Sentences with phrase «of active gene expression»

Protein duo thwarts chromosomal scrambling and DNA breakage (2/11/2014) A new study by Dr. Mark Bedford establishes a link between the TDRD3 protein and an enzyme that unwinds DNA at regions of active gene expression.

The study establishes a link between TDRD3 and an enzyme that unwinds DNA at regions of active gene expression, and provides evidence that this partnership can prevent DNA breakage and chromosomal translocations - two of the hallmarks of cancer.

Not exact matches

«HPV - active tumors have high expression of immunoregulatory genes and therefore may respond to immune checkpoint inhibitor therapy.

For example, HPV - inactive tumors were 17 times more likely to contain disrupting TP53 gene mutations than HPV - active cervical cancers, rendering unnecessary the expression of the HPV E6 oncogene.

Visel and his colleagues studied gene expression in a developing mouse embryo, and found 120 enhancers active in cells of the face.

«One of the ways SUMO does this is by promoting the binding of Tup1 to active genes, which then acts to reduce their expression to appropriate levels,» explains Rosonina, in the Faculty of Science at York U.

«As a result of the previous study, we reported that SUMO is probably important for controlling expression of active genes because we found it on every gene we looked at, but only when they were turned on,» notes Rosonina.

Active NtrC binds to DNA and boosts the expression of certain genes that allow the cell to live without nitrogen.

When SETDB1 is active, the expression levels of target genes are repressed.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

Changes in DNA methylation in brain cells has been an extremely active research area since these epigenetic changes were shown to alter the expression of genes needed to form and maintain long - term memories.

By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in many advanced cancers, the let - 7 family of «microRNAs» — tiny snippets of RNA that can put the brakes on expression of selected genes — appears to prevent human cancer cells from reasserting their prenatal capacity to divide rapidly, travel and spread.

«The authors went on to study the resulting blastocysts for aneuploidy (frequency of abnormal chromosomes), and pattern of gene expression (which genes are active and at what level).

The dogma of DNA methylation is that it generally represses gene expression — in other words, methylated regions are transcriptionally silent, and unmethylated regions are often transcriptionally active.

These results suggest that Smed - beta - catenin - 1 may be active in the tail region and inhibited in the head region by the regulated expression of these Wnt genes.

The researchers thus went on to study the expression of Wnt genes during regeneration, and found that different members of the gene family were active at different locations across the planarian's head - to - tail axis.

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Using comparative genomics analysis, characterization of conserved domains and active sites, and expression analysis, 42 key genes involved in FA biosynthesis in oil palm were identified.

It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC - active genes.

Vitamin A, which is essential for your immune system just like vitamin D, is also a precursor to active hormones that regulate the expression of your genes, and they work in tandem.