Future studies are being planned to determine if a higher dose
of Verapamil may be needed to be therapeutic for some patients.
A clinical trial studying the use
of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients.
The presence
of verapamil also decreased the minimum inhibitory concentration of another antimycobacterial drug, clofazimine, against TB.
Not exact matches
New research conducted at the Center for Tuberculosis Research at the Johns Hopkins University School
of Medicine shows that lower doses
of the toxic drug bedaquiline — given together with
verapamil, a medication that's used to treat various heart conditions — can lead to the same antibacterial effects as higher toxic doses
of bedaquiline.
«Using a mouse model
of tuberculosis, we have shown lower doses
of bedaquiline together with
verapamil have the same antibacterial effect as the higher toxic doses,» says Shashank Gupta, Ph.D., a research fellow at Johns Hopkins.
The researchers demonstrated that supplementing bedaquiline with
verapamil profoundly decreased the minimum inhibitory concentration
of bedaquiline against various strains
of TB.
The researchers found that adding
verapamil augmented the potency
of bedaquiline and accelerated its ability to clear mycobacteria in mice.
The clinical trial results, published online in the Journal
of Allergy and Clinical Immunology: In Practice, suggest that
Verapamil represents a promising novel therapy for the treatment
of CRS with nasal polyps.
Motivated by their previous finding
of the presence
of P - glycoprotein overexpression in the nasal lining
of patients with CRS with nasal polyps, the study authors conducted a randomized, double - blind, placebo - controlled clinical trial studying the use
of low - dose
Verapamil in 18 patients with CRS with nasal polyps.
An analysis
of these patients demonstrated improved outcomes for those in the
Verapamil group in relation to those in the placebo group.
These, such as
verapamil, diltiazem, nifedipine, nitrendipine and nimodipine are not only widely used to treat hypertension, and hence might affect cognition by increasing cerebral blood flow, but also block the entry
of calcium ions into neurons.
verapamil) may decrease the effects
of pimobendan If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.
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