If the other gene were located on the part of the circle that was copied last, the ratio
of KinA to Spo0F would be one - to - one only when DNA replication was nearly completed.
Furthermore, these spikes were timed based upon the positions
of the KinA and Spo0F genes on the bacterial genome.
Because replication of circular bacterial DNA always initiates at one particular point, Narula surmised that the location
of the KinA and Spo0F genes could be crucial.
«The inhibition
of KinA by 0F results in a «negative feedback loop,» which means the circuit output works to counteract the input that triggers it,» said Narula, co-lead author of the study.
Not exact matches
so you look through the playbook and pick out little passages out
of context that sorta -
kina - not - really justifies what you thought.
This illustration
of the replication cycle for circular bacterial DNA shows how Bacillus subtilis bacteria use the ratio
of proteins
KinA to Spo0F to time their decision to form spores.
In investigating how this spike occurred, Narula pored through dozens
of published studies and noticed a discrepancy between some experimental results and the widely accepted view
of the interactions between two key players in the sporulation network, a protein called Spo0F and a kinase called
KinA.
We brought in a little bit
of Ben's homeland with the
kina shells from New Zealand.