Sentences with phrase «of a stem cell niche»

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

This research provides new insights into the structure of the stem cell niche in health and after injury.

Abd - B is essential for the positioning and function of the stem cell niche.

The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.

Characterization of functional potency and description of stem cell niches.

Title: What does the concept of the stem cell niche really mean today?

I am a glycobiologist currently working to develop biomaterials that can be used to mimic the role of the stem cell niche.

It is further proposed here that blockage of stem cell niches by senescent stem cells may account for some of the functional alterations observed in stem cell compartments at old age.

In an earlier study, Jones had shown that the hub cells secrete the self - renewal factor upd, which signals neighboring stem cells to maintain stem cell fate, making hub cells an essential component of the stem cell niche.

Not exact matches

Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell - intrinsic mechanism.

Not only the root's stem - cell niche is located there, the root tip also accommodates sensors for an auxin - dependent growth of the plant based on gravitation.

Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

«We believe that our experiments provide the first example of a factor that both expands the intestinal stem cell compartment and builds a niche.»

From the French word nicher, which means to build a nest, a niche is a nest - like compartment comprised of cells that secrete growth factors and other proteins that help stem cells survive.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.

The niche prevents stem cells from being depleted, while protecting the body from over-production of stem cells.

Understanding stem cell niches is therefore important in the field of stem cell therapeutics.

«We don't yet know if this type of coordination and control works in stem cell niches of other tissue types,» says DiNardo.

Where the concentration of WOX5 is high enough, the stem cell niche is able to maintain the pluripotent stem cells.

HSCs are a type of adult stem cell that live in little niches in the bone marrow.

Stem cell populations reside in areas called niches deep within different types of organs.

Stephen DiNardo, PhD, a professor of Cell and Developmental Biology and Kari F. Lenhart, PhD, a postdoctoral scientist in the DiNardo lab, study the development of fruit fly sperm as a model to investigate the stem cell - niCell and Developmental Biology and Kari F. Lenhart, PhD, a postdoctoral scientist in the DiNardo lab, study the development of fruit fly sperm as a model to investigate the stem cell - nicell - niche.

But how the production of daughter cells from the different stem cell types is coordinated within a single niche is virtually unknown.

In this case, the niche residing at the tip of the testis is the site of stem cell divisions, which are critical to produce daughter cells that later become sperm.

What's more, the timing of that separation is controlled by neighboring stem cells in the niche.

In addition, many niches contain different stem cell types, each necessary to produce the distinct types of cells needed for tissue renewal.

«LEVER 3 - D is amazing, it opens new vistas for understanding the stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2stem cell research since 2cell research since 2005.

This striking finding shows that regulation of cytokinesis is how this niche coordinately produces daughter cells from different stem cell types.

Engineering a megakaryocyte niche (a special environment in which stem cells live and renew) that supports the growth of hematopoietic stem cells in culture, is the next step for the researchers.

He is known for showing how niches of neural stem cells constantly regenerate parts of the rodent brain.

The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

In the breast, the ducts designed to carry milk during and after pregnancy are composed of two highly specialized cell types and a niche of stem cells that gives rise to both types.

This Registered report describes the proposed replication plan of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).

In turn, the niche cells control the production and also the differentiation of the blood stem cells.

Such a depot or niche of endothelial stem - like cells would be analogous to the epithelial stem cells located in the anterior limbus that supply cells to the basal epithelium as transient amplifying cells, the cells that become committed to the state of terminal differentiation [11,15].

However, when coupled with the observation that induced eyes continued to grow throughout the life of the animals (Figure 4D and 4H), these results suggest EFTF - induced eyes contain a self - renewing population of retinal cells in the retinal stem cell niche of the CMZ.

Determining the effect (s) of these extrinsic factors on induced retinal cells and the formation of the CMZ in induced eyes will help define the molecular mechanisms regulating the formation and maintenance of retinal stem cells and the niche in which they reside.

Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche.

While it is generally accepted that MSC are mostly quiescent during postnatal life, MSCs in different niches can presumably differentiate into the specific cells of closely related niches during physiological turnover, injury or disease, as shown for other stem cell types (e.g., muscle satellite cells).

«Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long - term maintenance and generation of functional cells through augmented stem cell competition.»

He explains that this creates a new «niche» of neural stem cells, and they appear to be functioning well.

To culture embryonic stem cells on LN521 enables easy and efficient expansion of your hESCs and iPSCs and provides a biorelevant in vitro stem cell niche.

In roots, BRs promote division of quiescent center (QC) cells at the root stem cell niche (González - García et al., 2011; Heyman et al., 2013).

Cost - effective creation of biofunctionalised scaffolds, tailored to function as stem cell niches for expansion, transport and delivery.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

«Niche Control Of Stem Cell Function.»