The activation
of these particular genes in the body have been seen to burn body fat at such an alarming rate that it is being coined «the cure to obesity».
In many cases, the
activity of particular genes was tied to a single genetic variant, with strong differences in frequency between European and African populations.
They can also estimate how rapidly the DNA
sequence of a particular gene may change, giving a «molecular clock» that puts rough dates next to the tree's branches.
Molecular biologists at Stanford University will analyse DNA from blood samples taken from individuals in those families, looking for as many as 300 markers in the DNA that indicate the
presence of particular genes.
The researchers tag unusual spellings
of a particular gene with short strands of marker DNA linked to a reporter molecule that readily shows up in the microscope.
DM1 (but not Duchennes muscular dystrophy) results from a genetic error that causes expansion of a
region of a particular gene, called DMPK.
Large scientific studies in people and animals may help us understand the
role of particular genes and neurochemicals in this process — and whether this process differs in the various forms of autism.
This study represents the first detailed analysis of DNA methylation
status of a particular gene throughout life, and the results were recently published in Nature Communications.
Differences in the
ability of a particular gene to influence a child's development depending on who it was inherited from, have been seen in a number of disorders, including Huntington's disease and fragile - X syndrome («Why genes have a gender», New Scientist, 22 May 1993).
Laurent Keller at the University of Lausanne in Switzerland and Kenneth Ross at the University of Georgia, Athens, were scanning the genes of various populations of fire ants (Solenopsis invicta) when they noticed something strange: Queen ants who had their own colonies carried two copies of the dominant
variety of a particular gene — they were homozygous for the variety, that is — while those who shared a nest with other queens were heterozygous, carrying only one copy.
Analyzing large numbers of cells, each with slight differences in their DNA, for their ability to carry out a behavior or survive a drug treatment can reveal the
importance of particular genes, or sections of genes, in those abilities.
Kuruvilla's lab group — which has been studying the peripheral nervous system for years — found that
abundance of a particular gene product in Down syndrome puts a brake on NGF's actions in fostering nerve development.
«In other words, access to the genes is determined by the host, but
usage of particular genes is regulated by the microbes,» Crawford said.
Simply replicating a
piece of a particular gene — from one copy in mice to more than 200 in humans — may have prompted some of the changes in the brain that define us as human, according to a new study.
However, when this process goes awry, cancers can arise: damaged DNA or the activation
of particular genes known as «oncogenes» can trigger a cascade of activity that can lead ultimately to unchecked proliferation, the hallmark of a cancer.
Other research at U-M is developing new options for treating brain cancer through immunotherapy — harnessing the immune system to attack cancer cells once an
injection of a particular gene therapy is delivered into the brain tumor.
Comparisons between the nucleotide makeup, or sequence,
of particular genes allows scientists to see how closely they are related, and thus, group the organisms accordingly.
To determine whether
members of a particular gene set were enriched at the top of the list, a Kolmogorov — Smirnov (K - S) running statistic summation was then computed beginning with the top - ranking gene.
The current work shows that changes in the genetic
code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.
A research team led by Masashi Yanagisawa, director of the International Institute for Integrative Sleep Medicine (IIIS) at the University of Tsukuba, believes the differing tendencies could stem from mutations
of particular genes relating to sleep.
«This is the plot twist that gives away the story,» says Sharma, because it allows scientists like him to trace the evolutionary and genetic history of this group of animals, united by their
loss of a particular gene.
Registry parts include operators, which are segments of DNA to which repressor proteins bind to prevent gene transcription; cell - cell signaling elements, which produce defined outputs in response to specific chemical inputs; and riboregulators, which can be used to suppress the expression
of particular genes by preventing translation of proteins they express.
In the past year, biologists have been using the natural form of GFP to track the production of individual proteins or the
activity of particular genes in living cells.
In 2016, the research team spotted mice that sleep for extraordinarily long periods and ones that have extraordinarily short REM sleep in a sample of about 8,000 specimens, and discovered mutations
of particular genes in those mice with unique sleep patterns.
Similarly, someone who inherits the
version of a particular gene that's associated with obesity will be more likely to wind up fat than someone who inherits a normal version, but that tendency can be affected by environmental factors such as how much fattening food is available.
high maternal antenatal stress and perinatal low mood can up - regulate the glucocorticoid receptor gene responsible for HPA activity in their infant, but it is now known that the
presence of particular gene - alleles can heighten the risk (and their absence observed to significantly reduce the risk);
The processes, DNA methylation and histone acetylation, both govern gene expression and can amplify or dampen the
effects of particular genes.
The researchers detected many differences in the activity
of particular genes in those immune cells both within and between populations.
«If you did genomic sequencing,
all of these particular genes would be normal,» Longmore says.
In June, he and his colleague Thaddeus Stappenbeck argued in Nature that all mouse studies should use littermate controls: When studying the activity
of a particular gene, breed mice with and without that gene by starting with heterozygous parents.