UroSEEK uses urine samples to seek out mutations in 11 genes or the presence
of abnormal numbers of chromosomes that would indicate the presence of DNA associated with bladder cancer or upper tract urothelial cancer (UTUC).
Not exact matches
But it also might be
chromosome number two, and so if you have an
abnormal amount
of chromosome number two, and then the sperm comes in and meets it you either have only one or you might have three.
An embryo that carries an
abnormal number of chromosomes is «aneuploid».
That's because D7 embryos — which develop more slowly — are thought more likely to contain an
abnormal number of chromosomes (aneuploidy).
«One
of the main causes
of female infertility is a defect in the eggs that causes them to have an
abnormal number of chromosomes.
Many tumors are characterized by «aneuploidy,» meaning they display an
abnormal number of chromosomes and chromosomal segments.
Abnormal number of chromosomes is often associated with cancer development.
«They have
abnormal numbers of chromosomes, and they would develop abnormally, and so you can't use them.
The discovery might also apply to cancer, because cancer cells often have
abnormal numbers and arrangements
of chromosomes.
As with most cancers, triple - negative breast cancer (TNBC) cells have
abnormal amounts
of chromosomes or DNA copy
number aberrations (CNAs) in their genomes.
Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with
abnormal numbers of chromosomes.
Aneuploidy is a condition in which cells contain an
abnormal number of chromosomes, and is known to be the cause
of many types
of cancer and genetic disorders, including Down Syndrome.
For more than 100 years, researchers have been unable to explain why cancer cells contain
abnormal numbers of chromosomes, a phenomenon known as aneuploidy.
In 1914, German biologist Theodor Boveri postulated that
abnormal chromosome number, or aneuploidy, might be a root cause
of cancer.
Aneuploidy (an
abnormal number of chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).
His focus shifted to the
abnormal number of chromosomes that virtually every cancer tumor has — an observation first made by German scientist Theodor Boveri in the early 20th century.
A genetic test examines a DNA sample
of a person's cells for
abnormal genes, or analyzes the
number, arrangement and characteristics
of the
chromosomes.
Moreover, many human tumors have highly
abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps
of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic
of advance tumors thought to drive acquisition
of malignant growth properties.??
If the test result is
abnormal (the tissue has an
abnormal number of chromosomes), its good news.