Sentences with phrase «of actin»

Her laboratory focuses on the roles of the actin cytoskeleton in cell architecture and physiology in organs such as muscle, blood and eyes.

Growth of lamellar networks of actin filaments after the addition of the new compounds (compare the cell contours on the left and right).

In addition, they have identified the growth mechanism of the actin network by comparative in vivo and in vitro studies in order to ensure the validity of the process.

STED nanoscopy of actin dynamics in synapses deep inside living brain slices.

Role of actin cytoskeleton in cell migration.

The authors found that a mutant form of actin impairs the ability of INO80 to function correctly, implicating nuclear actin in the process of chromatin remodeling - a mechanism that helps regulate the expression of genes.

Bardet - Biedl syndrome proteins control the cilia length through regulation of actin polymerization.

This signaling starts polymerization of actin, the structural protein inside the cell, causing the formation of a protrusion known as a «pseudopod» in the direction of the gradient, and blocks receptors on the tail end of the cell in what is known as global inhibition.

A ring composed of actin filaments and myosin motor proteins pinches the cell apart, producing two daughter cells with equal amounts of cellular components.

The gene discovered in the research couples the exocytosis - regulating protein Sec10 with formin, a protein that regulates the remodeling of the actin cytoskeleton critical to forming cell shapes.

In contrast, injection of bacterial cells of the insect pathogen Photorhabdus leads to a rapid «freezing» phenotype of the hemocytes associated with significant rearrangement of the actin cytoskeleton.

Using high - resolution «nano - tracking», we discovered that Listeria moves with step - like motions and the steps are the size of the actin monomers used to construct tails.

The scientists propose that Src42A — a protein that belongs to the family of kinases that regulates the structure of the actin filament — is one of the main contributors to this system.

This is the first time that a pharmacological tool induces growth of the actin network — something that living organisms do all the time.

She wrote her dissertation on pollen sterility in petunias, but she also studied cell structure, which led her back to animals and a postdoc at the Scripps Research Institute in San Diego, California, where she studied a protein on the ends of actin filaments.

The scientists tracked the cytoskeletons of endothelial cells as they were crossed by immune cells in real time, the behavior of the nuclei of various white blood cells during active squeezing, and the fate of the various types of actin fibers that make up the endothelial cell skeletons.

However, the structure revealed to be more than the sum of its parts: placing two diametrically opposing α - actinin molecules does not only allow simultaneous binding of actin and titin filaments and so anchoring them in the Z - disc, but also confers regulation.

Further, they linked the chemical reactions of the different molecules to the reorganization of the actin cytoskeleton, which gives the cell its shape.

In this study, the mechanisms of actin - bundling in filopodia were examined.

2007 Selection of research article, «Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle,» published in Proceedings of National Academy of Sciences USA, by Faculty of 1000 Biology, which comprehensively and systematically highlights and reviews the most interesting papers published in the biological sciences, based on the recommendations of a faculty of well over 2,300 selected leading researchers.

Here, we investigate the mechanical properties of actin bundles in the absence of cross-linkers.

Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator of actin cytoskeleton dynamics (i.e. the inner structural support of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel growth), inflammation, and fibrosis (thickening and scarring of tissue) associated with choroidal neovascularization (CNV) in wet AMD.

In addition, breast cancer cells respond differently to S1P in terms of the regulation of actin cytoskeletal structures.

It requires cell migration, which is driven by the polymerisation of actin within two distinct structures, lamellipodia and filopodia, and attachment to the extracellular matrix through actin - rich adhesive structures.

Aside from the variation of paracrine factors between male and female cells, the team also found important differences in organization, distribution and morphology of actin filaments in male and female hAMSCs.

«If we destroy the cytoskeleton but do not allow the actin to enter the nucleus, the little bits of actin just sit in the cytoplasm, and the stem cells do not become bone cells.»

In the lung cancer cell shown above at left, red shades indicate the presence of actin, a structural protein important in cell movement.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

When the actin polymerization occurs at one spot on the surface of an autophagosome, which coincides with the location of WHAMM on these organelles, an actin comet tail is formed, and the rapid assembly / disassembly of the actin polymers «pushes» the autophagosome toward the lysosome for final processing.

The constant assembling and disassembling of actin comet tails on the surface of autophagosomes makes them move with speeds of approximately 0.5 micrometers per second.

The Penn scientists have visualized this phenomenon at high resolution in live cells, revealing the formation of actin «comet tails» that propel the formation and movement of autophagosomes from the ER membrane.

«Sarcomeres are mainly made up of actin and myosin protein strands called filaments.

In this way, they uncovered the mechanism which determines the functional characteristics of actin filaments in all cells and orchestrates cellular activity.

Migrating cells are known to form dynamic protrusions at their leading edge, but the function of these actin - rich protrusions has remained elusive.

A protein complex known as ARP2 / 3 controls the production and distribution of actin in the cell and directs traffic along these roadways from its position at the tip of the trichome.

Here, in fission yeast the actin ring was found to be required to generate late - mitotic microtubular structures located at the division plane, and these in turn maintained the medial position of the actin ring.

It also forms a meshwork of actin that can influence the behavior and organization of the rest of the cell.

Then, according to Mothes, «viruses «surf» along filopodia to efficiently infect cells by using the underlying retrograde flow of actin.»

The microscopy image shows a section of a human mid-gestation placental chorionic villi that has been stained to visualize localization of actin (red) and cell nuclei (blue).

Steps are completely unexpected and shatter prior models of actin - based motility (see link for animations of models).

Since the viscosity of actin solution increases due to polymerization, the rate was accessible.