Sentences with phrase «of action potentials when»

The UAB researchers, led by corresponding author John Hablitz, Ph.D., professor and interim chair of Neurobiology, UAB School of Medicine, found that treatments that inhibit DNA methylation in cultured rat neocortical neurons caused an increase in the IME of those neurons, as shown by an increased frequency of a series of action potentials when the neurons were stimulated.

Not exact matches

Concerns about the safety of DOT - 111 tank cars date back to the mid-1990s, when the Transportation Safety Board recommended Transport Canada «take immediate action to further reduce the potential for the accidental release of the most toxic and volatile dangerous goods transported in Class 111A tank cars.»

«Because Mylan's Board has determined that risk oversight is the responsibility of the full board, all incumbent directors should be considered accountable for material failures of risk oversight over a number of years, when warning signs were available to the company but no actions appear to have been taken to mitigate or head off the significant potential risks that have since materialized.

As Credit Karma users explore the site, they receive suggestions for next steps, are able to simulate the impact of a potential action on their credit score or track when a public record will come off their report.

In contrast, when the market is free from the hostile syndrome we observe here, it's often possible to get some amount of «warning» about potential trouble from gradual deterioration of market action and a tendency for various «divergences» to develop as risk aversion increases.

Imitation may be the best form of flattery, but Canadians have good reason to be wary about US attention, especially when it comes to potential trade actions or industry support.

When you have organisms with eyes, they have more extended fields of potential action.

When a new brand is launched, it takes the ideas and focus of the suppliers and puts them into action to maximize growth potential.

Of course it would be silly to suggest that winning any game, cup or otherwise, isn't good for the club, but let's remember just how problematic FA Cup success has been for this club... I'm certainly not going to suggest I didn't enjoy seeing Arsenal win, I'm a fan of this club first and foremost, but how bad are things when you find yourself secretly wishing that your own team lost so that just maybe real change would finally come... I resent this team for even making me feel such thoughts and it's going to take a lot of effort on their part to earn my trust again... this club has treated the fans so poorly that it has created an incredibly fragile and toxic environment, so much so that a «what have you done for me lately» mentality has emerged... fans rise and fall depending on the results of each game because we don't have faith in those in charge to make the necessary changes to personnel and tactics... each time we win many fans attack any dissenting voices and make unrealistic claims about the players, the manager and the potential for unprecedented success... every time we lose the boo - birds run rampant, calling for heads to roll and predicting the worst... regardless of what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiOf course it would be silly to suggest that winning any game, cup or otherwise, isn't good for the club, but let's remember just how problematic FA Cup success has been for this club... I'm certainly not going to suggest I didn't enjoy seeing Arsenal win, I'm a fan of this club first and foremost, but how bad are things when you find yourself secretly wishing that your own team lost so that just maybe real change would finally come... I resent this team for even making me feel such thoughts and it's going to take a lot of effort on their part to earn my trust again... this club has treated the fans so poorly that it has created an incredibly fragile and toxic environment, so much so that a «what have you done for me lately» mentality has emerged... fans rise and fall depending on the results of each game because we don't have faith in those in charge to make the necessary changes to personnel and tactics... each time we win many fans attack any dissenting voices and make unrealistic claims about the players, the manager and the potential for unprecedented success... every time we lose the boo - birds run rampant, calling for heads to roll and predicting the worst... regardless of what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof this club first and foremost, but how bad are things when you find yourself secretly wishing that your own team lost so that just maybe real change would finally come... I resent this team for even making me feel such thoughts and it's going to take a lot of effort on their part to earn my trust again... this club has treated the fans so poorly that it has created an incredibly fragile and toxic environment, so much so that a «what have you done for me lately» mentality has emerged... fans rise and fall depending on the results of each game because we don't have faith in those in charge to make the necessary changes to personnel and tactics... each time we win many fans attack any dissenting voices and make unrealistic claims about the players, the manager and the potential for unprecedented success... every time we lose the boo - birds run rampant, calling for heads to roll and predicting the worst... regardless of what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof effort on their part to earn my trust again... this club has treated the fans so poorly that it has created an incredibly fragile and toxic environment, so much so that a «what have you done for me lately» mentality has emerged... fans rise and fall depending on the results of each game because we don't have faith in those in charge to make the necessary changes to personnel and tactics... each time we win many fans attack any dissenting voices and make unrealistic claims about the players, the manager and the potential for unprecedented success... every time we lose the boo - birds run rampant, calling for heads to roll and predicting the worst... regardless of what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof each game because we don't have faith in those in charge to make the necessary changes to personnel and tactics... each time we win many fans attack any dissenting voices and make unrealistic claims about the players, the manager and the potential for unprecedented success... every time we lose the boo - birds run rampant, calling for heads to roll and predicting the worst... regardless of what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof what side you fall on, it's not your fault, both sides are simply overcompensating for the horrible state of affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof affairs that have been percolating for several years... it's hard to take the long view when those in charge have lied incessantly and refuse to take any responsibilities for their own actions... in the end, we are trapped by the same catch - 22 that ManU faced upon Fergie's exit... less fearful of maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof maintaining the status quo than facing the unknown, which was validated, wrongly or rightly, by witnessing the difficulties they have faced during this transitory period... to be honest, the thing that scares me most is that this team has never prepared whatsoever for this eventuality, which considering our frugal nature and the way we have shunned many of our most revered former players is more than a little disconcertiof our most revered former players is more than a little disconcerting

First, campaign sites should always have some sort of action available for volunteers to take, so that you don't miss out on a chance to catch potential activists when they stop by.

