Sentences with phrase «of infection models»

In an international cooperation with Italian and Austrian partners, an American research group and German experts from Erlangen, Bochum and Kiel, Ulrike Sauermann and Christiane Stahl - Hennig, scientists from the Unit of Infection Models at the German Primate Center, have tested a vaccination approach that takes these critical factors into account.

Infection researcher Dr. Ahmed Abd El Wahed and the head of the Unit of Infection Models at the German Primate Center (DPZ), Dr. med.

Dr. Ahmed Abd El Wahed, scientist in the Unit of Infection Models at the DPZ, is the innovator of the suitcase laboratory.

«The early detection of Ebola infected patients will lead to a more effective virus control since medical staff can identify and isolate confirmed Ebola cases more rapidly,» said Dr. Christiane Stahl - Hennig, the Head of the Unit of Infection Models.

Not exact matches

This myth is based in some truth — one of the first IUD models, called the Dalkon Shield, was linked to infections that can cause infertility — but it's not pertinent to IUDs that one might get today.

When the scientists modeled disease transmission, they found that while an «infected person's 11 nearest neighbors faced a greater than 80 percent chance of infection,» Wired reports, «all the remaining passengers, however, had a lower than 3 percent risk.»

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

For example, in one activity called «Stem of the Living Dead,» students explore the exponential growth of a zombie hoard and how the spread of the infection creates limited resources using World Health Organization and CDC models and graphs.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

Variables were retained in the reduced logistic regression model when their presence was determined to confound the association between human milk feeding and infection or sepsis / meningitis, as defined by a change of > 5 % in the regression coefficient for type of feeding when the variable was removed from the full regression model.

Hospital, doctor, or clinic visits or hospital admissions as a result of any respiratory infection or illness were combined as composite variables reflecting any respiratory morbidity, and the protective effect of breast feeding persisted in all models (p < 0.01).

The resulting inoculation looks promising in both ferrets and mice, the most commonly used models of influenza infection.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Infections of other poxviruses in their natural hosts provide more realistic, yet still imperfect, models.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

«We found that the syncytiotrophoblasts formed in our system recapitulated the barrier properties of the naturally occurring cells and they resisted infection by a model virus and three genetically different strains of Toxoplasma,» said co-investigator Jon P. Boyle, Ph.D., associate professor of biological sciences at Pitt.

Virgin and his team decided to explore this possibility by studying a mouse model of chronic norovirus infection.

By using this model, they showed for the first time that Pseudomonas aeruginosa colonised the nasopharynx — the part of the body which connects the back of the nose to the back of the mouth — long term and then subsequently migrated down into the lungs to cause chronic infection.

The researchers next established that 25HC is protective in mouse and monkey models of Zika virus infection.

In the study, which included a series of laboratory experiments, field surveys and mathematical modeling, the presence of various species of dragonfly larvae reduced the infections in frogs caused by parasitic flatworms called trematodes, said Val Beasley, professor and head of the department of veterinary and biomedical sciences, Penn State, who worked with Rohr and whose research group collaborated with Lucinda Johnson, senior research associate and director of the Center for Water and the Environment, University of Minnesota Duluth, to complete the field study.

In order to project the impact of proposed cutbacks to U.S. - funded programs in South Africa, which has the greatest prevalence of HIV infection of any country, and the west African nation of Côte d'Ivoire, which has a different kind of epidemic and a different level of foreign aid dependency, the researchers used a widely - published mathematical model along with epidemiologic and cost data from each country to project the outcomes of potential programmatic responses.

Based on these read - outs, they developed prediction models for the analysis of mosquitoes with unknown infection status.

«We developed models explaining the occurrence of the multiple peaks and tested border control strategies to determine if a strict border control in the United States could reduce the total number of infections.»

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

The mouse model should also be useful for studying the immunological reactions and viral clearance in hepatitis B virus infection, they note in the Journal of Virology.

Spencer Fox, co-lead author and PhD Student at the University of Texas at Austin, said: «Our model was designed to quantify the risk of local Zika outbreaks as cases accumulate across Texas, taking into account international travel patterns, mosquito habitat, and the low detection rate of Zika infections.

«What was really remarkable was that all of the models showed that strong border control would not have decreased the total number of infections,» said Dr. Howie Weiss, professor in Georgia Tech's School of Mathematics or College of Sciences.

Four of the models indicated that if that stricter border control is related to fewer waves of infection.

The program is multidimensional, from cutting - edge mathematical virus modeling to field educators teaching hunters how to reduce risk of infection from contaminated game.

The scientists in Rodewald's department, working together with Thomas Höfer, now also plan to use the new model to investigate the impact of pathogenic challenges to blood formation: for example, in cancer, cachexia or infection.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Taking a cue from AIDS researchers, who use simian immunodeficiency virus in monkeys as a model for HIV infection, Fred Wang of Brigham and Women's Hospital and Harvard Medical School in Boston set out to find a primate version of EBV.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

Working with a mouse - model of parainfluenza virus infection, Sendai virus, which causes similar symptoms and patterns of tissue damage to RSV, researchers found that mice fared much worse in fighting the infection when their cells lacked IL - 27 signaling.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

This is the first large - scale model of TB in cattle and badgers that included the possibility of the infection being passed in both directions between the two species.

If we can provide a window for antibiotics to carry out their intended function, we can move towards a clinical model and ultimately cure joint infection,» offered Sana Dastgheyb, Ph.D., lead author on this study and researcher at both Thomas Jefferson University and the National Institutes of Health.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

Ultimately, the team wanted to build a model that could use a mouse's starting gut bacterial community to predict that mouse's risk of infection.

Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose lab is adept at using mouse models of C. difficile infection.

A daily pill to prevent HIV infection can reduce new cases among men who have sex with men (MSM) by a third in the U.S. over the next 10 years, according to a new modeling study published in The Journal of Infectious Diseases and available online.

In this study, researchers at Emory University, CDC, and the University of Washington used network - based mathematical models of HIV transmission in a population of MSM to estimate the impact of applying these CDC guidelines to prevent new HIV infections in the U.S..

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

Efforts to combat the rapid spread of Zika virus got a boost this week as researchers at the University of Texas Medical Branch, Galveston (UTMB) announced the first peer - reviewed publication of a mouse model for Zika infection reported in decades.

The National Institutes of Health had agreed to fund the study, which involved creating an animal model of anthrax infection in baboons, and the university's animal use and care committee had given it the green light.

«New mouse model to aid testing of Zika vaccine, therapeutics: Model mimics aspects of infection in people.&rmodel to aid testing of Zika vaccine, therapeutics: Model mimics aspects of infection in people.&rModel mimics aspects of infection in people.»

He had no animal model of the infection to use in his studies — rats and mice are not susceptible — so he famously used an experimental subject that did not require ethics approval or special funding: himself.

The abscesses contained Gram - negative bacteria, and when similar bacterial infections were deliberately induced in the CCM model animals, about half of them developed significant CCMs.

«Given the key similarities to human infections, a marmoset model of Zika may be useful for testing of new drug and vaccines,» said Texas Biomedical Research Institute virologist Jean Patterson, Ph.D. «Having an animal model of Zika infection to study may help us identify places where we might be able to block transmission.»