Sentences with phrase «of melanoma research»

«We saw the success of the melanoma research program and asked ourselves, «Is there something else we can do for other diseases?»»

Results of the international trial, led by principal investigator Jeffrey S. Weber, MD, PhD, the Laura and Isaac Perlmutter Professor of Oncology, deputy director of Perlmutter Cancer Center, and co-leader of its Melanoma Research Program, were published in November 2017 in The New England Journal of Medicine.

Keiran S. Smalley, Ph.D., scientific director of the Melanoma Research Center of Excellence, and his team began investigating this pathway in 2010 and discovered the best way to block its ability to promote cancer cell growth was with combined inhibitor therapy.

«Our findings provide a possible flanking strategy to counteract the ability of melanoma cells to re-wire their signaling networks,» said co-coresponding author Meenhard Herlyn, Caspar Wistar Professor in Melanoma Research and director of the Melanoma Research Center at The Wistar Institute.

Memorial donations may be made in honour of Shawn Price to the Cancer Center of Melanoma Research at CPMC Sutter Health Foundation: www.cpmc.org/giving.

Not exact matches

Master of Science candidate in Biomedical Sciences at Mississippi College, Bilal Qizilbash, summarizes his research breakthrough in a nutshell: Juiced curly kale kills melanoma...

I would add that it is of utmost importance to prevent sunburns in kids, as the research shows that the risk of melanoma is greatly increased when kids between 0 and 10 get sunburns.

Horizon has partnered with The Wistar Institute of Anatomy and Biology in Philadelphia, Pennsylvania, to make available their large collection of highly characterized Melanoma PDX models to the research community; these models are representative of all previously well - described melanoma subtypes identified by The Cancer GenomMelanoma PDX models to the research community; these models are representative of all previously well - described melanoma subtypes identified by The Cancer Genommelanoma subtypes identified by The Cancer Genome Atlas.

A Ludwig Cancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunotherapy.

They are following up on some of the parallel pathways downstream of PAK to determine how they operate, and are also pursuing research into immunotherapy approaches in melanoma treatment.

A type of soil - dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows.

Survivors of melanoma were more likely to limit exposure to the sun than people who had never had the disease, but some still reported seeking out suntans and getting sunburns, reports a new article in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research by Rachel Isaksson Vogel, PhD, an assistant professor in the Department of Obstetrics, Gynecology and Women's Health at the University of Minnesota.

Cancer Research UK scientists at The University of Manchester found that some melanoma cells are particularly fast growing, but not very good at invading the surrounding tissue, while other melanoma cells are the opposite — highly invasive but slow - growing.

Professor Richard Marais, director of the Cancer Research UK Manchester Institute, said: «Malignant melanoma is the most deadly form of skin cancer precisely because it spreads quickly and aggressively.

Ms Alice Koechlin, from the International Prevention Research Institute in Lyon, France, told the meeting that people who were at highest risk of dying from melanoma were those born between 1900 and 1960 when not only were the dangerous effects of exposure to ultraviolet (UV) radiation from sunlight largely unknown, but also health professionals believed that sunshine was positively beneficial.

Martin's colleague Catherine Suter of the Victor Chang Cardiac Research Institute in Sydney is studying whether melanoma patients have epimutations in genes associated with the cancer.

Research teams focused on both cutaneous and uveal melanoma are fast - tracking discoveries into the clinical setting, and bringing novel therapeutic options to patients in the Philadelphia region,» said Karen Knudsen, Director of the Sidney Kimmel Cancer Center.

«Dr. Aplin's major research advance is part of a larger effort by the Sidney Kimmel Cancer Center to develop new strategies for treating melanoma.

Researchers from the Spanish National Cancer Research Centre (CNIO) have discovered more than 40 genes that predict the level of aggressiveness of melanoma and that distinguish it from other cancers with a poor prognosis.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout tMelanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout tmelanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.

The research could lead to development of new strategies to slow melanoma growth by targeting DNMT3B, say the researchers.

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

In the April 25 issue of Cancer Cell, a research team, led by Xin Lu, PhD, Ludwig director and member at the University of Oxford and a team of scientists from both institutions, describes how p53 is silenced in advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cells.

