Dr. Shepherd has been recognized for her many contributions in the field
of lung cancer research.
asks Paul Bunn Jr., MD, FASCO, distinguished professor at the University of Colorado Cancer Center and James Dudley Professor
of Lung Cancer Research at the University of Colorado School of Medicine.
Not exact matches
Because
of lung cancer's reputation as a self - induced illness and its low survival rate, it rarely attracts big
research money.
She spoke at Genentech, a
cancer research firm, exchanged e-mails with half a dozen other
cancer patients nationwide and was interviewed on NPR as a voice
of nonsmoker
lung -
cancer sufferers.
This appeared to be confirmed by further
research in 1954, prompting the government to issue its first warning
of the link between
lung cancer and smoking.
Smoking in cars can expose children's
lungs to levels
of carcinogens and toxins at rates 10 times higher than when smoking was permitted in bars, added Dr. Mark Travers, a
research scientist in the Division
of Cancer Prevention and Population Sciences at Roswell.
«Our study suggests that epigenetic changes to cells treated with cigarette smoke sensitize airway cells to genetic mutations known to cause
lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for
Cancer Research and professor
of oncology at the Johns Hopkins Kimmel
Cancer Center.
Scientists from Moffitt reported in the Jan. 19 online edition
of Cancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arresti
Cancer Research that nicotine induces the metastatic spread
of lung cancer cells by stimulating a protein called beta - arresti
cancer cells by stimulating a protein called beta - arrestin - 1.
After 20 years
of research and almost as many years fighting industry groups in court for control
of their data, government scientists can finally publish two papers showing that underground miners exposed to diesel fumes have a threefold increased risk for contracting
lung cancer.
Delegates included those interested in all aspects
of lung cancer, including surgeons, medical oncologists, radiation oncologists, pulmonologists, radiologists, pathologists, epidemiologists, basic
research scientists, with special sessions for nurses, allied health professionals and advocacy members.
If hypofractionated radiation with curative intent can reduce the treatment time for
lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this
research could result in a change in the paradigm
of how a large subset
of locally advanced NSCLC patients are treated.»
The
research was published in the Jan. 18 issue
of Molecular Carcinogenesis, which focused on recent advances in
lung cancer.
While pursuing her project on how environmental contaminants and oxidative stress cause
lung cancer, Gelhaus complemented her postdoctoral training by spending some time with other PIs at Penn. «She has worked hard to develop skills that are independent
of those available in my own laboratory while working on a project that is central to my
research program,» Blair writes in an e-mail to Science Careers.
«We urgently need new treatments for
lung cancer patients, and this
research suggests we can boost the effectiveness
of an existing drug, rather than switch to another new expensive treatment.
The trial also recorded fewer cases
of lung cancer in those on the treatment, consistent with basic
research findings hinting that the same inflammatory pathway may initiate or spur tumor growth.
Until now, EGFR inhibitors have only been effective at treating the 10 to 15 percent
of non-small cell
lung cancers that have a variant
of EGFR, but the two - drug combo could potentially work for all non-small cell
lung cancers, explained Dr. John Minna, Director
of the Hamon Center for Therapeutic Oncology
Research and Professor
of Internal Medicine and Pharmacology.
Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases
of lung cancer in those on the treatment, rekindling basic
research findings hinting that the same inflammatory pathway may initiate or spur the growth
of such tumors.
The
research was funded by the National Heart,
Lung, and Blood Institute
of the National Institutes
of Health and the National
Cancer Institute.
A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling
cancer growth in patients with non-small cell
lung cancer (NSCLC), according to new
research from the Icahn School
of Medicine at Mount Sinai.
Italian
researches have demonstrated a better way
of determining the aggressiveness
of tumors in patients with advanced non-small cell
lung cancer (NSCLC).
Researchers at the Menzies Centre for Population Health
Research in Hobart have found that in Tasmania between 1983 and 1992, there were almost twice as many
lung cancer cases among women aged between 25 and 44 years as in men
of the same age.
