This abnormality can lead to development
of abnormal cartilage, and eventually create a loose flap of cartilage within the joint.
Osteochondrosis dessicans (OCD) is a condition
of abnormal cartilage growth seen in rapidly growing dogs.
Not exact matches
Investigators at Duke University, led by Erica Davis, PhD, a co-senior author
of the report, blocked the gene's expression in zebrafish, which resulted in
abnormal facial
cartilage, smaller eyes and structural abnormalities
of neurons involved in the development
of reproductive organs.
Other structural problems caused by inheritance are elbow dysplasia, dwarfism, osteochondrosis (
abnormal formation
of bone and
cartilage), spinal disc diseases, Legg - Perthes disease (a hip malformation occurring mostly in small breeds), and patellar luxation (loose kneecap).
As
cartilage degenerates it becomes more fragile and susceptible to injury as a result
of the
abnormal shearing forces exerted on the now unstable joint.
It is also seen more commonly in small breed dogs with other disorders
of cartilage formation and growth, suggesting that the mechanism may involve
abnormal growth or degeneration
of the connective tissue components
of the valve leaflets.
Hip dysplasia is a result
of abnormal wear
of the hip
cartilage.
Osteochondrosis: a group
of developmental diseases resulting in
abnormal formulation
of joint
cartilage.
Achondroplasia:
abnormal development
of cartilage leading to dwarfism (seen aberrantly in most breeds, but that's what makes a Basset hound and other achondroplastic breeds long and low).
In others
abnormal stresses or trauma to the joint can cause degeneration
of the joint
cartilage and underlying bone.
If your Havanese shows signs
of patellar luxation early in life, the major muscle groups
of the thigh pull toward the inside
of the leg, putting
abnormal pressure on the knee joint
cartilage.
Although short legs are normal for these breeds it is basically the result
of abnormal development
of cartilage.
The result
of the instability in the joint is
abnormal wear
of the
cartilage.
Osteochondritis Dissecans or OCD is a serious joint disease in which
abnormal development
of cartilage occurs.
Recent studies have linked osteoarthritis occurrence and progression with an
abnormal response
of the immune system to exposed
cartilage proteins.
This condition affects the weight - bearing joints (hips, knees, elbows, shoulders), causing loss
of lubricating fluids, wearing away
of cartilage, and
abnormal bone growth.
Osteochondrosis (OC [D]-RRB--- improper blood supply to a small section
of the humerus within the elbow joint leaving an
abnormal section
of cartilage that may break free in the joint;
These theories include failure
of transition
of cartilage to bone during development, and excessive wear and tear on the coronoid process due to joint incongruity which places
abnormal stresses on the developing bone.
The term osteochondrosis refers to an
abnormal development
of the
cartilage on the end
of a bone in the joint, while osteochondritis dissecans refers to a separation
of the diseased
cartilage from the underlying bone.
If left undiagnosed and untreated, this instability causes
abnormal wear
of the hip
cartilage and ultimately progresses to osteoarthritis or degenerative joint disease.
Surgery is the treatment
of choice for this condition, and its aim is to remove any
abnormal cartilage or bone and attempt to return the joint to a more normal anatomy and function.
The initiating events that trigger the inflammatory cascade usually fall into one
of two categories, either: 1)
abnormal forces imposed on normal joints such as fractures, sprains, obesity, direct trauma, etc.; or 2) normal forces imposed on
abnormal joints such as elbow or hip dysplasia, osteochondrosis dissecans (OCD), patellar luxation, ununited anchoneal process, fragmented coronoid process, cranial cruciate ligament rupture or tear, and other congenital or genetic conformational
cartilage, bone or joint defects.
This
abnormal displacement
of the kneecap results in pain,
cartilage damage, and arthritis.
More precisely the different joint conditions grouped under the name
of elbow dysplasia include: a ununited anconeal process (failure
of union between the anconeal process and the remainder
of the ulna beyond 20 weeks
of age), the so - called osteochondrosis dissecans
of the humeral condyle (failure
of ossification
of the articular
cartilage covering the humeral condyle, resulting in an
abnormal thickening
of the articular
cartilage and separation between this region and the underlying bone), and finally the fragmentation
of the coronoid process (in which the ulnar coronoid process have multiple fragments or most often a single fragment).
Hip dysplasia is painful in young dogs because
abnormal wear
of joint
cartilage exposes pain fibers in underlying bone and laxity causes stretching
of surrounding soft tissues.
Abnormal development
of the hip causes excessive wear
of the joint
cartilage during weight bearing, eventually leading to the development
of arthritis, often called degenerative joint disease (DJD) or osteoarthritis (OA).
OCD (osteochondrosis dessicans) can also be treated surgically by removing the
abnormal piece
of cartilage with a good prognosis for resolution
of lameness.
This technique involves removing the femoral portion
of the hip joint (i.e., the ball) to reduce the pain produced by
abnormal hip joint contact that wears away the joint
cartilage, and the stretching
of the soft tissues around the joint due to laxity (Figure 5).
This medial sliding
of the patella puts
abnormal forces on the bones and muscles
of the leg, causing progressive deterioration
of the
cartilage in the knee joint and eventual arthritis.
The resulting mechanical looseness
of the joint (hip laxity or subluxation) causes
abnormal wear on the
cartilage that line the femoral head.