Live cell imaging
of actin dynamics in the filamentous fungus aspergillus nidulans.
STED nanoscopy
of actin dynamics in synapses deep inside living brain slices.
Not exact matches
Autophagosomes arise from the endoplasmic reticulum (ER)-- a network
of tubular membranes — and
actin dynamics is key in their formation and movement.
The link between endocytosis and generation
of cortical
actin waves may provide deeper insight into how cells maintain the composition and
dynamics of the plasma membrane.
This study reports for the first time the occurrence
of collective
dynamics of endocytosis and shows how this regulates the onset
of cortical
actin waves.
«These findings demonstrate that efficient
actin filament disassembly by GMF is essential for rapid
dynamics of cell protrusions, and that this
dynamics are important for cell migration in a three - dimensional tissue environment,» says Minna Poukkula from the research group
of professor Pekka Lappalainen.
«Our findings are consistent with the idea that an imbalance
of protein synthesis and
actin dynamics contribute to physiological problems in FXS mice,» explains New York University Professor Eric Klann, director NYU's Center for Neural Science and the study's senior author.
Notably, it also disrupts the activity
of a specific protein, CYFIP1, which regulates eIF4E as well as
actin dynamics and the structure
of dendrites — components
of a neuron where inputs from other neurons are located.
The rapid onset
of the freezing phenotype led to the hypothesis that Mcf1 may be acting on a pre-existing eukaryotic molecular switch governing
actin cytoskeletal
dynamics such as the rho GTPases.
WAFL, a new protein involved in regulation
of early endocytic transport at the intersection
of actin and microtubule
dynamics.
We further aim at deciphering the F -
actin cytsokeletal
dynamics of hematopoietic cells, important for migration, adhesion, homing.
In vivo
dynamics of clathrin and its adaptor - dependent recruitment to the
actin - based endocytic machinery in yeast.
Interference with
actin dynamics is superior to disturbance
of microtubule function in the inhibition
of human ovarian cancer cell motility.
Meanwhile, another group
of French researchers identified the same protein, ARHGAP10, as a partner with two other molecules — Arf1 and Arf6 — involved in both
actin dynamics deep within the cell and the turnover
of adherens junctions.
The switch - associated protein 70 (SWAP - 70) bundles
actin filaments and contributes to the regulation
of F -
actin dynamics.
Analysis
of F -
actin cytoskeletal
dynamics, integrin activity, cell migration and other cell biology parameters
Actin dynamics and organisation are tightly regulated processes responsible for the range
of different and specific cellular functions in response to various stimuli.
It is therefore essential to understand how changes in synaptic transmission can regulate the organization and
dynamics of actin binding proteins (ABPs).
Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator
of actin cytoskeleton
dynamics (i.e. the inner structural support
of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel growth), inflammation, and fibrosis (thickening and scarring
of tissue) associated with choroidal neovascularization (CNV) in wet AMD.
In this review, we will provide a detailed description
of the organization and
dynamics of F -
actin and ABPs in dendritic spines and will discuss the current models explaining how the
actin cytoskeleton sustains both structural and functional synaptic plasticity.