Host: Dr. Alex MacKay Speaker: Dr. George Harauz, Univ. of Guelph Title: Myel - Stones or The Executive Roles
of Myelin Basic Protein in Myelin Assembly and Destabilization in Multiple Sclerosis
Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products
of the Myelin Basic Protein Gene.
Not exact matches
The researchers tested these cells on a batch
of mice that had been injected with
myelin basic protein, which triggers the autoimmune response and causes EAE symptoms to occur in about 2 weeks.
Proline substitutions and threonine pseudophosphorylation
of the SH3 ligand
of 18.5 - kDa
myelin basic protein decrease its affinity for the Fyn - SH3 domain and alter process development and
protein localization in oligodendrocytes.
The pathogenesis
of this appears to be based on an immunological reaction against the
basic protein in
myelin that is triggered by the distemper virus.