James Allison, professor of immunology and chair of the Department of Immunology, The University of Texas MD Anderson Cancer Center Lieping Chen, United Technologies Corporation Professor in Cancer Research and professor
of immunobiology, of dermatology and of medicine, Yale University Gordon Freeman, professor of medicine, Dana - Farber Cancer Institute, Harvard Medical School Tasuku Honjo, professor of immunology and genomic medicine, Kyoto University Arlene Sharpe, the George Fabyan Professor of Comparative Pathology, Harvard Medical School; senior scientist, department of pathology, Brigham and Women's Hospital
Dr. Lieping Chen currently serves as the United Technologies Corporation Professor in Cancer Research, Professor
of Immunobiology, Dermatology and Medical Oncology at Yale School of Medicine and co-Director of the Cancer Immunology Program of Yale Cancer Center in New Haven, CT..
Sterling Professor
of Immunobiology at Yale University.
The Chairman of the Scientific Council is Professor Thomas Boehm, Managing Director at the Max Planck Institute
of Immunobiology and Epigenetics in Freiburg, the Chair of the Board of Trustees is Professor Dr. Jochen Maas, Head of Research and Development and Member of the Management Board, Sanofi - Aventis Deutschland GmbH.
United Technologies Corporation professor in Cancer Research and professor
of immunobiology, of dermatology and of medicine, Yale University
We thank D.L. Court (National Cancer Institute) for plasmid pSIM18 for the generation of BAC - transgenic mice; J.G. Cyster (UC San Francisco) for Hy10 mice; E. Hobeika and M. Reth (Max Planck Institute
of Immunobiology and Epigenetics) for Mb1 - Cre mice; M. Nussenzweig (The Rockefeller University) for B1 - 8hi mice, anti-DEC205 — OVA and anti-DEC205 — CS; G.D. Victora (Whitehead Institute for Biomedical Research) for gene sets for the gene - set - enrichment analysis; O. Ohara, T. Watanabe and Y. Mochizuki for transcriptome analysis; W. Ise for discussions; M. Tochigi, C. Kawai, A. Arakawa and H. Masuda for technical assistance; P. Burrows for critical reading; and R. Brink for communicating unpublished results.
The first few weeks after the transplant are critical, especially when the organ donor is deceased, said Jordan Pober, the Bayer Professor of Translational Medicine and professor
of immunobiology, pathology, and dermatology at Yale.
Today, the Sterling Professor
of Immunobiology, and HHMI investigator, directs one of the top immunology programs in the country, as well as his own lab.
A discovery by Dr. Xian C. Li, the director
of the Immunobiology & Transplant Science Center at Houston Methodist Research Institute, and his colleagues could lead to better drugs to treat asthma (Credit: Houston Methodist Research Institute)
«In essence, OX40 activates the IL - 9 gene in T helper cells, leading to the overproduction of IL - 9 through a powerful molecular machinery of super-enhancers that regulate gene expression,» says Dr. Xian C. Li, the director
of the Immunobiology & Transplant Science Center at Houston Methodist Research Institute.
He holds a degree in biology from the Albert - Ludwigs - University and a Ph.D. from the Max Planck Institute
of Immunobiology, and has a strong record of innovative scientific contributions, including peer - reviewed publications, patents and research grants.
That first breakthrough continues to inform the work of Dr. Medzhitov, who is today the David W. Wallace Professor
of Immunobiology at Yale University Medical School, a member of Yale Cancer Center and the National Academy of Sciences, and an HHMI investigator.
A new study by researchers at the Max Planck Institute
of Immunobiology...
He was a member
of the immunobiology study section of the National Institutes of Health and of the Leukemia Research Foundation's advisory board.
