Sentences with phrase «of valproate»

«EPIGENETIC THERAPY OF LUNG CANCERS: Anti-tumoral effect of valproate on small cell lung cancer».

Study of the effect of valproate on pulmonary cancer cells, in combination with chemotherapy agents.

Neural tube malformations are most common with the use of Valproate, a folic acid antagonist.

Not exact matches

The study helps determine the effects of CBD in combination with common AEDs, including carbamazepine, valproate, levetiracetam, clobazam and lacosamide.

The researchers also evaluated negative symptoms in 43 patients with bipolar disorder, about half of whom were treated with valproate.

The authors conclude that valproate may be effective for treating negative symptoms in psychiatric patients with two copies of the «Val» variant of the COMT gene, which breaks down dopamine in the brain.

The drug — a mood stabilizer called valproate — is commonly prescribed to treat bipolar disorder and schizophrenia, though its mechanism of action is poorly understood and only some patients respond to the treatment.

Of these 171 women, 42 had taken levetiracetam, 27 had taken topirimate and 47 had taken valproate while pregnant — an additional control group of women with similarly - aged children who had not taken any antiepileptic drug while pregnant was also included in the studOf these 171 women, 42 had taken levetiracetam, 27 had taken topirimate and 47 had taken valproate while pregnant — an additional control group of women with similarly - aged children who had not taken any antiepileptic drug while pregnant was also included in the studof women with similarly - aged children who had not taken any antiepileptic drug while pregnant was also included in the study.

Among those patients who were being treated with valproate (approximately one - third of the schizophrenia patients), negative symptoms were more severe in those with the Met / Met gene than in those with the Val / Val gene.

In the roughly 40 percent of patients with this genotype, higher levels of proline (a neuromodulator that is increased by valproate), correlated with fewer negative symptoms.

In patients who have a «Met» variant of COMT, rising levels of proline appeared to do the exact opposite: these patients had more or worse negative symptoms, and the symptoms did not improve with valproate.

Valproate, one of the most commonly prescribed antiepileptic medications, has been associated in the past with birth defects and developmental problems.

Joseph F. Hayes, M.Sc., M.B.Ch.B., of University College London, England, and coauthors compared rates of self - harm, unintentional injury and suicide deaths in patients prescribed lithium, valproate sodium, olanzapine or quetiapine using a large database of electronic health records in the United Kingdom.

The study of 6,671 individuals found lower rates of self - harm and unintentional injuries among those patients taking lithium compared with those prescribed valproate, olanzapine or quetiapine.

A common mood - stabilizing drug, valproate, is found to control manic - like behavior induced in mice with an extra copy of a gene called SHANK3

Because both phenylbutyrate and another weak HDAC inhibitor, valproate, are FDA - approved, clinical trials of these agents started rapidly.

Valproate in the treatment of acute mania.

Valproate increases pro-apoptotic efficacy of chemotherapeutic regimen in small cell lung cancer.

Morland C, Nordengen K, Gundersen V (2012) Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals Neurosci Lett, 527 (2), 100 - 4 PubMed 22963924

Patients taking lithium had lower rates of self - harm and unintentional injury compared to those taking other bipolar drugs, such as valproate (Depacon, Depakote), olanzapine (Zyprexa) or quetiapine (Seroquel), said lead researcher Joseph Hayes.

To compare lithium against newer medications, Hayes and his colleagues collected medical data on nearly 6,700 people diagnosed as bipolar and prescribed only one of the drugs — lithium, valproate, olanzapine or quetiapine.

Of those children, 64 were exposed to valproate in utero, 44 to lamotrigine, 76 to carbamazepine, and 65 to other epilepsy drugs or combinations of drugOf those children, 64 were exposed to valproate in utero, 44 to lamotrigine, 76 to carbamazepine, and 65 to other epilepsy drugs or combinations of drugof drugs.

Compared to children whose mothers did not have epilepsy, the risk of autism was seven times higher in those with valproate exposure.

Alycia Halladay, PhD, the director of research for environmental sciences at Autism Speaks, an advocacy group that raises money for biomedical research, says the study «adds to the growing literature that in utero exposure to [valproate] may be one possible risk factor for autism.»

'' [Then] research can turn to the ways in which women who can not stop or reduce [valproate] treatment while pregnant can ameliorate the risk of birth defects,» Halladay says.

(There was one case of autism each in children exposed to lamotrigine, phenytoin, and a combination of lamotrigine and valproate.)

First line drugs used in the treatment of a migraine include propranolol, topiramate, Divalproex / sodium valproate, and metoprolol.

Ketogenic diet - induced toxicity of the anticonvulsant medication sodium valproate has been reported (30) however these treatments can be used together without problem in most cases (31).

Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode