Type 1 Diabetes: Urinary Proteomics and Protein Network Analysis Support Perturbation
of Lysosomal Function.
Elizabeth B. Moloney, PhD, is a post-doctoral research fellow at the Neuroregeneration Research Institute at McLean Hospital, where she is involved in developing both in vitro and in vivo approaches for understanding the role
of lysosomal function in the pathophysiology of cellular aging and...
Not exact matches
That depression in turn weakened overall
lysosomal function and contributed to degeneration
of neurons.
The researchers found that degenerative changes and loss
of vision are caused by impaired
function of the
lysosomal clean - up mechanism, or autophagy, in the fundus
of the eye.
Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation
of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status
of their lysosomes, how lysosomes are affected during age - related disease states and whether
lysosomal function can be modulated for therapeutic purposes.
Both MPS IIIA and GM1 are classified as neuropathic (i.e. affecting the central nervous system)
Lysosomal Storage Disorders, a group of approximately 50 rare inherited metabolic disorders that result from defects in lysosomal
Lysosomal Storage Disorders, a group
of approximately 50 rare inherited metabolic disorders that result from defects in
lysosomal lysosomal function.
Another example
of a transceptor is SLC38A9, which mediates
lysosomal arginine signalling [14,15], but also has transport
function.
They suggest that the effects on lysosomes are secondary to reduced Aβ accumulation, but I suspect the causation may work in the reverse direction, since they found that HBCD lowered cellular membrane cholesterol, and abnormally high
lysosomal membrane cholesterol can impair the acidification and
function of lysosomes, which are necessary for clearance
of intracellular Aβ.
The disease causes an accumulation
of mucopolysaccharides, or glycosaminoglycans (GAGs) due to the impaired
functioning of lysosomal enzymes that break down GAGs which help build bones, cartilage, skin, tendons, corneas and the fluid responsible for lubricating joints.
The mucopolysaccharides, which aid in bone formation, as well as that
of the skin, cornea and cartilage, don't perform their
function properly because
of a lack
of lysosomal enzymes.