Sentences with phrase «of actin bundles»
Here, we investigate the mechanical properties of actin bundles in the absence of cross-linkers.
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Actin allows vital actions to be performed by assembling and disassembling itself spontaneously, continually and rapidly in the form of filaments that organize themselves and form networks of parallel bundles or intertwined meshes (known as lamellar networks).
Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly.
The switch - associated protein 70 (SWAP - 70) bundles actin filaments and contributes to the regulation of F - actin dynamics.
Platelet - activating factor - induced clathrin - mediated endocytosis requires β - arrestin - 1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.
By use of purified proteins, a small number of components are sufficient for the assembly of filopodia - like bundles: WASP - coated beads, actin, Arp2 / 3 complex, and fascin.
Beads coated with Arp2 / 3 - activating proteins can induce two distinct types of actin organization in cytoplasmic extracts: (1) comet tails or clouds displaying a dendritic array of actin filaments and (2) stars with filament bundles radiating from the bead.
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
RNA interference of fascin reduced the number of filopodia, and remaining filopodia had abnormal morphology with wavy and loosely bundled actin organization.
On the basis of analysis of this system, we proposed a model for filopodial formation in which actin filaments of a preexisting dendritic network are elongated by inhibition of capping and subsequently cross-linked into bundles by fascin.
While absent from normal epithelia, an actin bundling protein, fascin, becomes expressed in invasive carcinoma of different origins.