Ikaros's function is to bind DNA and regulate the activity
of a large number of genes in cells.
Not exact matches
A
large number of genes involved
in nervous system development and function were also deregulated.
The researchers now are studying some
of the master
genes to determine whether modifying them also causes changes
in large numbers of other
genes.
Correspondingly, a
large number of genes with no direct role
in tumor progression also are deleted as a result
of their proximity to tumor suppressor
genes.
By studying infected cells grown
in a laboratory, the team found that a
large number of CMV's
genes help it hide from the immune system by allowing it to destroy many
of the proteins produced by the body during virus infection and preventing them from activating immune cells to destroy the virus.
1982:
In the early 80s, scientists realize that retroviruses have tremendous potential to deliver
genes stably into
large numbers of cells, and start producing lab - safe versions.
«A study covering a
large number of subjects, like the one
in 2015, makes it possible to identify the relevant
genes across the entire population; but their variations have only a limited impact on individuals.
Pinker says that the findings are a first step
in demonstrating that intelligence relies on
large numbers of genes, each with a tiny effect, rather than on single
genes that have moderate or
large effects, but which are so rare that none has yet been identified.
Although there is no direct test yet, women
in some families with
large numbers of cases can be tested for known genetic markers that are inherited alongside the
gene.
«The idea that you could get a very
large number of complex
genes synthesized and delivered
in a FedEx package is something that was not practical just a decade ago,» says Steve Evans
of Dow AgroSciences.
We identified a
large number of such events
in critical cancer
genes.
But you asked me right, the importance
of gene duplication; most — I say, most, [which] is a rough
number — but a very
large number of the
genes that carry out functions
in our body are parts
of [the] family
of the
genes, members
of [the] family
of the
genes that have expanded by
gene duplication.
Neanderthal genetic material is found
in only small amounts
in the genomes
of modern humans because, after interbreeding, natural selection removed
large numbers of weakly deleterious Neanderthal
gene variants, according to a study by Ivan Juric and colleagues at the University
of California, Davis, published November 8th, 2016
in PLOS Genetics.
A comprehensive genomic analysis
of Wilms tumor — the most common kidney cancer
in children — found genetic mutations involving a
large number of genes that fall into two major categories.
Analyzing
large numbers of cells, each with slight differences
in their DNA, for their ability to carry out a behavior or survive a drug treatment can reveal the importance
of particular
genes, or sections
of genes,
in those abilities.
Participating
in large international research projects, Dr Harbo and colleagues have helped to identify a
number of new risk
genes for MS and MG.
A
large number of rare childhood diseases stem from mutations
in genes that play an essential role
in lipid synthesis.
In particular, the comparison of gene sequences in large numbers of patients and controls will be a key step in strategies for disease gene identificatio
In particular, the comparison
of gene sequences
in large numbers of patients and controls will be a key step in strategies for disease gene identificatio
in large numbers of patients and controls will be a key step
in strategies for disease gene identificatio
in strategies for disease
gene identification.
Now, he and his colleagues are studying
larger numbers of cave fish with variation
in these behaviors,
in the hopes that they can tease out which versions
of which
genes are associated with the extremes
of these behaviors.
«We observed that a
large number of genes were involved
in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages
of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author
of the study.
In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferatio
In particular, the protein enhances the expression
of a well - characterized oncogene called MYC, which
in turn regulates a large number of genes involved in cell proliferatio
in turn regulates a
large number of genes involved
in cell proliferatio
in cell proliferation.
Despite the
large number of identified hearing loss
genes, the cause
of inherited hearing loss remains a mystery
in more than half the children.
While circulating tumor DNA tests targeting a smaller set
of cancer
genes are already available for use
in routine practice to guide care, by covering a much
larger number of cancer
genes, this high - intensity sequencing approach may enable development
of future tests for early detection
of cancer.
In the case
of IGF2BP3 and B - cell leukemia, the overall effect
of the RNA binding protein is to promote the proliferation
of B cells by shifting the expression
of a
large number of genes, Sanford said.
Robert Beall becomes CEO
of the CFF and, grasping the limitations
of gene therapy, invests $ 3.2 million
in Aurora Biosciences Corp., where cell physiologist Paul Negulescu begins to look for a chemical cure using high - throughput methods to test
large numbers of potential drugs.
«When we compared the
gene signature activity
of glioblastoma cells from around 60 patients we found that a
large number of patients could be divided into subgroups that showed a correlation between
gene activity, tumor cell characteristics and cell
of origin similar to the one we had seen
in the mouse study.
The researchers also found epigenetic changes
in a
large number of genes that contribute to reduced insulin production.
