«I think the general thought process is: «These patients are not going to live long,»» said Dr. Mammen, Director
of Translational Research for UT Southwestern's Advanced Heart Failure Program.
Not exact matches
Dr. Michael Kurilla, director
of the Office
of Biodefense
Research Resources and
Translational Research at the NIH's National Institute
of Allergy and Infectious Diseases (NIAID), recently told Tech Insider that
for years, we thought certain viruses known as coronaviruses were relatively innocuous.
Director, Scripps
Translational Science Institute; Chief Academic Officer, Scripps Health; Professor
of Genomics, The Scripps
Research Institute, La Jolla, California; Editor - in - Chief, Medscape Disclosure: Eric J. Topol, MD, has disclosed the following relevant financial relationships: Serve [d] as a director, officer, partner, employee, advisor, consultant, or trustee for: AltheaDX; Biological Dynamics; Cypher Genomics (Co-founder); Dexcom; Genapsys; Gilead Sciences, Inc.; Portola Pharmaceuticals; Quest Diagnostics; Sotera Wireless; Volcano Received research grant from: National Institutes of Health; Qualcomm Fo
Research Institute, La Jolla, California; Editor - in - Chief, Medscape Disclosure: Eric J. Topol, MD, has disclosed the following relevant financial relationships: Serve [d] as a director, officer, partner, employee, advisor, consultant, or trustee
for: AltheaDX; Biological Dynamics; Cypher Genomics (Co-founder); Dexcom; Genapsys; Gilead Sciences, Inc.; Portola Pharmaceuticals; Quest Diagnostics; Sotera Wireless; Volcano Received
research grant from: National Institutes of Health; Qualcomm Fo
research grant from: National Institutes
of Health; Qualcomm Foundation
Andrew Borrell receives funding from the Australian Centre
for International Agricultural
Research, the Bill and Melinda Gates Foundation, and is an associate investigator with the ARC Centre
of Excellence
for Translational Photosynthesis.
Rush University Medical Center faculty and staff have been international leaders in conducting
translational research to provide the scientific evidence
for the use
of mothers» own milk to reduce complications in very low birthweight infants infants during the NICU hospitalization.
But Mohler, senior vice president
for Translational Research at Roswell Park Cancer Institute, responded that Albany needs to have a greater sense
of urgency.
More than 40 years after those early experiments, Jackson has risen to become the associate dean
for clinical
research and director
of Ohio State University (OSU) Medical Center's Center
for Clinical and
Translational Science (CCTS).
«The most common time there is conflict
of interest is not with inventorship,» says Harry Greenberg, senior associate dean
for research at the Stanford University School of Medicine in Palo Alto, California, and director of the Stanford Center for Clinical and Translational Education and R
research at the Stanford University School
of Medicine in Palo Alto, California, and director
of the Stanford Center
for Clinical and
Translational Education and
ResearchResearch.
The Wallace H. Coulter Foundation was another source
of support
for Berkland: The foundation awarded him a 2 - year Early Career
Translational Research Award in Biomedical Engineering, which is offered to academic research with commercial po
Research Award in Biomedical Engineering, which is offered to academic
research with commercial po
research with commercial potential.
They may have done a thesis with a
translational focus, but few will have received training in the requirements
for doing modern patient - oriented
research, which includes large doses
of epidemiology, statistics, and human - subject trial design.
With support from Ohio State's Center
for Clinical and
Translational Science (CCTS), Dr. Bonny's
research team was able to comb through past
research to identify the top 30 nutrients that were most likely to influence the growth
of fat tissue in a low - estrogen environment.
For me, it is satisfying to answer that call and be part
of our society's effort to improve health through basic and
translational research.
Fortunately, I identified a niche
for myself in the field — a novel area
of research in
translational control — and wrote a proposal jointly with a permanent member
of faculty at the University
of Sussex, U.K., who had actually taught me years earlier.
Support
for translational research has helped with the development
of new drugs, diagnostics and vaccines, Hotez says, but funding
for basic
research has lagged behind.
The NIH continues to promote
translational research with the creation of the National Center for Advancing Translational Sciences (NCATS) as a «bold, new, focused center systematically engineered to accelerate transl
translational research with the creation
of the National Center
for Advancing
Translational Sciences (NCATS) as a «bold, new, focused center systematically engineered to accelerate transl
Translational Sciences (NCATS) as a «bold, new, focused center systematically engineered to accelerate translation.»
In the United States, most training opportunities are through the Clinical and
Translational Science Awards (CTSAs), which were launched in 2006 based on the 2003 National Institutes
of Health (NIH) Roadmap
for Medical
Research.
The budget
for translational health
research since 2007 has been 12 million euros, representing 3 %
of health
research training programs
for the Marie Curie Actions, according to Georges Bingen, the European Commission's head
of unit
for the Marie Curie Actions People Programme.
