Not exact matches
In yeast, for example, they've found that increasing the activity
of a
single gene,
called Sir2, can significantly extend life span.
Each case can be traced to a bunch
of repeated code letters
of DNA within a
single gene called HTT.
It is caused by a
single gene abnormality which leads to the production
of a mutant form
of a protein
called huntingtin (mHtt).
Such plants have two mutant copies
of a
gene called hothead, which differ from the normal
gene by a
single base pair.
These multigene interactions are subtler and knottier than the
single gene drivers
of diseases such as hemophilia and cystic fibrosis; spotting them
calls for statistical inspiration and rigorous experiments repeated again and again to guard against introducing unproven
gene tests into the clinic.
RNA sequencing
of both
single and clustered CTCs from breast cancer patients identified several
genes expressed at elevated levels in CTC clusters, one
of which — a protein
called plakoglobin — also was overexpressed in the primary tumors
of patients with reduced survival.
The researchers found that the blond hair commonly seen in Northern Europeans is caused by a
single change in the DNA that regulates the expression
of a
gene that encodes a protein
called KITLG, also known as stem cell factor.
Now researchers have identified a
single gene,
called fruitless (fru), as responsible for the development
of male sexual behavior in the fly.
Labs have started tackling the problem with a tool
called single - cell transcriptome analysis, which gives readouts
of all the
genes that are active in individual cells.
Different versions
of genes can vary at
single points in their sequence, and these variations are
called SNPs.
That's unusual; most microbial genomes consist
of a
single chromosome, sometimes with some extra
genes carried on bits
of extraneous DNA
called plasmids.
Overexpressing a
single gene called Arc rejuvenates the visual cortex
of middle - age mice, making them as plastic as younger mice.
The widely accepted RNA - world theory posits that RNA — the molecule that today plays roles in coding, regulating, and expressing
genes — elevated itself from the primordial soup
of amino acids and cosmic chemicals, eventually to give rise first to short proteins
called peptides and then to
single - celled organisms.
Most
of the afflicted family members, but none
of those who sleep normally, carry a
single base - pair mutation in a
gene called hPer2, the researchers report 12 January in a paper published online in Science.
Now two research teams have spotlighted the middle ground, using so -
called gene chips to evaluate millions
of bases
of DNA in a
single experiment.
Your feelings about brussels sprouts could come down to a
single gene: Researchers at the University
of Connecticut found that people missing the receptor for a bitter chemical
called PROP tend to like veggies rich in the compound.
Kuala Lumpur, Malaysia, St. Louis, MO and Cold Spring Harbor, NY — A multinational team
of scientists has identified a
single gene,
called Shell, that regulates yield
of the oil palm tree.
Although mutations come in many varieties, one type,
called nonsense mutations, involve the seemingly innocuous change
of a
single letter in the coded message — a change that causes the
gene's message to prematurely read «stop.»
The researchers discovered a
single letter variant located in TP53, a
gene known to play a central role in tumor biology and for accumulating so
called somatic mutations, during the development
of cancer in patients.
Since then, so -
called Omics technologies have flourished, allowing researchers, for example, to observe and quantify thousands
of gene products in a
single tissue sample.
In findings appearing online today in Cell Stem Cell, researchers in the laboratory
of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a
single gene called Sox2 into both mouse and human skin cells.
Studying a specific type
of genetic variation in the DNA sequences
of wolves and domestic dogs -
called Single Nucleotide Polymorphisms (SNPs)- the scientists identified the transfer
of dog
gene variants into wolf genomes.
We are using a new technique,
called single cell RNA sequencing, to isolate thousands
of single neurons from human brain tissue, study all the
genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.
The technique,
called homologous recombination, allows scientists to remove or insert a specific stretch
of DNA — sometimes even a whole
gene — from a
single cell.
Lloyd Trotman's recent research path begins at his discovery some years ago that the loss
of a
single copy
of a master tumor suppressing
gene called PTEN is sufficient to permit tumors to develop in animal models
of prostate cancer.
Malaria infections that were slow to clear were also strongly associated with a
single - point mutation in a P. falciparum
gene called kelch 13, an important validation
of the recently discovered genetic marker (k13) in the DNA
of the malaria parasite.