Sentences with phrase «of abnormal protein»

Alzheimer's Disease involves the accumulation of abnormal protein — either amyloid beta or Tau protein which gums up the brain system.

Scientists have identified a basic pathologic process underlying Alzheimer's development that involves the formation of abnormal protein deposits in the brain known as beta - amyloid plaques, but they still aren't entirely sure what causes this to happen.

But this is the first study to show how lifestyle factors directly influence levels of abnormal protein deposits in the brain that have been long tied to Alzheimer's disease.

Deep inside the brains of people with dementia and Lou Gehrig's disease, globs of abnormal protein gum up the inner workings of brain cells — dooming them to an early death.

Howard Hughes Medical Institute researchers have provided the first detailed look at the core structure of the abnormal protein filaments found in at least 20 devastating diseases, ranging from...

In most cases, CTE is thought to be caused by repeated blows to the head, which damage brain tissue and lead to a buildup of an abnormal protein called tau, according to the CTE Center.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

LM22A - 4 treatment reduced the accumulation of abnormal proteins in the striatum and cortex — brain regions affected in Huntington's disease.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

«How nerve cells are damaged by accumulation of abnormal proteins.»

In cancer cells, the drugs produce a substantial increase in the display of abnormal proteins on the cells» surface.

By combining pieces of different genes, fusion genes can lead to production of abnormal proteins that disrupt cell function.

In thyroid cancer in dogs caused by parafocllicular cells can cause diarrhea resulting from the production of abnormal proteins in the C - cells.

Not exact matches

The cancerous cells win out over the healthy blood cells in the bone marrow, which in turn leads to kidney problems when the cancer cells make abnormal proteins instead of antibodies.

Food allergens are typically naturally - occurring proteins in foods or derivatives of them that cause abnormal immune responses.

Whey protein may cause abnormal heart rhythms, changes in cholesterol levels, headache, increased diabetes risk, increased fracture or osteoporosis risk, kidney dysfunction, liver damage, stomach or intestine symptoms (acid reflux, bloating, constipation, cramps, gas, increased bowel movements, movement problems, nausea, reduced appetite, swelling of limbs, and upset stomach), and thirst.

In an interview, the Glasgow - based neurologist described how he had examined sections of brain tissue in a retired rugby player and found abnormal proteins associated with head injuries and dementia.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

The researchers worked through the symptoms of the disease, matching each one with abnormal levels of proteins from the biopsies, and then with existing drugs that could potentially provide relief.

A study of 32,000 appendixes removed between 2000 and 2012 from British people born between 1941 and 1985 suggests that 1 in every 2000 people in the UK is carrying the abnormal protein, or prion, that causes the disease.

All these diseases share a common feature: abnormal buildup of a protein called tau in the brains of patients.

All of these mutations destabilize the protein's normal structure and promote abnormal SOD1 structures.

At the Gladstone, cardiovascular scientist Robert Mahley, working with a team including neuroscientist Yadong Huang, has identified small «corrector» molecules that modify the structure of ApoE4 protein to one more like that of ApoE3, thereby reducing abnormal fragmentation.

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

The team's key discovery was that stem cells lacking an enzyme responsible for pseudouridine modification of RNA, known as PUS7, produce abnormal amounts of protein.

Two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease.

People with the transthyretin amyloidosis have mutations in the DNA of the transthyretin gene, which causes abnormal buildup and deposits of a transport protein called transthyretin in nerve and heart cells.

The researchers have now provided further evidence for this new theory by showing that the abnormal protein coded for this genetic disorder can be transmitted to normal animals by the injection of diseased cells into their brain.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

Liu notes that this abnormal protein secretion occurs in other parts of the body as well with exfoliation syndrome, but appears to be problematic only in the eye.

FA is caused by reduced expression of a mitochondrial protein called frataxin (FXN) due to a two mutated or abnormal copies of the FXN gene.

Coeliac disease is caused by an abnormal reaction to gliadin, a gluten protein found in wheat (and similar proteins of the tribe Triticeae which includes other cultivars such as barley and rye).

The Chilean Rose Tarantula is the source of an important protein used in drugs to stop atrial fibrillation, an abnormal heart rhythm, or cardiac arrhythmia, which can result in death.

According to the proposal, called the amyloid hypothesis, Alzheimer's disease, estimated to affect more than 5 million people in the United States alone, is caused by abnormal buildup of A-beta protein in the brain.

In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of toxic abnormal immunoglobulin called monoclonal protein that can damage multiple organs.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

They also expressed abnormal levels of proteins involved in neurodegenerative conditions.

Other approaches target the abnormal accumulation of the protein tau in neurofibrillary tangles.

National Institutes of Health (NIH) scientists and collaborators at Case Western Reserve University School of Medicine have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt - Jakob disease (CJD).

Arising from the abnormal buildup of a protein known as alpha - synuclein in the brain, such conditions damage the nerves that control blood pressure and heart rate.

Plants grown from these cells make abnormal versions of messenger RNA, the molecule used to make the proteins.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

Several of the proteins characteristic of cancer cells seem to show up in these nerve cells, and this is very abnormal.

In earlier studies, Ruggero found that myc not only drives protein production, but also that myc - driven cancer cells become absolutely dependent upon this ability to make abnormal amounts of protein.

Trouble begins when they misfold into abnormal versions of the protein.

«Too little of this protein disrupts normal stem cell function, but too much can promote abnormal growth and lead to cancer.

Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicalOf particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicalof gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicals.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.