Sentences with phrase «of tumor suppression»

For the first time, the researchers showed an upregulation of this tumor suppression gene as they added more and more of the blended apple peels to each of the cancer types.

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

Lloyd Trotman Molecular mechanisms of tumor suppression; cancer modeling and treatment; molecular cancer visualization; PTEN regulation

Latest discoveries of the team «Genetics of Tumor Suppression (CNRS, Institut Curie)» managed by Franck Toledo, University Pierre and Marie Curie Professor, recently published in Nature Communication should enable to better understanding mecanisms at stake in the Fanconi Anemia.

But some of the tumor suppression genes didn't recover and remained forever altered.

Not exact matches

The study results builds on prior investigations by the research team which demonstrated that activation of the PI3K pathway by PTEN tumor loss created a «microenvironment» allowing tumors to evade immune suppression.

Less suppression of the immune response and less blood vessel formation in the tumor leads to less tumor growth.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

Isoprenoid - mediated suppression of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate.

The more robust tumor reduction and suppression of escape pathways possible with PMILs might enable curative surgery or improve the outcome of chemotherapy to enhance patient survival.

«Our work has shown that overcoming brain tumor - induced immune suppression is critical for enhancing efficacy of anti-tumor immunotherapies,» says first author Neha Kamran, Ph.D., a U-M neurosurgery research fellow in the Castro / Lowenstein Lab.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

We have examined the involvement of p21 in tumor suppression by following a large cohort of p21 - deficient mice for an extended period of time.

In this study, we have addressed the role of p21 in tumor suppression by directly assessing the susceptibility of p21 - null mice to spontaneous tumors and also to radiation - induced tumors.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

Mechanisms that link tumor suppression and the development of cancer to aging and the major diseases associated with aging

P21 is closely related to the tumor suppressor gene P53: cancer suppression and enhanced regeneration are frequently found to be opposite sides of the same coin.

We conclude that p21 plays a significant role in tumor suppression, which is more important than that of Bax but weaker than that of p53 or its upstream regulators ATM and p19ARF.

Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.

Tumor cell programmed death ligand 1 - mediated T Cell suppression is overcome by coexpression of CD80.

In recent years, therapeutics aiming to restore the tumor suppression function of the immune system have shown impressive clinical results, but not all cancer patients benefit from these.

iTeos» pipeline addresses key unmet needs in immuno - oncology: the inhibition of immune suppression in inflamed (hot) tumors and the increase of immunogenicity in non-inflamed (cold) tumors.

Title: Two sides of the Myc - induced DNA damage response: from tumor suppression to tumor maintenance Authors: Campaner S and Amati B Date: 2012 Publication Details: Cell Division 2012; 7 (1): 6

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

Many studies in tumor models have forcibly provided 4 - 1BB signals, injecting either agonist antibodies to 4 - 1BB, or transfecting 4 - 1BBL into the tumor cells, also highlighting the stimulatory capability of 4 - 1BB in driving suppression of tumor growth largely through augmenting CTL and NK responses.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Studies by ours and other groups have shown that a number of EphA2 and EphA3 mutations inactivate Eph receptor canonical signaling by disrupting ephrin binding or kinase activity, consistent with a role of canonical signaling in tumor suppression.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

Dr. Matsuzaki has accumulated extensive expertise in T - cell biology and mechanisms of immune suppression in periphery and tumor microenvironments in patients with ovarian cancer.

Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C - reactive protein, interleukin - 6, tumor necrosis factor alpha, and adiponectin; and did not significantly affect other risk factors for coronary heart disease (blood pressure and plasma glucose, insulin, and lipid concentrations) in either group.

Thus, upon activation by ActD, AKT becomes an inducer of p53 tumor suppression instead of being a survival factor, as consistently shown in human embryonic kidney cell lines (293 and 293T), human hepatoma cell line (HepG2), and mouse hepatoma cell line (Hepa - 1c1c7).

In - vivo treatment of HCC1806 tumors with MIA - 602, doxorubicin, or combination resulted in significant (P < 0.01) suppression of MDR1 and NANOG gene expression relative to controls.

It may be pivotal in the tumor - induced suppression of anti-tumor T cell responses.

Whether these defects are due to improper T cell activation by dysfunctional antigen presenting cells, suppression by the tumor microenvironment, or by improper homing of the «correct» T cells to the tumor is not known.

Dr. Gollnick's laboratory explores how tumor cells co-opt the host immune system to promote chronic inflammation that leads to increased vascularization, suppression of anti-tumor immunity and increased tumor cell proliferation and migration.

Potential anti-inflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor α, interleukin 1, and prostaglandin E2

But then, in 2006, researchers in Canada working with breast - cancer cells found that metformin increased the activity of an enzyme involved in tumor suppression, suggesting that the drug might fight cancer by working directly on cancer cells.

If this is not feasible for any reason, suppression of the tumor with Lysodren is sometimes effective.

In an attempt to tell whether the tumor is in the pituitary or in the adrenal gland, the vet may attempt a high dose dexamethasone suppression test (about 80 % of Cushing's dogs have the tumor in their pituitary gland).

This condition, extremely common in middle - aged and senior ferrets, occurs when tumors form in one or both adrenal glands, resulting in the release of hormones that can cause hair loss, itchy skin, anemia, prostate gland enlargement in males (with potential fatal urinary tract obstruction), and bone marrow suppression.

A high - dose dexamethasone suppression test can then be performed to classify the location of the tumor.