In the interest
of translational research, the acquired knowledge is to be applied to humans as quickly as possible in order to provide concrete benefits
for society.
The pioneering
research led by academics from the Sheffield Institute
of Translational Neuroscience (SITraN), in collaboration with scientists from the University
of York, supports the fast - tracking
of the drug ursodeoxycholic acid (UDCA)
for a clinical trial in Parkinson's patients.
Professor Paolo Boffetta (MD), the Annals
of Oncology associate editor
for epidemiology and Director
of the Institute
of Translational Epidemiology at the Icahn School
of Medicine at Mount Sinai in New York (USA), commented: «These results are extremely important in showing that reducing cancer mortality can be achieved: priority should be given to
research in cancers with unfavourable trends, such as pancreatic cancer, and in reducing cancer mortality disparities, both between countries (Central / Eastern versus Western Europe), and within countries,
for example, between socioeconomic groups.
Using genomic analysis to study cancer in dogs can help develop new therapies
for humans with cancer, according to a proof -
of - concept study led by the National Cancer Institute (NCI) and the
Translational Genomics
Research Institute (TGen).
Research reported in this news release was supported by the National Heart, Lung and Blood Institute
of the National Institutes
of Health (NIH) under award number R01 HL116585 - 01 and the National Center
for Advancing
Translational Sciences
of the NIH under award numbers UL1TR000075 and KL2TR000076.
An internationally - recognized scientist with more than 16 years
of experience in
translational immunoparasitology
research and vaccine development
for neglected tropical diseases, Bottazzi's major interest lies in the role
of vaccines as control tools integrated into international public and global health programs and initiatives.
In this way, Louvard believes the institute will gain most from its mix
of research disciplines and potential
for translational research, involving anything from theoretical physics and pharmacochemistry through cell biology and radiobiology to imaging and bioinformatics.
Such an interdisciplinary approach requires more than just taking ideas from a foreign field back to your home turf, Sarah Gehlert, director
of the Center
for Interdisciplinary Health Disparities
Research (CIHDR) at the University of Chicago, said in February during a panel discussion on translational research at the AAAS annual meeting in
Research (CIHDR) at the University
of Chicago, said in February during a panel discussion on
translational research at the AAAS annual meeting in
research at the AAAS annual meeting in Chicago.
The National Institutes
of Health's (NIH's) Roadmap
for Medical
Research acknowledges the importance of behavioral and social science research, and the agency's Clinical and Translational Science Awards require a behavioral science component in the programs of awardee insti
Research acknowledges the importance
of behavioral and social science
research, and the agency's Clinical and Translational Science Awards require a behavioral science component in the programs of awardee insti
research, and the agency's Clinical and
Translational Science Awards require a behavioral science component in the programs
of awardee institutions.
The portal now offers easy navigation
of Science's table
of contents
for quick access to the most recent scientific
research published in Science, Science
Translational Medicine, and Science Signaling — plus an option to sign up
for Science's E-mail Alert in Japanese featuring
research highlights from all three journals.
Focusing on basic
research for the functional regulation
of innate and adaptive immunity and on
translational research for cancer immunotherapies, the National Key Laboratory
of Medical Immunology has been conducting innovative
research and exploration, and is becoming a rising star in the international immunology community.
«Bioinformatics Instruction & Consultation, Collaboration, Evaluation» [PDF, 2.38 MB] Kristi L. Holmes, Ph.D., Becker Medical Library, Washington University in St. Louis «Community Engagement: Lost in Translation» [PDF, 2.1 MB] Layne Johnson, Ph.D., Clinical and
Translational Science Institute, University
of Minnesota «Supporting Clinical
Research» [PDF, 785 KB] Jennifer A. Lyon, M.S., MLIS, Biomedical and Health Information Services, University
of Florida «Library - based Support
for Translational Medicine» [PDF, 403 KB] Michele R. Tennant, Ph.D., MLIS, Biomedical and Health Information Services, University
of Florida
Together with the European Renal cDNA Bank and the Joint Institute
for Translational and Clinical
Research (a collaboration between Peking University Health Sciences Center and U-M), the U-M team found a simple, new test to identify one
of the nation's fastest growing chronic illnesses.
A team under Professor Scheffler, consisting
of researchers from the Bonn University Hospital, the Life & Brain Center, The German Consortium
for Translational Cancer
Research, Tufts University Boston / Massachusetts, and other institutes in the USA, has now developed a new method that is expected to combat such complex brain tumors better.
«We are excited by the work
of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role
of myc pathway dysregulation in multiple myeloma, and ultimately allow
for the development
of therapeutic strategies to address it,» said Jeffrey Wolf, MD, a UCSF blood disorder specialist and director
of the Stephen and Nancy Grand Multiple Myeloma
Translational Initiative at UCSF, a sponsor
of the
research.