It's unclear when legislation, or a detailed roster of potential actions, will emerge.

Cuomo, putting the best face on the potential lack of action, says he and the legislature already accomplished a lot earlier in the year, when they passed the state budget.

Although the draft decision expresses «its utmost concern» regarding the impacts of climate change on the World Heritage reefs, any action is delayed by a call «to further study the current and potential impacts of climate change» for possible action when the committee meets in 2018.

When the presynaptic neuron registers an influx of calcium ions, carrying the electrical surge of the action potential, vesicles that store neurotransmitters fuse to the cell's membrane and spill their contents outside the cell, where they bind to receptors on the postsynaptic neuron.

The team then monitored the cells» action potential patterns — the «bursts» of electrical energy that cells emit when communicating — and observed how the cells interacted over time.

By comparing hippocampal and cortical neurons in mono - culture (with other cells of the same type) and in co-culture (both cell types deposited within one device), the research showed that some features from hippocampal cells, like the percentage of action potential spikes found in bursts, were significantly higher when cultured together with cortical cells.

Action potential When about 0.1 volt kicks in (1/100, 000 the strength of a static shock from a rug), negatively charged potassium rushes out of the cell, and positively charged sodium floods in at 100,000,000 ions per second.

Muscle contraction is initiated when action potentials fired at the end - plate of the muscle cells propagate throughout the plasma membrane and trigger a conformational change of the voltage-gated CAV1.1 Ca2 + + channel (also called dihydropyridine receptor, DHPR).

Neuroscientists knew from physiology experiments on whole neurons that thousands of molecules of neurotransmitter are released from nerve endings when a nerve impulse, or «action potential,» arrives.

When activating your emerging potential, it's sometimes about taking lots of little actions — but just as often it's about taking a few big ones.

Ever since her surgery two years ago, she'd been seriously considering the second preventative procedure, but she was pushed into action when medical tests revealed potential signs of ovarian cancer.

The study of electricity in muscles probably began as early as the middle of the 1600s, with the discovery of the electric ray fish and experiments using frog legs (Clarys, 1994; Reaz et al. 2006), although it was not until 1792 that it was discovered that electricity could actually produce muscle contractions (Reaz et al. 2006), and 1849, when it was found that electric potential difference (also known as voltage) could be monitored in voluntary muscle actions (Reaz et al. 2006).

When recording EMG amplitude (in mV or μV), the voltage across the electrodes is constantly changing as a result of the stream of action potentials sent down the motor neurons.

Putting Your Choices Into Action Once you choose your Top 10 Must Haves and Can't Stands, now it's time to put them into action — share them with your matches during the Guided Communication process and reflect on them when you're sitting across the table from your potential partner on the first couple of Action Once you choose your Top 10 Must Haves and Can't Stands, now it's time to put them into action — share them with your matches during the Guided Communication process and reflect on them when you're sitting across the table from your potential partner on the first couple of action — share them with your matches during the Guided Communication process and reflect on them when you're sitting across the table from your potential partner on the first couple of dates.

Black, who marveled that the scripts bought for the most money were the ones that looked the least like those scripts when the movies finally came out, later described the film as «a frustrating proposition, so much potential, then a lot of «big action» which evolved over time and bloated a much less grandiose blueprint.

Perhaps learning from the excesses of Happy Feet, the creative minds behind this film make every effort to keep the action and tone light and frothy, even when dealing with such serious issues as bee cruelty and the potential end of human civilization without the important floral pollination process that bees provide.

I guess the ghosts also like messing around with the electronics, as one of the more action - heavy moments involves James springing out of bed when his alarm fails to wake him in time for a meeting with potential buyers.

In nearly half of cases (45 per cent, even when abuse is reported, no follow - up action is taken in, with one in three teachers (38 per cent) feeling it is necessary to stop using personal social media accounts over potential privacy and abuse concerns.

One of the very first actions a school should take when thinking about converting is to weigh up the potential benefits and hurdles.

Whilst considering when something is reasonably foreseeable, you should be allowing for the potential consequences; what action can be taken, regardless of cost, as this is covered under «so far as is reasonably practicable», which is explained below.

