHLH - PAS proteins, including two they previously solved,
hypoxia -
inducible factors (HIFs) 1α and 2α.
Evolution In recent years, athletes including cyclists have used drugs called HIF stabilizers (
hypoxia inducible factor), an emerging class
of kidney - disease drugs that stimulate the body's own production
of EPO by activating genes to express EPO.
Similarly, Bernaudin et al. [43] found increased expression
of 18 genes in the neonatal rat brain following
hypoxia (8 % O2 for 3 h) including several known
hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription
factors.
Hypoxia is also implicated in glaucoma by the finding of elevated hypoxia - inducible fact
Hypoxia is also implicated in glaucoma by the finding
of elevated
hypoxia - inducible fact
hypoxia -
inducible factor [9].
GCSF and
hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration
of CXCR4 expressing cells towards cardiac tissues [47 - 49].
Loss
of epithelial
hypoxia -
inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.
Activation
of hypoxia -
inducible factors in hyperoxia through prolyl 4 - hydroxylase blockade in cells and explants
of primate lung.
The interaction
of superoxide with nitric oxide destabilizes
hypoxia -
inducible factor - 1α.
Hypoxia -
inducible factors as key regulators
of tumor inflammation.
Publication: A novel injectable BRET - based in vivo imaging probe for detecting the activity
of hypoxia -
inducible factor regulated by the ubiquitin - proteasome system.
The supernatant
of apoptotic cells causes transcriptional activation
of hypoxia -
inducible factor — 1α in macrophages via sphingosine -1-phosphate and transforming growth
factor - β.
Expression
of angiopoietin - 1 in hypoxic pericytes: regulation by
hypoxia -
inducible factor - 2alpha and participation in endothelial cell migration and tube formation.
Direct Transcriptional Up - regulation
of Cyclooxygenase - 2 by
Hypoxia -
Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during
Hypoxia
He is best known for his ground - breaking discovery
of the HIF - 1 (
hypoxia -
inducible factor 1) protein, which controls genes in response to changes in oxygen availability.
A major aspect
of this process is the production
of multiple angiogenic cytokines and growth
factors in response to
hypoxia / ischemia, which is mediated by the transcription
factor HIF - 1 (
hypoxia -
inducible factor 1).
Tzouvelekis A, Harokopos V, Paparountas T, Oikonomou N, Chatziioannou A, Vilaras G, Tsiambas E, Karameris A, Bouros D and Aidinis V., 2007, «Comparative expression profiling in pulmonary fibrosis suggests a role
of hypoxia -
inducible factor - 1alpha in disease pathogenesis», Am J Respir Crit Care Med, 176 (11): 1108 - 19 [Pubmed]
«Comparative expression profiling in pulmonary fibrosis suggests a role
of hypoxia -
inducible factor - 1alpha in disease pathogenesis»
Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF,
hypoxia -
inducible factor; IFNγ, interferon γ; IKK, inhibitor
of nuclear
factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target
of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear
factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator
of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis
factor α; UPR, unfolded protein response; WAT, white adipose tissue
We showed that a chronic oxidative stress accelerates aging through accumulation
of HIF (
Hypoxia -
Inducible Factor) and modulation
of insulin signaling (Gerald, Cell, 2004; Laurent, Cell Metabolism, 2008).
Hypoxia Inducible Factor - 1α in Astrocytes and / or Myeloid Cells Is Not Required for the Development
of Autoimmune Demyelinating Disease
He did a post-doc in the lab
of Professor Chris Schofield working on the
Hypoxia -
inducible -
factor hydroxylase Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanic
factor hydroxylase
Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanic
Factor - Inhibiting - HIF and enzymes involved in biosynthesis
of clavulanic acid.
Interestingly, RIPK2 inhibitor 1 can also inhibit the activation
of hypoxia - response element I response to chemical induction using 1 % H2O2 (Supplemental Fig. 3C) to suggest either a link to inflammation or a direct modulation
of hypoxia -
inducible factor α function.
Expression
of hypoxia -
inducible factor - 1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related
Hypoxic activation
of unoccupied estrogen - receptor - alpha is mediated by
hypoxia -
inducible factor - 1 alpha
Endogenous markers
of two separate
hypoxia response pathways (
hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
Mouse fetal development is perturbed by culture in low oxygen concentration that increases expression
of oxygen - sensitive genes via
hypoxia inducible factors: A non-epigenetic embryonic programming phenomenon?