Participating institutions: Helmholtz Association • CNRS • Institute of Molecular Biotechnology • Research Center for Molecular Medicine of the Austrian Academy of Sciences • VIB - KU Leuven • Friedrich Miescher Institute for Biomedical Research • University of Basel • University of Zurich • Central European Institute of Technology • Max Planck Institute
of Immunobiology and Epigenetics • Max Planck Institute for Molecular Genetics • German Cancer Research Center • Max Delbrück Center for Molecular Medicine • German Center for Neurodegenerative Diseases • Helmholtz Zentrum München • Max Planck Institute for Evolutionary Anthropology • Helmholtz Institute of RNA - based Infection Research • Saarland University • Technical University Munich • University of Würzburg • Biotech Research & Innovation Centre • Interdisciplinary Nanoscience Center • University of Copenhagen • Centre for Genomic Regulation • Institut Curie • Université de Montpellier • Inserm • Université Toulouse III — Paul Sabatier • École nationale supérieure des mines de Paris • Institute for Molecular Medicine Finland • The Biomedical Research Foundation, Academy of Athens • Weizmann Institute of Science • Hebrew University • Sapienza — University of Rome • Instituto Nazionale Genetica Molecolare • University of Napoli • University of Padua • University of Milan • European Institute of Oncology • Netherlands Cancer Institute • Radboud University • University Medical Center Utrecht • Hubrecht Institute • Instituto Gulbenkian de Ciência • Institute of Bioorganic Chemistry of the Polish Academy of Sciences • Romanian Center for Systems Immunology • Karolinska Institute • MRC Human Genetics Unit • University of Edinburgh • Wellcome Sanger Institute • The Babraham Institute • European Molecular Biology Laboratory — European Bioinformatics Institute
Lukas Flatz is currently senior consultant (OAmbF) at the Clinic for Dermatology and Group Leader at the Institute
of Immunobiology, Kantonsspital St.Gallen, St. Gallen, Switzerland.
The research team includes Dr. Masanori Miyata and Dr. Ji - Yun Lee at Georgia State; Dr. Richard A. Flavell, chair of the Department
of Immunobiology, investigator at the Howard Hughes Medical Institute and a member of the National Academy of Sciences at Yale University; Dr. Koichi S. Kobayashi, professor in the Department of Microbial Pathogenesis and Immunology at the Texas A&M Health Science Center; and Dr. Hirofumi Kai at Kumamoto University in Japan.
«Preventing the degradation of MBD3 protein will make it difficult for myeloma cells to escape this class of drugs,» said senior author Madhav Dhodapkar, professor
of immunobiology and chief of the Section of Hematology.
Dr. Nguyen is a research assistant professor in the Department of Neurology and a research scientist in the Department
of Immunobiology at the University of Arizona.
Dr. Doyle is an assistant professor in the Departments
of Immunobiology and Neurology at the University of Arizona.
He and his team at the Max Planck Institute
of Immunobiology and Epigenetics in Freiburg, Germany used fruit flies to explore how epigenetic modifications are transmitted from the mother to the embryo.
Now researchers from the Max Planck Institute
of Immunobiology and Epigenetics in Freiburg show robust evidence that not only the inherited DNA itself but also the inherited epigenetic instructions contribute in regulating gene expression in the offspring.
«We were surprised at how profound the effects of feeding were, both positive and negative,» says senior author Ruslan Medzhitov, David W. Wallace Professor
of Immunobiology and a Howard Hughes Medical Institute investigator at Yale School of Medicine.
«A handful of bad bacteria are able to attain access to the immune system and get right at the gut,» said Richard Flavell, the Sterling Professor
of Immunobiology at the Yale School of Medicine.
To explore these questions Akiko Iwasaki, professor
of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.
The research team, led by Akiko Iwasaki, professor
of immunobiology and Howard Hughes Medical Institute investigator, decided to investigate using mice models of herpes simplex virus - 1, the dominant cause of genital herpes in the United States.
Department of Cell Biology and Section
of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 — 8002, USA.
«This gut microbiota has been linked to the inflammation that triggers obesity, diabetes, metabolic disease, and most of chronic health problems of the Western World,» said Yale's Richard Flavell, Sterling Professor
of Immunobiology, Howard Hughes Medical Institute investigator, and co-senior author of the paper appearing Feb. 27 in the journal Cell.
Sankar Ghosh, professor
of immunobiology at Yale University, explores the regulation of gene expression in developing and differentiating lymphocytes.
Caetano Reis e Sousa, head
of the immunobiology lab at Cancer Research UK's London Research Institute, sounds says the work is «exciting» but cautions that it is at an early stage.
