Sentences with phrase «of mmps»

We seek to understand the functions of MMPs in this normal physiological process to use these findings to understand the tumor microenvironment.

Excessive proteolytic activity of MMPs can be detrimental, leading to numerous pathological conditions, including blood brain barrier (BBB) / BSCB disruption after injury,» explains Tae Young Yune, PhD, of the Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea.

Batimastat is designed to bind to zinc atoms in the active sites of all MMPs.

Competition policy (SME focus; need for equity; treat SMEs as «consumers» when dealing with larger businesses - extend unfair terms contracts to small business; need «legal precedents or statutory definitions» as part of unconscionable conduct framework); competition laws (focus on unfair terms and unconscionable behaviour; mention of MMP but not in context of s 46; access - call for broader access; price signalling (not clear)-RRB-; administration

In August 2012, the initial report on a review of the MMP system by the Electoral Commission recommended abolishing the one electorate seat threshold, meaning a party winning an electorate seat but not crossing the 5 % threshold (which the same report recommends lowering to 4 %) is only awarded that electorate seat.

[5] This article focuses primarily on semi-proportional implementations of MMP designed to yield moderately proportional election results, similar to the mixed systems used in the UK and referred to locally as AMS.

When the team asked the participants whether they smoked, they discovered that the smokers tended to have high levels of MMP - 1 mRNA.

The authors hope that this study will encourage companies to explore clinical testing of such drugs — or other modes of MMP - 9 inhibition — in patients with ALS.

Progeny from this cross with no MMP - 9 exhibited an 80 - day delay in loss of fast - fatigable motor neuron function and a 25 percent longer lifespan, compared with littermates with two copies of the MMP - 9 gene.

Therefore, the MRI signal indicated the location of MMP - 2, and the tumor.

The inhibition of MMP - 3 may be a promising therapeutic target for human central nervous system disease, including SCI,» notes Dr. Yune.

Injection of MMP - 3 into normal spinal cord also significantly increased dye leakage.

The design of MMP inhibitors (MMPIs) has largely focused on development of various compounds containing a zinc binding group (ZBG) in their structure, with the hydroxamate being the most potent one.

PMA transactivation of EGFR is involved in the regulation of MMP secretion, in particular of MMP - 1, MMP - 9, and MPP - 10.

Independent of MMP activity, TIMP - 1 can promote growth and inhibit apoptosis through various pathways, including P13K and PKA [9] and, furthermore, TIMP - 1 is able to provide β cell - specific pro-survival effects [5, 6, 10].

Although epithelial cells acutely exposed to matrilysin rapidly undergo apoptosis, constitutive expression of MMP - 7 selects for cells with a reduced sensitivity to apoptosis.

A) Gelatin zymography of MMP - 2 in conditioned media of HUVEC after treatment with different kahweol concentrations.

Our results in the zymographic assays for gelatinase and urokinase activities clearly showed that, in fact, kahweol was able to inhibit the expression of both MMP - 2 and uPA, identifying them as two relevant molecular targets for kahweol.

Long - term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up - regulation of mmp - 3 mrna in a model of spontaneous osteoarthritis in hartley guinea pigs.

Jefferson Research's ratings of MMP is very strong.

The article provides a good description of the bone cutting TPLO and TTA procedures but has no discussion of the MMP procedure probably because of the newness of this procedure.

It reminds me of Origin back in 1999 after the success of Ultima Online when the studio announced that it would forsake any further single player game development in favor of all MMP games.

Not exact matches

Before she was sworn in as head of the SBA in 2009, Mills was president of the private - equity firm MMP Group, which invested in businesses in the consumer products, food, textiles and industrial components industries.

According to a bio from Arrow Electronics, where she's a director, she's served since 1993 as the president of the Brunswick, Maine - based private equity group MMP Group and until 2007 was a founding partner in Solera Capital, a private equity partnership in New York.

Overview Fact Sheet for the MMP — BOEM is tasked with managing the extraction of offshore minerals from America's Outer Continental Shelf (OCS).

Magellan Midstream Partners» (MMP) 15 % ROGIC is the highest of all Large Cap Energy companies under coverage.

BOEM's Marine Minerals Program (MMP) is multi-faceted, focusing on coordinated leasing of sediment for extraction, inventorying sediment resources through geological and geophysical surveys of the Outer Continental Shelf (OCS), and environmental studies and reviews to inform decisions.

Broiled salmon is also available at many Mexican restaurants for a healthy dose of omega - 3s (one of which research suggests may help protect against UV - induced skin damage) Eicosapentaenoic acid inhibits UV - induced MMP - 1 expression in human dermal fibroblasts.