Other researchers include Randy Strong, Department
of Pharmacology and Barshop Institute
for Longevity and Aging Studies, UTHSC, San Antonio, TX; Clifford Rosen, Center
for Clinical and
Translational Research, Maine Medical Center
Research Institute, Scarborough, ME; and Michael Nelson, Heart Institute, Cedars - Sinai Medical Center, Los Angeles, CA.
Magnus Dustler, MSc in Engineering and a doctoral student at Department
of Translational Medicine, Lund University, shows in his
research how it is far from certain that strong compression
of the breast results in an image which improves the doctors» possibilities
for diagnosis.
Back in the US, and further along the
translational pipeline is Doug Lowy,
of the NIH in Bethesda, Maryland, who has already experienced the potential
of harnessing basic
research for clinical use.
Beyond the rigorous
research education essential
for all scientists,
translational scientists who will work at the boundaries
of discovery and clinical science must possess an assortment
of practical and logistical skills.
The study was supported by the Eunice Kennedy Shriver National Institute
of Child Health and Human Development (K23 HD054720), Flora Family Foundation, UCSF Catalyst Award, UCSF Resource Allocation Program, Brain & Behavior
Research Foundation Young Investigator Award, Stanford University Lucile Packard Foundation
for Children's Health, Spectrum Child Health & Clinical and
Translational Science Award and the Extraordinary Brain Series
of the Dyslexia Foundation.
For Fuster, «This is a clear example
of the type
of the collaborative and
translational research favored by the CNIC, in which
research groups with different interests and perspectives collaborate on clinical problems that would not be easily resolved by teams working in isolation.»
«Clinical and
translational medicine represents an important arena
of investigation ripe
for 21st - century science diplomacy, beginning with — although by no means limited to — infectious disease
research,» he and co-author Vaughan Turekian, chief international officer and director
of the AAAS Center
for Science Diplomacy, write.
The journal's home page explains that
translational medicine «builds on basic
research advances — studies
of biological processes using cell cultures,
for example, or animal models — and uses them to develop new therapies or medical procedures.»
«We are excited that our
translational research team
of clinicians and basic researchers have come together to present these novel findings and hope that future studies and trials based on this work can move forward to bring targeted therapies
for TED,» commented Dr. Phipps.
The SHOW project is supported by grants from the Wisconsin Partnership Program, the National Institutes
of Health (IRC2HL101468 - 01), and the UW Institute
for Clinical and
Translational Research (KL2 - RR025012).
«Since several BACE1 inhibitors are currently being evaluated in clinical phase 3 trials
for the treatment
of Alzheimer's disease, the identification
of potential side effects will be
of great importance to ensure a positive clinical outcome,» said Dr. Jochen Herms, a Professor
of translational brain
research at Ludwig - Maximilians - University Munich.
«Activation
of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup
of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director
of Georgetown's Laboratory
for Dementia and Parkinsonism, and scientific and clinical
research director
of the GUMC
Translational Neurotherapeutics Program.
The lab
of co-author Dr. Robert Bast Jr., an expert in ovarian cancer and vice president
for translational research at MD Anderson, inserted gel - bound carbon nanotubes into the ovaries
of rodents to mimic the accumulations that are expected
for nanotubes linked to special antibodies that recognize tumor cells.
«The exciting
research results being presented today underscore how transplants are becoming an increasingly successful treatment option
for more patients with blood cancer than ever before,» said Jeffrey Miller, MD, moderator
of the press conference and Deputy Director
of the Masonic Cancer Center and the Clinical and
Translational Sciences Institute at the University
of Minnesota in Minneapolis.
His primary clinical and
research focus is dementia, with specific areas
of interest including biomarkers to assist in the diagnosis and understanding
of disease mechanisms
for Alzheimer's and Parkinson's disease, and
translational research using novel therapeutic approaches.
Her
research is both
translational and clinical in nature and centers on the human genetics
of healthy skin aging and diseases related to aging skin, including new treatments
for advanced basal cell skin cancers.
«We've known
for several years that people working directly with livestock are at increased risk
for MRSA infections, but this is one
of the first studies providing compelling evidence that everyday consumers are also potentially at risk,» says Lance Price, PhD, Director
of the Antibiotic Resistance Action Center, which is based at Milken Institute SPH, and Director
of Translational Genomics
Research Institute Center
for Food Microbiology and Environmental Health.
«You shouldn't be testing everybody, but if there are reasons to believe that a test
for H. pylori may come back positive, and it does come back positive, you should go on to treat,» says Dr. Traci Murakami, previous gastroenterology fellow at the UA and graduate
of the clinical and
translational research graduate certificate at the Mel and Enid Zuckerman School
of Public Health, now an assistant clinical professor
of medicine at the University
of Hawaii, Manoa, and lead author
of the study.