High doses
of Lysodren can be used to treat adrenal tumors, but the incidence of serious side effects can be much higher.
A maintenance dosing
of Lysodren is typically once or twice a week, and the drug is inexpensive.
Not exact matches
Since trilostane and
lysodren are virtually the only medications used for Cushing's disease, we will confine our discussion to the behavioral uses
of selegiline hydrochloride.
A new approach is to use
Lysodren at very high doses to totally destroy the adrenal tissue, leaving the patient permanently adrenal - insufficient and requiring regular supplementation
of cortisol and other adrenal hormones.
If this is not feasible for any reason, suppression
of the tumor with
Lysodren is sometimes effective.
It is useful for dogs that can not tolerate
Lysodren, has a low incidence
of toxicity, and is completely reversible if necessary.
The current treatment
of choice for pituitary - dependent Cushing's is chemotherapy with op - DDD (mitotane,
Lysodren ®).
Lysodren selectively kills the outer layer
of the adrenal gland that produces corticosteroids.
If calcinosis cutis is the problem it will be necessary to try to adjust the dosage
of mitotane (
Lysodren Rx) to better control the Cushing's disease or to consider switching to one
of the other treatments.
A: Some dogs do not respond to
Lysodren and it seems likely that your dog may be one
of them.
Mitotane (
Lysodren) and trilostane (Vetoryl) are oral medications that selectively destroy part
of the adrenal cortex so that although the pituitary gland tumor continues to release ACTH, cortisol levels remain normal.
Cortisol levels must be monitored closely during the induction phase
of treatment with
Lysodren.
Usually antidotal prednisone is prescribed to the patient in case
of a reaction to
Lysodren.
Lysodren is usually not effective for treatment
of Cushing's disease in cats.
With this disease there are a number
of prescription medications available, such as Vetoryl, Anipryl and
Lysodren.
However, the adrenal glands also produce a variety
of sex hormones and
Lysodren will lower or stop their production as well.