Topics to be discussed include: Court Procedure: An understanding of the civil litigation process in New Jersey as it pertains to negligence claims; Damages: Understanding the standards for, and the differences between Compensatory and Punitive Damages; Facility Maintenance: Identifying potential safety hazards related to facilities and grounds, and taking reasonable steps to address common problems; Indemnification: Identifying when the school district is responsible for the actions of its employees, and when it may disclaim coverage; Insurance Coverage Issues: Understanding what is, and is not covered under a school district's insurance policy, and understanding whether your district will be allowed to choose its attorney or be required to utilize the attorney assigned by the Insurance Company; Negligent Supervision: Examples of school district negligence liability lie within the school, on the athletic field, in the locker room, and on school trips; Sovereign Immunity: Understanding the effect of the New Jersey Torts Claims Act on negligence claims against school districts.

However, the Associations are reminded that, when reviewing carrier compliance with these provisions, as in all compliance matters, the Enforcement Office has considerable discretion and will consider the facts of each potential enforcement matter on a case - by - case basis before taking any action.

When a potential crunch is detected it reduces engine output and applies the brakes if the driver does not take any action to avoid the incident (a higher - speed system is available as part of the GT's Tech package).

(39 kg) raise the child into the adult belted zone • Anti-lock brakes (ABS) modulate the brakes for the driver to provide steering control while braking • Electronic Stability Program (ESP) applies selective braking or throttle reduction to control oversteer and understeer • Brake Assist ensures maximum braking action during panic stops • Traction Control reduces the throttle and / or applies selective braking to optimize traction during acceleration • Electronic Roll Mitigation determines when the vehicle is in a potential roll over condition and applies appropriate braking force to reduce the likelihood that such an event will occur • Rollover Sensing deploys seat - mounted side air bags, side - curtain air bags and seat - belt pretensioners • Trailer Sway Control helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a side impact

It continually scans traffic conditions ahead of the RDX, alerts the driver when it determines there is potential for a collision, and then applies automatic emergency braking to help reduce the severity of a collision if drivers don't take corrective action on their own.

Von Drehle devotes much space to the crucial conflict between Lincoln and General George McClellan, who consistently found reasons, or excuses, to keep his troops out of action when potential Union victories would help win the war and raise morale.

You'll learn how to run your part of the prelaunch campaign in your own prelaunch marketing playbook which covers a variety of topics including how to develop a street team and get them to take action to drive potential readers into stores, how to distribute ARCs to generate reviews, and how to spur prelaunch sales on Amazon to maximize your sales when your title releases.

The lower two charts display the weekly & monthly time - frame, with their respective closest swing high and swing lows clearly marked, as potential future Support / Resistance levels, where I will focus my attention to the price action that occurs on my top two charts (4 hour and daily time - frame) when price moves to one of my SR levels on the highest time - frames.

Skin in the Game is about the dynamics of the behaviors of people when their actions have downside risk along with the potential reward.

The reality is (which I know you agree with), when someone is looking for a debt relief solution, the best course of action is to educate themselves on all the potential courses of action, and then made an informed decision as to what the right choice is for them.

Helpfully the back of events provide an indicator of what that card is going to do, giving players a chance to mitigate the damage by removing potential problems when attempting to push their action cards through.

Many of these items, when used in battle, require the execution of some kind of action - command or mini-game to realize their full damage potential.

When we set out to bring Mirror's Edge to a new generation of gamers, we knew we wanted to deliver on the potential of the first game — building an iconic heroine in Faith, bringing a beautiful, stylized world to life, and delivering fluid first person action... In Mirror's Edge Catalyst, you will get to feel what it's like to glide across the skyline of the city.

Thinking of the potential of this foundation — the haven it offers for reflection and for action — reminds me of what happened one night when the power of art transformed one boy just 16 years old.

Sometimes, the near term damage reduction potential from climate action is heavily oversold, when it should be clear that this is a long term issue with virtually all the pay - off of any action today and over the next two decades to be found later this century.

But we will fulfill the potential of our democracy when all those individual obeservations can be synthesized into national action.

Rudolph also said a potential climate lawsuit represented a heavy - handed approach, adding, «Trying to get to the goal and figure out why you would want to go there» is important when considering any potential action as a government entity, including consideration of a lawsuit.

And when it comes to a potential dismissal of an action, it is crucial that notice is actually received.

The Reno Gazette - Journal today provides extensive coverage: «Police link judge shooting with homicide; suspect still missing ``; «Violence a key topic when judges gather ``; «Judge wants bulletproof windows; officials study tinted films, cite cost ``; «Weller handled hundreds of cases involving divorce ``; «Wedding party mistakes «pop» for champagne cork ``; «Potential violence surrounds family court cases, lawyers say ``; «Downtown restaurant in middle of action ``; and «Police continue search for shooting suspect.»

The «law of multiples» which can take many forms such as multiple lawyers doing the same type of work (or based on the same guidance) that leads to class action potential when there's an allegation that they all did it wrong; or the same lawyer is sued over doing the same (alleged wrong) thing multiple times; or a lawyer undertakes many mortgage transactions without considering that there are red flags that need to be brought to the attention of the lender — such as a significant increase in the value of the property in a very short period of time or inexplicable credits.