Hugo de Jonge, an associate professor at Erasmus Medical Center in The Netherlands and director of the MDI Biological Laboratory's new biomedical innovation course, «Applications
of Organoid Technology,» discusses the potential of this fascinating new «mini-organ» technology in this exclusive editorial in Regenerative Medicine Network.
The MDI Biological Laboratory has announced that it will offer a one - week intensive course May 27 through June 2, 2018, entitled «Applications
of Organoid Technology» in partnership with Hubrecht Organoid Technology (The HUB), a non-profit organization based in Utrecht, Netherlands.
BAR HARBOR, MAINE — The MDI Biological Laboratory in Bar Harbor, Maine, has announced that it will offer a one - week intensive course May 27 through June 2, 2018 entitled «Applications
of Organoid Technology» in partnership with Hubrecht Organoid Technology (The HUB), a non-profit organization based in Utrecht, Netherlands.
«The use of a mouse tumor - derived matrix would limit any future applications
of these organoid technologies in humans, and this work opens the door to research directed specifically for clinical applications,» noted Asma Nusrat, study co-author and the Aldred Scott Warthin Professor and Director of Experimental Pathology in the University of Michigan's School of Medicine.
Not exact matches
«It is highly likely that
organoids will revolutionize therapy
of many severe diseases,» says Rudolf Jaenisch, a stem cell scientist at the Massachusetts Institute
of Technology in Cambridge.
Stem cell
technology has advanced so much that scientists can grow miniature versions
of human brains — called
organoids, or mini-brains if you want to be cute about it — in the lab, but medical ethicists are concerned about recent developments in this field involving the growth
of these tiny brains in other animals.
However, despite its marked promise for disease modeling, development
of novel therapies, and regenerative medicine, stem cell derived
organoid technology faces many remaining challenges.
Due to the high efficiency
of establishing
organoid models from different tissues and diseases, such as cancer,
organoid technology allows the generation
of large living biobanks
of tumor
organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).
The
organoid technology field has advanced enormously as a result
of two key discoveries.
The directors
of the
organoid course are Hugo de Jonge, Ph.D, professor at Erasmus University Medical Center (Erasmus MC) in Rotterdam, Netherlands, and a visiting professor at the MDI Biological Laboratory, and Robert Vries, Ph.D., managing director at Foundation Hubrecht Organoid Tec
organoid course are Hugo de Jonge, Ph.D, professor at Erasmus University Medical Center (Erasmus MC) in Rotterdam, Netherlands, and a visiting professor at the MDI Biological Laboratory, and Robert Vries, Ph.D., managing director at Foundation Hubrecht
Organoid Tec
Organoid Technology.
The team used pancreatic
organoid technology developed in the lab
of Professor David Tuveson, Director
of CSHL's Cancer Center and Director
of Research for the Lustgarten Foundation.
«Our
organoid course is one
of only a handful in the United States to offer an intensive experience in
organoid technology.
ANN ARBOR, Mich — By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as
organoids — made from human pluripotent stem cells — researchers have taken an important step toward creating a new
technology for controlling the growth
of these
organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).
The experts explain that many
of the state -
of - the - art
technologies are required to tease out relevant information from model systems, whether these be
organoids or «classical animal models such as the fruit fly, zebra fish or mouse,» adds Milán.
Researchers had developed the
technologies needed to create
organoids years before — how to grow cells in culture, how to isolate stem cells from human tissue, and how to coax the stem cells, undifferentiated and immature, to become specific types
of cells at later stages
of development.
Researchers from Brigham and Women's Hospital are leveraging these new
technologies to study the effects
of DISC1 mutations in cerebral
organoids - «mini brains» - cultured from human stem cells.
The new platform combines microfluidic lab - on - a-chip
technology with physiologically relevant spheroids to enable formation and long - term culture
of 3D multicellular tumours /
organoids for drug screening / profiling and individualized chemosensitivity testing.
Within the scope
of personalized medicine, this
technology presents immense possibilities for testing patient - derived multicellular tumour spheroids /
organoids (comprising cancer cells, stromal cells, cancer stem cells and / or immune cells) for disease / biomarker - oriented drug activity and profiling using single - and pair-wise standard / targeted drug combinations.