«While more research is needed, this study shows that patients in the study had markers of poor prognosis for their melanoma.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Dr Wells» team has previously published research on the importance of PAK4 in other types of cancer, including prostate, breast and melanoma.

In the past decade, medical research has discovered direct links between tanning bed use and higher rates of the skin cancers basal cell carcinoma, squamous cell carcinoma and melanoma.

In the past decade, medical research has discovered direct links between tanning bed use and higher rates of the skin cancers basal cell carcinoma, squamous cell carcinoma and melanoma, according to Dr. Thomas.

The first such drug, called ipilimumab (Yervoy), developed out of Allison's basic science research, showed much lower response rates against advanced melanoma than those obtained with targeted drugs, but long - term follow - up found that 22 percent of those treated with Yervoy survived at least four years, unprecedented results for the disease.

Overall, patients with Parkinson's were roughly four times likelier to have had a history of melanoma than those without Parkinson's, and people with melanoma had a fourfold higher risk of developing Parkinson's, the research found.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

New research links specific inherited genetic differences (alterations) to an increased risk for eye (uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color.

«Our research is making a real difference to understanding what causes melanoma and ultimately therefore how to prevent and treat melanoma and is a prime example of how genomics can transform public health,» says Professor Julia Newton Bishop, co-senior author from the University of Leeds.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

That is why «early diagnosis is the best tool we have to date for saving patients.In fact, patients with early - stage melanoma have a survival rate of 95 %, while5 - year survival falls to 50 % in patients with metastasis,» explained Yoana Arroyo, researcher in the UPV / EHU's department of Cell Biology and Histology, where this research was carried out.

«This is a very important discovery that will guide future research efforts to explore the interactions of these pigmentary genes with other genetic and environmental risk factors in cancers not linked to sun exposure, such as eye melanoma.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

«Increased eye cancer risk linked to pigmentation genes that dictate eye color: New research identifies genetic mechanisms behind rare form of melanoma are also associated with genetic risk for skin melanoma.»

«Federal funding will be crucial to support research of rare cancers such as eye melanoma as it is likely, as shown in this study, that the impact of such research will extend across the different cancer types,» adds Abdel - Rahman.

«We have found that the individual cells within melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Researchmelanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Researchmelanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma ResearchMelanoma Research Center.

Moreover, many people don't apply the proper amount of sunscreen, forget to reapply and missed to apply on all exposed areas resulting in sunburn and increased risk of melanoma,» said Reza Ghiasvand, a PhD candidate at The Department of Biostatistics and a member of the research group «Epidemiological Studies of Lifestyle and Chronic Diseases.»

The team expected to find obesity to be harmful for melanoma patients, based in part on research that implicates obesity in activation of a cancer - promoting molecular pathway called IGF - 1 / PI3K / AKT.

Fresh research at Sahlgrenska Academy has found that antioxidants can double the rate of melanoma metastasis in mice.

The research behind the melanoma finding and Martensen's ALK test began in the 1970s, when a young oncologist named Dennis Slamon became obsessed with the genetics of breast cancer.

«Our findings point to two potential impacts from additional research — analyzing the diversity and composition of the microbiome to predict response to immunotherapy and modulating the gut microbiome to enhance treatment,» said Wargo, senior researcher on the project and co-leader of the Melanoma Moon Shot ™, part of MD Anderson's Moon Shots Program ™ to reduce cancer deaths by accelerating development of therapies from scientific discoveries.

The second report, identifies the immunotherapy resistance mechanism in melanoma cells, is from a group led by Kai Wucherpfennig, MD, PhD, director of Dana - Farber's Center for Cancer Immunotherapy Research, and Shirley Liu, PhD, of Dana - Farber.

«The idea is to use a less severe disease as a weapon against malignant melanoma,» says Dr. Jasper van den Boorn from the Institute of Clinical Chemistry and Clinical Pharmacology of the University of Bonn, who previously researched this connection in his doctoral thesis at the University of Amsterdam and demonstrated the fundamental feasibility of this option.

Prof. Marine and his research team also identified a pharmacological way of restoring the expression of FES in human melanoma.