Sentences with phrase «of immunogens»

A Genome - Wide Proteome Array Reveals a Limited Set of Immunogens in Natural Infections of Humans and White - Footed Mice with Borrelia burgdorferi

Dr. Schief's work focuses on computation - guided and structure - based design of immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and other pathogens that have frustrated traditional vaccine design strategies.

Not exact matches

«Then the ultimate proof of utility of this discovery is to use it to design immunogens that can induce broadly neutralizing antibodies by vaccination.»

Immunogens are designed to elicit the production of highly coveted broadly neutralizing antibodies that protect against HIV - 1 [Also see Report by McGuire et al..]

«We'd like to synthesize vaccine immunogens [proteins that trigger antibody production] that can elicit the same types of broadly protective antibodies in people,» says Dr. Chandran.

A major goal of HIV - 1 vaccine development is to identify immunogens capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating, neutralization - resistant (tier 2) viruses.

Thus, our findings indicate that native - like trimers represent a promising starting point for the further development of recombinant Env immunogens intended to broaden the NAb response.

This suggests the immunogens imposed constraints resulting in a common structural mode of high affinity encoded by different sequences.

Paradoxically, it remains the case that even minimal mutation towards the J3 germ line V gene abolishes the ability to bind either immunogen used [26]; the reintroduction of the three germ line CDR2 residues renders the VHH incapable of binding Env.

This difference in binding ability to the two immunogens suggests the R2 immunogen may have driven the earlier stages of affinity maturation of this lineage in llama 1, which resulted in clones that could also recognize 96ZM651.02 gp140 as the immune response progressed and the lineage developed breadth via mutations in the V gene region.

A critical implication of this work for the field of HIV vaccine design is the observation that the most potent and broad individual anti-HIV VHH, J3, was elicited in response to the gp140 immunogens used.

For the published request for applications, see the May 18, 2016 Guide announcement, Partnerships for Structure - Based Design of Novel Immunogens for Vaccine Development (R01).

Antibodies against the immunogen can then be purified from the serum of the animal.

The first immunogens are those similar to the trimer outer Envelope protein of native HIV.

The other is a so - called «germline - targetting» immunogen that is engineered to induce the earliest precursors of a specific class of bNAbs.

Working backward, they lab - engineered an Env mimic, called an immunogen, capable of kick - starting the immune response that eventually produces bnAbs.

A team of scientists led by NAC and IAVI researchers have already engineered a prototype immunogen — the active ingredient of a vaccine — based on insights gleaned from such studies.