Sims» speech also sets out the ACCC's activities in relation to a number of areas of competition law (cartels, anti-competitive agreements and practices, MMP (noting the ACCC has «about» 10 in depth investigations underway)-RRB- and touches on the Harper Review and Murray Report as well as key issues surrounding privatisation, communications and water.

Strengthen CCA to «outlaw predatory conduct that has negative effects on competition, value chain suppliers and ultimately consumers» (p 1); MMP (amend s 46 to outlaw predatory conduct), unconscionable conduct (needs to be strengthened), unfair terms (extend to business and further guidance), collective bargaining (claims ineffective; wants collective boycott option), Code of Conduct (wants mandatory code).

«Have your say» Apply ACL (stet) to small business in relation to unilateral conduct, MMP, unfair and unconscionable conduct, third line forcing [no further explanation of how law does not currently apply to small business or why extension needed]

Changes to competition laws (milk wars discussion and recommendations relating to MMP (introduce effects test), predatory pricing (recommend Minister direct ACCC to investigate Coles for breach of s 46 relating to predatory pricing), unconscionable conduct (suggest it be defined), statutory duty of good faith, unfair contract terms (seeks «recognition of the competitive disadvantage faced by farmers» and extension of unfair contract terms protection to small business), collective bargaining (seeks relaxation of public interest test for boycott approvals in agriculture markets, increase «ability for peak bodies to commence and progress collective bargaining and boycott applications» on behalf of members - and further dairy specific recommendations, ACCC divestiture power (wants ACCC to have similar divestiture powers to Comp Commission in UK - «simpler process of divestiture», ACCC monitoring powers (wants Minister to direct ACCC to use price monitoring powers to «monitor prices, costs and profits relating to the supply of drinking milk») and mandatory code of conduct (wants mandatory code and «Ombudsman with teeth to ensure compliance»)-RRB-.

Capsaicin induces the sustained activation of EGFR downstream signals through the induction of EGFR transactivation mediated through Src and MMP - dependent mechanisms.

Maybe Cole is better because of the overall newness; Strom and clubhouse, different approach and positioning, learning McCann and vv, MMP and the AL, or pitch type linear weighting?

We found that mothers» reported use of infant lotion, infant powder, and shampoo was significantly associated with MEP, MMP, and MiBP urinary concentrations.

Re Germany: MMP seems like one of the better systems in active use, but just from the wikipedia page there are clear examples of minor parties not being properly represented.

3 Overhang With MMP you may have an «overhang» This is a potential mathematical problem which may occur depending on the outcome of the election.

1 Two kinds of MP With MMP there are two types of MP, those elected as constituency MPs and those elected from the Party List.

Germany and New Zealand both use MMP, and the result in each case is a slightly altered version of a two - party system.

Germany also has a tradition of grand coalitions between its two main parties, but New Zealand shows the system can work even when there isn't that kind of bipartisan collaboration (as, let's be honest, there wouldn't be in a hypothetical United States with MMP).

It is a PR system that addresses both the weaknesses of FPTP, and the disadvantages of the Mixed Member Proportional (MMP) and Single Transferable Vote (STV) systems, and so neutralises most of the arguments for keeping FPTP.

In June 2016, the House of Commons of Canada Special Committee on Electoral Reform was formed to examine potential changes to the voting system with MMP being one of the options examined.

The most widely used families of PR electoral systems are party list PR, the single transferable vote (STV), and mixed member proportional representation (MMP).

[7] It was the way that compensatory seats were allocated that made their report the origin of the additional member system, the term which the report also invented, which was then applied along with the much older «mixed system» by English - speaking writers on voting systems to West Germany's system and similar models until mixed member proportional (MMP) was invented for the adoption of the German system proposed for New Zealand in a royal commission report in 1986, which would explain why AMS and MMP have been used as synonyms.

The additional member system (AMS), also known as mixed - member proportional representation (MMP) outside the United Kingdom, [1][2][3][4] is a mixed electoral system with one tier of single - member district representatives, and another tier of «additional members» elected to make the overall election results more proportional.

These proteins, known as matrix metalloproteinases (MMPs), help cancer cells escape their original locations by cutting through proteins of the extracellular matrix, which normally holds cells in place.

These particles congregate at tumor sites, where MMPs cleave hundreds of peptides, which accumulate in the kidneys and are excreted in the urine.

Tumours spread with the help of enzymes called matrix metalloproteinases (MMPs), which destroy the connective tissue between cells and organs, allowing tumour cells to break out of the original site and enter new ones.

Griffiths also notes that emphysema, a lung disease common in smokers, is marked by a loss of connective tissue and may be related to increased MMP - 1 levels.

Apparently, one of the thousands of chemicals in tobacco causes MMP - 1 levels to go up.