Kristian Doyle, assistant professor
of immunobiology and neurology at the University of Arizona College of Medicine in Tucson, uses biomarkers to study how the immune system deals with dead brain tissue after a stroke.
Not exact matches
Take Kellie Ann Jurado, a postdoctoral scientist in
immunobiology at Yale University, who will use the funding for research on the effects
of the Zika virus on the nervous system.
Trained as a psychobiologist, his research has contributed to advancements in the fields
of developmental psychology, physiological psychology, and perception; he has also made important contributions in the fields
of genetics, developmental biology,
immunobiology, ethology, and molecular biology.
The project was led by three scientists: John Harley, MD, PhD, Director
of the Center for Autoimmune Genomics and Etiology (CAGE) at Cincinnati Children's and a faculty member
of the Cincinnati VA Medical Center; Leah Kottyan, PhD, an
immunobiology expert with CAGE; and Matthew Weirauch, PhD, a computational biologist with the center.
Department
of Microbiology and
Immunobiology, Division
of Immunology, Harvard Medical School, Boston, MA 02115, USA.
«By switching certain genes on and off, prions could help bacteria survive environmental stresses rendering them less vulnerable to drugs, chemicals and other environmental assaults,» says investigator Ann Hochschild, professor
of microbiology and
immunobiology at HMS.
Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor
of Medicine and
Immunobiology, and chief
of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation
of the immune system by lipids made in the context
of inflammation underlies the origins
of at least a third
of all myeloma cases.
«This was an example
of true crosspollination expertise and knowledge,» said Mathis, a professor
of microbiology and
immunobiology at HMS.
«Because we observed microbial effects mainly in the gut, we believe that a microbe - based therapy would avoid the collateral damage seen with drugs that wipe out classes
of immune cells across the body,» said Benoist, a professor
of microbiology and
immunobiology at HMS.
«We set out to map out interactions between bacteria and the immune system in the hope that this could eventually lead to the development
of an apothecary
of agents tailored to modulate the immune system selectively and precisely,» said senior investigator Dennis Kasper, professor
of medicine and microbiology and
immunobiology at HMS.
«The paper provides a dazzling snapshot
of the process
of transcription activation — the process whereby a gene is turned on in response to an instructive signal from the environment,» said Ann Hochschild, professor
of microbiology and
immunobiology at Harvard Medical School, who also was not part
of the study.
Scientists understand reasonably well how this autoimmune attack progresses, but they don't understand what triggers the attack or how to stop it, says Stephan Kissler, Ph.D., Investigator in the Section on
Immunobiology at Joslin Diabetes Center and Assistant Professor
of Medicine at Harvard Medical School.
The work «confirms once again that very likely all mammals can be cloned once the reproductive biology and physiology
of the particular species is understood and taken into account,» says developmental biologist Davor Solter
of the Max Planck Institute for
Immunobiology in Freiburg, Germany.
Channing Laboratory, Brigham and Women's Hospital and Department
of Microbiology and
Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Ruiz co-led the study with Thomas Bernhardt, associate professor
of microbiology and
immunobiology at Harvard Medical School.
Christophe Benoist, M.D., professor
of Microbiology and
Immunobiology at Harvard Medical School, (who spoke on behalf
of Diane Mathis, Ph.D., also a professor in the same department) discussed a molecule called I - BET that, when used as a treatment in animals during pre-diabetes or in the early stages
of clinical type 1 diabetes, seemed to slow the progression
of the disease.
Prof. Mike Turner, Director
of Science and Head
of Infection and
Immunobiology, the Wellcome Trust, said:
The second laboratory continues to focus attention on transplantation
immunobiology in mouse models and translational studies
of human immunology in transplant recipients.
Immunobiology and pathogenesis
of viral hepatitis.
Funding Research reported in this news release was supported by the National Institute
of Diabetes and Digestive and Kidney Diseases
of the National Institutes
of Health under award number R56DK106202 - 01, the Cedars - Sinai Board
of Governors Regenerative Medicine Institute, the Cedars - Sinai F. Widjaja Foundation Inflammatory Bowel and
Immunobiology Research Institute and the Drown Foundation.