Sentences with phrase «of thiol»

Dröge W. Aging - related changes in the thiol / disulfide redox state: implications for the use of thiol antioxidants.

Effect of thiol antioxidant on body fat and insulin reactivity.

At the same time it increases the content of Thiol in the skeletal muscle neutralising various nitrogen - based radicals.

Based on this method of compound activity classification, we identified a class of thiol - reactive (electrophilic) HMOX1 inducing compounds, exemplified by HPP - 1014.

Knocking down levels of these thiols reduces cancer cells» ability to resist drugs.

Not exact matches

Designing molecules that selectively target thiols produced by cancer cells that cause drug resistance is the focus of many years» work by Dimmock, Das and their collaborators.

Team leader Jonathan Dimmock, a medicinal chemistry researcher in the U of S College of Pharmacy and Nutrition, explained their compounds work by interacting with thiols, naturally occurring chemicals that perform several roles in cells.

To see how a size disparity would affect the crystalline order and the system's physical properties, Olvera de la Cruz and postdoctoral fellow Zhenwei Yao devised a model system of soft particles, such as functionalized nanoparticles with grafted chains including nucleic acids or thiols.

Taken together, these findings indicate different redox requirements for the glutathione thiol / disulfide redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.

Light converts certain beer bitter acids to the dreaded 3 - methyl -2-butene-1-thiol (MBT) compound, a close relative of the malodorous thiols produced by Mephitis mephitis, the striped skunk.

The researchers achieved a full assignment of all signals to specific thiol ligands by using a combination of correlated nuclear magnetic resonance (NMR) experiments, density functional theory computations and molecular dynamics simulations.

A key test of chemical reactivity is to incubate the compounds with a thiol - containing reductant.

CDDO - Me reacted with thiol groups as determined by detection of specific adducts by LC - MS (Tables S1 and S2 and Figure S3 in Data S2).

HPP - 4382 does not have electrophilic properties, as determined by its structure and lack of chemical reactivity with common thiol - containing compounds such as N - acetylcysteine.

Thiol - reactive electrophilic compounds often increase ROS levels in cells, as a consequence of their ability to deplete glutathione.

Stefan L. Ameres, Institute of Molecular Biotechnology «SLAMseq: Thiol - linked alkylation for the metabolic sequencing of RNA»

Dissolved hydrogen sulphide, H2S (aq), then penetrates the wood, where it is transformed into solid reduced sulphur compounds, such as thiols, R - SH (R denotes an organic part), in the lignin of the wood and to iron (II) sulphides when iron ions are available.

Cutting Edge: Induction of the Antigen - Processing Enzyme IFN --LCB- gamma -RCB-- Inducible Lysosomal Thiol Reductase in Melanoma Cells Is STAT1 - Dependent but CIITA - Independent

Important achievements have been done in the preparation and characterization of: i) Gold nanoparticles stabilised through thiol derivatised organic - and bio-molecules; ii) nanocomposite coatings for low friction and high wear resistance applications and iii) new nanostructured materials for hydrogen storage.

Studies of both elderly subjects and cancer patients have found that the aging and disease related loss of skeletal muscle mass, or sarcopenia, is significantly related to the oxidative shift in the plasma thiol / disulfide redox status.

Changes in the thiol / disulfide redox status (discussed in Part II of this review in relation to the connections among homocysteine, methylation and transsulfuration) can also significantly inhibit the activity of the redox - sensitive phosphatases that regulate insulin signaling.

Cysteine remaining in the bloodstream will be oxidized to disulfide cystine, causing an undesirable shift in the thiol / disulfide status of the blood plasma, which in turn, will alter the set points of redox - sensitive signaling pathways.

Beyond FODMAPS, salicates, sulfur - high foods, histamines, amines, thiols, insoluble fiber, soluble fiber, nightshades, glycoalkaloids, phytoestrogens, and metal poisoning, insulin issues, adrenal issues all uniquely affecting frequency and types of foods that are most suitable...

Vegetarian diets are particularly deleterious to a significant subset of people suffering from mercury toxicity, because it is virtually impossible to obtain sufficient protein on a vegetarian diet that is modified to reduce free - thiol sources.

The late Andrew Cutler, author of Amalgam Illness: Diagnosis and Treatment56 and Hair Test Interpretation: Finding Hidden Toxicities57 noted that foods high in free thiol (which include legumes, dairy, the cabbage family and eggs) can provoke symptoms in a significant subset of mercury - affected people, in part by increasing plasma cysteine, which may rise in response to mercury and its biochemical effects.

They talk about the most important mechanism by which Mercury causes toxicity appears to be Mitochondrial damage via the depletion of Glutathione, coupled with binding to thiol groups, which generate free radicals.

Rather, some of the most effective phytochemicals appear to work via the PRO-oxidant reaction of their quinone metabolites with thiols on the sensor protein Keap1, releasing the transcription regulator Nrf2 into the nucleus to initiate an adaptive stress response.

Toxic Metals and Antioxidants Part II: The Role of Antioxidants in Arsenic and Cadmium Toxicity Alternative Medicine Review 2003 (May); 8 (2): 106 — 128 ~ FULL TEXT The metabolism and excretion of these heavy metals depend on the presence of antioxidants and thiols that aid arsenic methylation and both arsenic and cadmium metallothionein - binding.

Thiols have a lingering rotten egg odor, and the skunk's oily secretion makes it difficult to get rid of.