Sentences with phrase «of hypoxia inducible factors»

Zuzana Kirsnerova (Baretton, TUD)-- «The role of Hypoxia Inducible Factors in physiological and pathological angiogenesis» (2006)

A focused oligonucleotide microarray of 1,178 genes, qRT — PCR of selected transcripts, and western analysis of hypoxia inducible factor - 1α (HIF - 1α) were used to compare retinas from the hypoxic and recovery groups to control animals that were not made hypoxic.

Variations include The Good, the Bad and the Whole Grain (Asia Pac J Clin Nutr, 17: 16 - 19) and The Good, the Bad, and the Cell Type - Specific Roles of Hypoxia Inducible Factor - 1 in Neurons and Astrocytes (The Journal of Neuroscience, 28:1988 - 1993).

Not exact matches

(hypoxia inducible factor 1 alpha), a protein that acts as a sensor for oxygen and nutrients in many types of cancer.

Hypoxia - inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression of various genes for glucose metabolism under conditions of low oxygen levels, is the most well documented substrate of the von Hippel - Lindau (VHL) enzyme.

To enable them to survive, adapt and grow in the low - oxygen or «hypoxic» environments, tumors contain increased levels of a protein called Hypoxia - inducible factor 1 (HIF - 1).

When blood flow and oxygen levels are low, a transcription factor called hypoxia - inducible factor (HIF) triggers the production of a chemical called VEGF.

Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.

Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.

In a series of cell - based studies, they showed that it both blocked a family of iron - containing, oxygen - sensing enzymes called hypoxia - inducible factor prolyl - hydroxylases (HIF - PHD) and, critically, protected neurons by activating genes that protect them from oxidative stress.

Rastinejad's team then compared the new structures to those of four other bHLH - PAS proteins, including two they previously solved, hypoxia - inducible factors (HIFs) 1α and 2α.

Evolution In recent years, athletes including cyclists have used drugs called HIF stabilizers (hypoxia inducible factor), an emerging class of kidney - disease drugs that stimulate the body's own production of EPO by activating genes to express EPO.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Hypoxia is also implicated in glaucoma by the finding of elevated hypoxia - inducible factHypoxia is also implicated in glaucoma by the finding of elevated hypoxia - inducible facthypoxia - inducible factor [9].

GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].

Loss of epithelial hypoxia - inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.

Activation of hypoxia - inducible factors in hyperoxia through prolyl 4 - hydroxylase blockade in cells and explants of primate lung.

The interaction of superoxide with nitric oxide destabilizes hypoxia - inducible factor - 1α.

Hypoxia - inducible factors as key regulators of tumor inflammation.

Publication: A novel injectable BRET - based in vivo imaging probe for detecting the activity of hypoxia - inducible factor regulated by the ubiquitin - proteasome system.

The supernatant of apoptotic cells causes transcriptional activation of hypoxia - inducible factor — 1α in macrophages via sphingosine -1-phosphate and transforming growth factor - β.

Expression of angiopoietin - 1 in hypoxic pericytes: regulation by hypoxia - inducible factor - 2alpha and participation in endothelial cell migration and tube formation.

Direct Transcriptional Up - regulation of Cyclooxygenase - 2 by Hypoxia - Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during Hypoxia

He is best known for his ground - breaking discovery of the HIF - 1 (hypoxia - inducible factor 1) protein, which controls genes in response to changes in oxygen availability.

A major aspect of this process is the production of multiple angiogenic cytokines and growth factors in response to hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (hypoxia - inducible factor 1).

Tzouvelekis A, Harokopos V, Paparountas T, Oikonomou N, Chatziioannou A, Vilaras G, Tsiambas E, Karameris A, Bouros D and Aidinis V., 2007, «Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia - inducible factor - 1alpha in disease pathogenesis», Am J Respir Crit Care Med, 176 (11): 1108 - 19 [Pubmed]

«Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia - inducible factor - 1alpha in disease pathogenesis»

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

We showed that a chronic oxidative stress accelerates aging through accumulation of HIF (Hypoxia - Inducible Factor) and modulation of insulin signaling (Gerald, Cell, 2004; Laurent, Cell Metabolism, 2008).

Hypoxia Inducible Factor - 1α in Astrocytes and / or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease

He did a post-doc in the lab of Professor Chris Schofield working on the Hypoxia - inducible - factor hydroxylase Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanicfactor hydroxylase Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanicFactor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanic acid.

Interestingly, RIPK2 inhibitor 1 can also inhibit the activation of hypoxia - response element I response to chemical induction using 1 % H2O2 (Supplemental Fig. 3C) to suggest either a link to inflammation or a direct modulation of hypoxia - inducible factor α function.

Expression of hypoxia - inducible factor - 1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related

Hypoxic activation of unoccupied estrogen - receptor - alpha is mediated by hypoxia - inducible factor - 1 alpha

Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial

Mouse fetal development is perturbed by culture in low oxygen concentration that increases expression of oxygen - sensitive genes via hypoxia inducible factors: A non-epigenetic embryonic programming phenomenon?