The mice seem to develop normally when only one copy
of the
gene is removed, but microscopic inspection reveals a
number of small «gaps,» or disorganized regions
of tissue (on the scale
of a few nanometers) on their aortas, the
largest artery
in their bodies.
In research published today in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukaemic blood cell
In research published today
in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukaemic blood cell
in Cell Reports, the team identify a
large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition
of one
of these
genes, KAT2A, destroys AML cells without harming non-leukaemic blood cells.
«Careful analysis
of the total
number of repeats, the
number of interruptions
in the repeat tract, and the methylation status
of the FMR1
gene is important for a proper understanding
of an individual's risk
of transmission
of larger alleles to their offspring and to their personal risk
of disease pathology.
In one
of the first studies to directly compare the medical records
of a
large number of adults with their Neanderthal - derived DNA, researchers have confirmed that Neandertal
genes have a subtle but significant impact on modern human biology.
Although none
of the German Neolithic samples carries the copy
number expansion
of the AMY2B
gene associated with starch digestion, we find that this
gene is present
in three copies
in NGD, though this is due to a
large segmental duplication that is shared with multiple modern dogs, an event separate from the tandem AMY2B duplications.
Manou Sommen and colleagues report a study
of a targeted resequencing panel for hearing loss was developed including 79
genes for nonsyndromic hearing loss (NSH) L and selected forms
of syndromic hearing loss.They established a straightforward variant classification system to deal with the
large number of variants encountered and showed that after GJB2, the most commonly mutated
genes in a Western - European population are TMC1, MYO15A, and MYO7A.
g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory»,
of the origin
of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,»
of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone
gene gene expression
gene mapping
gene pool
gene therapy
gene transfer General Catalogue
of Variable Stars (GCVS) general precession general theory
of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission
of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost
of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray
Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law
of diffusion Graham's
number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (
in Milky Way) Great Rift Valley Great Square
of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)
«This is the culmination
of years
of work on Alzheimer's disease by a
large number of scientists, yet it is just the beginning
in defining how
genes influence memory and intellectual function as we age.
Study coauthors Rammohan Rao
of the Buck Institute for Research on Aging and Dale Bredesen
of the Buck Institute and UCLA «have provided evidence for a novel —
in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression
of a
large number of genes,» Steven Barger, who studies neurodegenerative disease at the University
of Arkansas for Medical Sciences and was not involved
in the study, wrote
in an email to The Scientist.
The
large number of DNA samples brought together
in this study may enable the researchers to detect
genes whose individual effects
in the disorder may be small but may still play a role.
«It might be difficult to imagine why the
large number of gene variants that together give rise to traits like [autism spectrum disorder] are retained
in human populations,» co-author and genetics and neuroscience professor Joel Gelernter said
in a statement from Yale University.
Large numbers of genes are found
in almost every cell.
Recently, the lab disabled 62
genes (
in a pig genome) all
in one go — the
largest number of simultaneous
gene edits ever accomplished.
At any given instant it can be argued that the cell is
in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated
in space and time, and the complex circuitry — that involves a
large number of interacting networks and a snapshot
of the dynamical processes — such as
gene expression, cell cycle, transport
of components, etc..
«The
larger number of genes in M. pulmonis... can be mainly attributed to an increased
number of membrane proteins,» the researchers write
in Nucleic Acids Research.
Several research groups at Uppsala University participated
in the present study, where they analysed the NF - kB
genes in a
large number of CLL patients.
The revolution
in human genetics has revealed a
large number of genes and pathways associated with these diseases, and emerging methodologies are starting to systematically analyze the cellular and molecular circuitry underlying disease.
These three examples illustrate that there can be
large differences
in morphological complexity among different organisms that have similar
numbers of genes.
The octopus also appears to have a
large number of transposons, or «jumping
genes» that are capable
of rearranging their position
in the genome.
As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the
gene expression profiles
of individual human oocytes and small
numbers of cumulus cells using a combination
of a
large number of samples and targets [12], and then extended our studies via the use
of parthenogenesis,
in conjunction with
gene expression profiling, as a functional assay
of cytoplasmic maturation
of oocytes.
«We found that while hybridisation has not compromised the genetic distinctiveness
of wolf populations, a
large number of wild wolves
in Eurasia carry a small proportion
of gene variants derived from dogs, leading to the ambiguity
of how we define genetically «pure wolves».
His laboratory has also discovered and characterized a significant
number of novel
genes contributing to autism and human neurodevelopmental disorders, and has recently applied whole - genome sequencing technologies and
large - scale genomics datasets to prenatal detection and interpretation
of structural variation
in the genome.
Our results establish
gene conversion as a previously under - appreciated mechanism
of generating copy
number changes
in humans and reveal the exceptionally
large size
of the conversion events that can occur.