Terry Dwyer, director
of the centre, says that more
research will be needed before the jump in
lung cancer in women under 45 can be blamed primarily on smoking.
New
research shows that microRNA - 486 is a potent tumor - suppressor molecule in
lung cancer, and that the it helps regulate the proliferation and migration
of lung -
cancer cells, and the induction
of programmed cell death, or apoptosis, in those cells.
Research from McMaster University has identified new regulators
of brain metastases in patients with
lung cancer.
«If you look at a set
of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hos
cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary
lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hos
cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School
of Medicine, scientist with the Stem Cell and
Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hos
Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.
The
research, presented at the European Respiratory Society (ERS) International Congress in Munich, suggests that testing the temperature
of breath could be a simple and noninvasive method to either confirm or reject the presence
of lung cancer.
The
research team accounted for the impact
of smoking among the participants, since people who smoke are more likely to get periodontal disease, and smoking raises the risk
of lung and colon
cancers.
Researchers from the University
of Portsmouth's Brain Tumour
Research Centre
of Excellence have identified molecules which are responsible for metastatic
lung cancer cells binding to blood vessels in the brain.
Seemingly healthy cells may in fact hide clues that
lung cancer will later develop, according to a study led by researchers at The University of Texas MD Anderson Cancer Center The research is published online in the Journal of the National Cancer Inst
cancer will later develop, according to a study led by researchers at The University
of Texas MD Anderson
Cancer Center The research is published online in the Journal of the National Cancer Inst
Cancer Center The
research is published online in the Journal
of the National
Cancer Inst
Cancer Institute.
What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role
of a population
of stem cells in
lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate
research programs.
To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor
of oncology at the Johns Hopkins University School
of Medicine; Kellie N. Smith, Ph.D., a
cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer immunology
research associate at the Johns Hopkins University School
of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for
Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
Cancer Immunotherapy studied tumors
of four patients with non-small cell
lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer and one patient with head and neck
cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.
Dr. Timmerman, who holds the Effie Marie Cain Distinguished Chair in
Cancer Therapy Research, has championed the use of SABR globally and has served as the lead investigator in several national trials designed to evaluate the efficacy and safety of SABR to treat cancer in the lung, liver, spine, and pro
Cancer Therapy
Research, has championed the use
of SABR globally and has served as the lead investigator in several national trials designed to evaluate the efficacy and safety
of SABR to treat
cancer in the lung, liver, spine, and pro
cancer in the
lung, liver, spine, and prostate.
A
lung cancer diagnosis appears to put patients at the greatest risk
of suicide when compared to the most common types
of non-skin
cancers, according to new
research presented at the ATS 2017 International Conference.
Scientists from the
Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small cell lung cancer
Cancer Research UK Manchester Institute, based at The University
of Manchester and part
of the Manchester
Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small cell lung cancer
Cancer Research Centre, teamed up with experts at AstraZeneca, as part
of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small cell
lung cancer cancer cells.
The treatment is promising enough that
research teams around the world are developing similar stem cell therapies that can target and eradicate
cancers of the prostate,
lung, breast, skin and other tissues.
The stem cells that proliferate the most in response to damage caused by cigarette smoke repair their DNA using a process prone to errors, setting the stage for
lung cancer, according to a study publishing January 26, 2017 in the open - access journal PLOS Biology by Marie - Liesse Asselin - Labat and her team
of the Walter and Eliza hall Institute
of Medical
Research, Australia.
The article, titled «Entinostat Neutralizes Myeloid Derived Suppressor Cells and Enhances the Antitumor Effect
of PD - 1 Inhibition in Murine Models
of Lung and Renal Cell Carcinoma,» was published in Clinical
Cancer Research and is available online.
The quest to improve survival
of children with a high - risk brain tumor has led St. Jude Children's
Research Hospital investigators to two drugs already used to treat adults with breast, pancreatic,
lung and other
cancers.
