Sentences with phrase «of a single gene affects»

Not exact matches

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

The MGH investigators screened the genomes of 40 individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single - nucleotide mutations within the SMCHD1 gene in 84 percent of affected individuals.

«Single gene variation linked to obesity: Variation in the BDNF gene may affect brain's regulation of appetite, study suggests.»

«This treatment takes into account the entire genomic pattern, and shows that affecting a single gene is not enough for the treatment of pancreatic cancer or any cancer type in general,» according to Prof. Satchi - Fainaro.

Changes in the regulatory region of a single gene may have had a profound affect on human evolution.

Silent mutations occur when the change of a single DNA nucleotide within a protein - coding portion of a gene does not affect the sequence of amino acids that make up the gene's protein.

A copy number variant may affect dozens of genes, or it can disrupt or duplicate a single gene.

Studies of worms and fruit flies show that variations, or polymorphisms, in a single gene can affect how long these creatures live.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

Cystic fibrosis, a disease affecting the mucus glands, is just one example of a single - gene disorder.

Our siRNA molecules are designed to target a single mRNA in the cell, only affecting the expression of the disease - causing gene.

RESCUE and REVERSE are two separate randomized, double - masked, sham - controlled pivotal Phase III trials designed to evaluate the efficacy of a single intravitreal injection of GS010 (rAAV2 / 2 - ND 4) in subjects affected by LHON due to the G11778A mutation in the mitochondrial ND4 gene.

Compounded by the fact that a single variant might affect multiple transcripts / genes, the number of observed human coding variants exceeds 22 million.

Expanding our Gene Therapy Initiative is vital to our mission of finding a solution for every single person affected by Duchenne.

Of course, said David Gunn, one of the researchers on the study, there is no single youthfulness gene, and many factors affect how your looks change with age — including genes and lifestylOf course, said David Gunn, one of the researchers on the study, there is no single youthfulness gene, and many factors affect how your looks change with age — including genes and lifestylof the researchers on the study, there is no single youthfulness gene, and many factors affect how your looks change with age — including genes and lifestyle.

Methods.: Dogs of various breeds, affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant of ADAMTS10, as well as 7 other nonsynonymous single nucleotide polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with disease.

It has recently been determined that some herding breeds of dogs have a single mutation in a gene coding for a particular protein (P - glycoprotein) that will drastically affect the absorption, distribution, metabolism, and excretion of a variety of medications used in veterinary medicine.

One mutation, which is complete deletion of the CNGB3 gene, affects Malamutes and Australian Shepherds, while a different single nucleotide mutation in the same gene causes Cone Degeneration in the GSHP breed.

Despite the large number of breeds affected by HC only a single gene, the transcription factor HSF4, has been implicated in the development of cataracts in dogs to date.

AGTC's lead product candidates focus on rare diseases of the eye, caused by mutations in single genes, that significantly affect visual function and currently lack effective medical treatments.