Sentences with phrase «of abnormal chromosomes»

«The authors went on to study the resulting blastocysts for aneuploidy (frequency of abnormal chromosomes), and pattern of gene expression (which genes are active and at what level).

Embryos can also be affected by complex combinations of abnormal chromosomes, and even contain an extra entire set of chromosomes (triploidy).

Diversity and abundance of the Abnormal chromosome 10 meiotic drive complex in Zea mays % U http://arxiv.org/abs/1209.5466.

Diversity and abundance of the abnormal chromosome 10 meiotic drive complex in Zea mays.

Not exact matches

But it also might be chromosome number two, and so if you have an abnormal amount of chromosome number two, and then the sperm comes in and meets it you either have only one or you might have three.

Some researchers have even looked at the chromosomes of the miscarried pregnancy to determine whether the NK cells were elevated because of the body's natural response to a chromosomally abnormal pregnancy.

An embryo that carries an abnormal number of chromosomes is «aneuploid».

That's because D7 embryos — which develop more slowly — are thought more likely to contain an abnormal number of chromosomes (aneuploidy).

In Cooper's lab, Godinho Ferreira worked to understand why telomeres function differently than deleterious chromosome ends generated by the abnormal breaking of chromosomes.

«One of the main causes of female infertility is a defect in the eggs that causes them to have an abnormal number of chromosomes.

Many tumors are characterized by «aneuploidy,» meaning they display an abnormal number of chromosomes and chromosomal segments.

Previous research suggests sperm with an abnormal amount of chromosomes may lead to failed pregnancies and birth defects.

Abnormal number of chromosomes is often associated with cancer development.

An oocyte with decreased Topoiosmerase II levels in heterochromatic region of the X chromosome (green) failed to separate while heterochromatic region of the 4th chromosome (red) is stretched into abnormal projections.

«They have abnormal numbers of chromosomes, and they would develop abnormally, and so you can't use them.

Then she learned that people with 22q duplication — abnormal repetition, or duplication, of genetic material in chromosome 22 — had learning delays and sometimes autism, but a lower risk for schizophrenia than that found in the general population.

The discovery might also apply to cancer, because cancer cells often have abnormal numbers and arrangements of chromosomes.

As with most cancers, triple - negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with abnormal numbers of chromosomes.

Aneuploidy is a condition in which cells contain an abnormal number of chromosomes, and is known to be the cause of many types of cancer and genetic disorders, including Down Syndrome.

The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return — treatment failure.

UroSEEK uses urine samples to seek out mutations in 11 genes or the presence of abnormal numbers of chromosomes that would indicate the presence of DNA associated with bladder cancer or upper tract urothelial cancer (UTUC).

One must have had an abnormal egg or sperm that retained two copies of its chromosomes instead of the usual single set that is in such germ cells, Lyko explains.

Zhou and his team said reversing the abnormal activity of the inactive X chromosome in patients suffering from mental illness may offer a potential new strategy for treating psychiatric disorders.

For more than 100 years, researchers have been unable to explain why cancer cells contain abnormal numbers of chromosomes, a phenomenon known as aneuploidy.

For some inexplicable reason, the chromosomes in 40 % of the eggs looked abnormal — a wild jump from the 1 % to 2 % abnormality her lab typically observes.

In 1914, German biologist Theodor Boveri postulated that abnormal chromosome number, or aneuploidy, might be a root cause of cancer.

According to Reeves, the result suggests that genes in the DSCR make their mischief by interacting with other abnormal genes far away on chromosome 21, and that the genetics of Down syndrome are probably more complex than has been generally thought.

Down Syndrome belongs to the group of conditions called «aneuploidies», defined by an abnormal loss or gain of genetic material, i.e. fragments of chromosomes or whole chromosomes.

Aneuploidy (an abnormal number of chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).

«In fact, abnormal cells with numerical and / or structural anomalies of chromosomes have been observed in as many as 80 - 90 % of human early stage embryos following in vitro fertilization,» says Professor Thierry Voet from the Wellcome Trust Sanger Institute, UK, and the University of Leuven, Belgium, another senior author of this paper, «and CSV tests may expose some degree of these abnormalities.»

His focus shifted to the abnormal number of chromosomes that virtually every cancer tumor has — an observation first made by German scientist Theodor Boveri in the early 20th century.

A genetic test examines a DNA sample of a person's cells for abnormal genes, or analyzes the number, arrangement and characteristics of the chromosomes.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

How do meiocytes recognize if chromosome pairing fails, how do they correct such errors, and how defective meiocytes are eliminated, in order to avoid the formation of gametes with aneuploidy / abnormal genomes?

However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage.

We are particularly interested in the mechanism of chromosome pairing and the quality control of the crossover formation process, and we aim to understand how the formation of gametes with abnormal / aneuploid genome is minimized in mammals.

If the test result is abnormal (the tissue has an abnormal number of chromosomes), its good news.