At the core of this cell behavior is how the loss
of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.
Around 2.5 million years ago, the erroneous duplication
of a single gene changed the course of our brains» evolution forever.
The unintended consequence
of a single gene change pale in comparison to the negative health consequences of the intensive inbreeding required to produce the extreme physical features of the fad breeds of today.
Not exact matches
Alpha -1-antitrypsin deficiency (A1ATD) is the most common genetic disease
of the liver, and is caused by a
single nucleotide
change in the
gene that codes for alpha -1-antitrypsin (A1AT), an enzyme inhibitor that normally protects bodily tissues.
To generate the models, Jackson created two mutated versions
of the PrP - coding
gene by
changing a
single codon — one
of the three - nucleotide «words» in
genes that code for the various amino acids in proteins.
The team found that a mutation in a
single pair
of nucleotides in the
gene causes seed coat permeability — that is, a
change in one pair out
of the approximately 1 billion base pairs that make up the soybean genome.
Cystic fibrosis, achondroplasia, phenylketonuria and Huntington's disease are each caused by simple
changes in the sequence
of a
single gene.
According to study co-author Larry J. Young
of Emory University, the results provide evidence in a comparatively simple animal model that
changes in the activity
of a
single gene profoundly can
change a fundamental social behavior
of animals within a species.
The researchers found that the blond hair commonly seen in Northern Europeans is caused by a
single change in the DNA that regulates the expression
of a
gene that encodes a protein called KITLG, also known as stem cell factor.
After analyzing brain tissue samples, the researchers identified an area
of the
gene where a
single change reduced BDNF levels in the hypothalamus, a key area that controls eating and body weight.
The genomics era has had a profound impact on life science research, leading to significant developments such as the use
of expression quantitative trait loci (eQTLs), which link polymorphisms in
single genes to quantifiable
changes in
gene expression associated with specific diseases.
«Our work clearly shows that predisposition to obesity and increased body mass index is not due to a
single gene or genetic
change,» says senior study author Elizabeth Speliotes, M.D., Ph.D., M.P.H, assistant professor
of internal medicine and computational medicine and bioinformatics at the University
of Michigan Health System.
Hereditary predisposition to cancer is sometimes due to a
single high - risk genetic
change, like a mutation in the BRCA1 or BRCA2
genes for breast cancer, but most
of the time, the disease is the result
of multiple
gene variants that add up, environmental risk factors, and a big element
of chance.
«For species that have a very rapidly
changing environment, this process
of co-option
of single genes may be fairly important.
Gene moonlighting can occur merely through
changes in expression, which may result from as little as a
single mutation; it does not require the meandering process
of random alteration and selection implied by the duplication and neofunctionalization model.
An alteration in the neuregulin - 1
gene — a
single change in one letter
of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.
Brandis and Hughes
changed many different codons and showed that
changing even a
single codon in the
gene for this protein into any one
of the alternative «synonymous» codons reduced the «fitness»
of Salmonella.
In a sign
of the method's power, Pritchard's team also detected selection in traits controlled not by a
single gene, but by tiny
changes in hundreds
of genes.
Researchers say that each progeria case arises randomly due to a
single letter
change in one
gene of the child's DNA.
Further analysis revealed that a
single - letter
change in the
gene accounted for 46 per cent
of the population's hair colour variation, with the blonde allele being recessive to the dark hair allele.
Typically, genome analysis studies primarily look for
single changes — one altered unit
of DNA — not wholesale copying or halving
of genes.
PENCIL IT IN Scientists have used two new versions
of CRISPR
gene editors, which rewrite DNA like pencils instead
of cutting like scissors, to
change single - letter typos that cause some blood disorders.
This
single cell transcriptome analysis followed by computational analyses enabled the team to identify the
gene expression profiles
of cells in the process
of changing from ES cells to 2CLCs.
Changing the epigenetic code
of a
single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to research by Queen Mary University
of London (QMUL).
Changes in the regulatory region
of a
single gene may have had a profound affect on human evolution.
Silent mutations occur when the
change of a
single DNA nucleotide within a protein - coding portion
of a
gene does not affect the sequence
of amino acids that make up the
gene's protein.
Technological advances in genetic analysis have uncovered
changes in
single genes that account for a surprising number
of infantile and early - childhood epilepsies.
Although mutations come in many varieties, one type, called nonsense mutations, involve the seemingly innocuous
change of a
single letter in the coded message — a
change that causes the
gene's message to prematurely read «stop.»
Carrying two copies
of a
single - letter
change in the DNA
of chromosome 16 led to a 35 per cent increase in activity
of the
gene GSPT1 ¬ in men with testicular cancer, compared with those without.
The results also showed that polymorphism, a genetic variant that can
change the way a particular
gene functions, is possible under a wide range
of conditions, which results in a
single population playing a variety
of different behavioral games.
This, in my opinion, is one
of the most compelling parts
of this study: in vivo functional validation
of a
single base
change in a noncoding enhancer that's hundreds
of thousands
of bases away from the
gene it regulates.
The most radical news at the conference was the first reported use
of CRISPR / Cas9 to generate precise genome edits (
changing only a
single base pair) in two
genes, not only in cell lines in vitro, but also in specific tissues
of embryos in ovo.
Many individual ASD patients had deletions or duplications
of multiple
genes within this network, but for those patients with just a
single gene from the network
changed, that
single gene appeared to play an important role.
Using
gene sequencing, the researchers learned that every member
of the family with congenital heart disease had the same mutation in GATA4 — a
change in a
single letter in the
gene.
Howard Hughes Medical Institute researchers have discovered that a
gene commonly mutated in a wide range
of cancers can
single - handedly trigger pre-cancerous
changes in cells.
July 3, 2013 New mechanism for human
gene expression discovered In a study that could
change the way scientists view the process
of protein production in humans, University
of Chicago researchers have found a
single gene that encodes two separate proteins from the same sequence
of messenger RNA.
To avoid these problems, the team used sequence data to create a list
of single DNA letter
changes, known as SNPs, which can be reliably identified in the
gene - rich areas
of the genome.
Using this technology, we screened 31 patient samples across an array containing a total
of 162 exons for five disease
genes and detected copy - number
changes, ranging from whole -
gene deletions and duplications to
single - exon deletions and duplications, in 100 %
of the cases.
However, although CRISPR / Cas is currently good at
changing single letters in DNA, it can not yet specifically target the expanded
gene and reduce the number
of CAG repeats.
A
single disabling
change — an alteration
of one nucleotide — was found in the TRAPPC9
gene in all three girls.
First, Dr. Shendure described some interesting experiments under way in his lab to elucidate the function
of non-coding regulatory variants — specifically,
single nucleotide
changes in the core promoter that alter
gene transcription.
No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a
single significant
gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion
of the population, perhaps by increased symmetric self - renewal
of the CSC or de-differentiation
of early progenitor cells, rather than simply the acquisition
of anoikis resistance in non-CSC.
For example, studies have shown that when a
single bacterium becomes part
of a biofilm the expression
of over 800
genes can
change.
Of course, said David Gunn, one of the researchers on the study, there is no single youthfulness gene, and many factors affect how your looks change with age — including genes and lifestyl
Of course, said David Gunn, one
of the researchers on the study, there is no single youthfulness gene, and many factors affect how your looks change with age — including genes and lifestyl
of the researchers on the study, there is no
single youthfulness
gene, and many factors affect how your looks
change with age — including
genes and lifestyle.