The
research suggests that the genetic seeds
of cancer can sit dormant in a person's
lungs for decades, providing hope that the disease could be detected early.
The study's findings, published in the journal
Cancer Research, are the first to use these combined agents as an immune stimulator and may have the potential to kill cancerous cells in solid tumors, including some
of the most aggressive
cancers that form in the
lung and pancreas.
«Advances in
lung cancer therapy require a greater understanding
of the molecular origins
of this deadly disease,» said last corresponding author Levantini, who is also a researcher at the Institute
of Biomedical Technologies at the Italian National
Research Council (ITB - CNR).
Recent
research has shown that
lung CT screening
of smokers with smoking histories
of at least 30 - pack years can lead to early detection
of lung cancer and reduce deaths by 20 percent.
Anil Potti, M.D., Duke University School
of Medicine: Based on the reports
of investigations conducted by Duke University School
of Medicine (Duke) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Anil Potti, former Associate Professor
of Medicine, Duke, engaged in
research misconduct in
research supported by National Heart,
Lung, and Blood Institute (NHLBI), National Institutes
of Health (NIH), grant R01 HL072208 and National
Cancer Institute (NCI), NIH, grants R01 CA136530, R01 CA131049, K12 CA100639, R01 CA106520, and U54 CA112952.
Researchers from the Perelman School
of Medicine at the University
of Pennsylvania, along with the Institute for Health
Research at Kaiser Permanente Colorado, Kaiser Permanente Hawaii, the Henry Ford Health System in Detroit, and Marshfield Clinic Health System in Wisconsin, have received a five - year, $ 15.5 million National
Cancer Institute (NCI) grant to improve lung cancer scre
Cancer Institute (NCI) grant to improve
lung cancer scre
cancer screening.
Funding: NIH's National Institute
of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Heart,
Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Center for Advancing Translational Sciences (NCATS), National
Cancer Institute (NCI), and National Human Genome
Research Institute (NHGRI); and many other funding entities (see reference paper for the full list).
When a 2004 study by other researchers showed that eating foods containing beta - cryptoxanthin (BCX)-- a red pigment abundant in sweet red peppers, paprika, winter and butternut squash, oranges, and tangerines, among other foods — was associated with a lower risk
of lung cancer in people who smoke, he made BCX a focus
of his
research.
The National Heart,
Lung and Blood Institute
of the U.S. Department
of Health and Human Services, the National
Cancer Institute and Wyeth - Ayerst
Research Laboratories funded the study, which involved researchers at nine institutions and 15 WHI clinical - study sites nationwide.
The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office
of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute
of Allergy and Infectious Diseases; the National Heart,
Lung and Blood Institute; the National Institute on Aging; the National Institute
of Alcohol Abuse and Alcoholism; the National Institute
of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute
of Child Health and Human Development; NIDCD; the National Institute
of Dental and Craniofacial
Research; the National Institute
of Environmental Health Sciences; the National Institute
of General Medical Sciences; the National Institute
of Mental Health; the National Institute
of Neurological Disorders and Stroke; the National Institute
of Diabetes and Digestive and Kidney Diseases; the National
Cancer Institute; and the Office
of AIDS
Research.
Commenting on the significance
of the
research, Dr Pilar Garrido, head
of the Thoracic Tumour Section
of the Medical Oncology Department at Ramón y Cajal University Hospital, Madrid, Spain, said: «
Lung cancer is the most common
cancer globally, but debate about the optimal screening strategy is ongoing and current selection criteria are based only on age and pack - years.
DENVER — A pre-competitive consortia
of pharmaceutical, diagnostic companies and academic associations, including the International Association for the Study
of Lung Cancer (IASLC), announced phase I results
of the «BLUEPRINT PD - L1 IHC ASSAY COMPARISON PROJECT» at the Annual Meeting
of the American Association for
Cancer Research (AACR) on April 19.